RGD Reference Report - Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. - Rat Genome Database

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Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats.

Authors: Samarghandian, S  Ohata, H  Yamauchi, N  Shibasaki, T 
Citation: Samarghandian S, etal., Neuroscience 2003;116(2):519-24.
RGD ID: 704396
Pubmed: PMID:12559107   (View Abstract at PubMed)

Several kinds of stress such as psychological stress, restraint, and foot shock inhibit feeding behavior through corticotropin-releasing factor (CRF). In contrast, a mild tail pinch increases food intake in rats. Although dopamine and opioid are thought to be involved in tail-pinch-induced food intake, it is unknown whether CRF participates in this phenomenon. Therefore, we attempted to clarify this issue using rats. A 30-s tail pinch increased food intake in 30 min after the tail pinch, and this increase was blocked by intraperitoneal injection of CRF receptor type 1 selective antagonist. CRF increased food intake in 30 min after intracerebroventricular injection at a dose of 2 or 10 ng, and this increase was also blocked by CRF receptor type 1 antagonist. Tail-pinch- or CRF-induced food intake was blocked by naloxone, pimozide, and spiperone. These results suggest that CRF, through CRF receptor type 1 as well as opioid and dopaminergic systems, are involved in the mechanism of tail-pinch-induced food intake. The results also suggest that brain CRF has dual effects on food intake, hyperphagia and anorexia, in a stress-dependent manner.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
feeding behavior  IMP 704396 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crhr1  (corticotropin releasing hormone receptor 1)

Objects referenced in this article
Gene CRH corticotropin releasing hormone Homo sapiens
Gene Crh corticotropin releasing hormone Rattus norvegicus

Additional Information