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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620505
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crh
Name: corticotropin releasing hormone
Acc ID: CHEBI:38721
Term: methamidophos
Definition: An organic thiophosphate resulting from the N-deacylation of the proinsecticide acephate.
Chemical ID: MESH:C014655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhincreases expressionEXP 6480464CTDmethamidophos results in increased expression of CRH mRNAPMID:12039681
Crhincreases secretionEXP 6480464CTDmethamidophos results in increased secretion of CRH proteinPMID:12039681
Crhmultiple interactionsEXP 6480464CTDAtropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]; methamidophos promotes the reaction [FOS protein binds to CRH promoter]; Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein]PMID:12039681
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