Bche (butyrylcholinesterase) - Rat Genome Database

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Gene: Bche (butyrylcholinesterase) Rattus norvegicus
Analyze
Symbol: Bche
Name: butyrylcholinesterase
RGD ID: 619996
Description: Enables choline binding activity and cholinesterase activity. Involved in several processes, including negative regulation of synaptic transmission; neuroblast differentiation; and response to folic acid. Located in endoplasmic reticulum lumen and extracellular space. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); epilepsy; and inherited metabolic disorder (multiple). Orthologous to human BCHE (butyrylcholinesterase); PARTICIPATES IN heroin pharmacodynamics pathway; heroin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cholinesterase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82160,607,289 - 160,699,760 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2160,606,288 - 160,699,760 (-)EnsemblGRCr8
mRatBN7.22158,308,674 - 158,401,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2158,307,584 - 158,401,148 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2165,439,220 - 165,525,241 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02163,487,797 - 163,573,811 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02158,120,569 - 158,206,587 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02171,104,476 - 171,196,186 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2171,100,140 - 171,196,395 (-)Ensemblrn6Rnor6.0
Rnor_5.02190,443,044 - 190,536,106 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42164,329,613 - 164,427,994 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2152,547,587 - 152,638,478 (-)NCBICelera
RGSC_v3.12164,279,575 - 164,377,957 (-)NCBI
Cytogenetic Map2q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acholinesterasemia  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (IMP)
Amyloid Plaques  (ISO)
Apnea  (ISO)
autism spectrum disorder  (ISO)
bacterial meningitis  (ISO)
Bamforth-Lazarus syndrome  (ISO)
Breast Neoplasms  (ISO)
Butyrylcholinesterase Deficiency  (ISO)
Butyrylcholinesterase Deficiency, Fluoride-Resistant, Japanese Type  (ISO)
cannabis abuse  (ISO)
Cardiotoxicity  (ISO)
cocaine abuse  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Death  (ISO)
dementia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dystonia  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Diabetes Mellitus  (IDA)
familial hyperlipidemia  (ISO)
Fasciculation  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (IDA)
Hyperkinesis  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (ISO)
leptospirosis  (IEP)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
muscular dystrophy  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Organophosphate Poisoning  (ISO)
Paralysis  (ISO)
Paresis  (ISO)
Poisoning  (ISO)
Postoperative Complications  (ISO)
primary progressive multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
secondary Parkinson disease  (ISO)
sleep apnea  (ISO)
stroke  (ISO)
Tachycardia  (ISO)
toxic encephalopathy  (ISO)
Trismus  (ISO)
trypanosomiasis  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(2-chloroethyl)phosphonic acid  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (ISO)
1,2,3-Trichloropropane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,5-diethylbarbituric acid  (ISO)
6-acetylmorphine  (ISO)
acephate  (EXP)
acetamide  (EXP)
acetamiprid  (EXP)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-linolenic acid  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asoxime chloride  (ISO)
atropine  (EXP,ISO)
Avizafone  (ISO)
Bacoside a  (ISO)
bambuterol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
Benzoylcholine  (ISO)
Betanin  (EXP)
bicalutamide  (ISO)
bifenthrin  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butyrylcholine  (ISO)
butyrylthiocholine  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbaryl  (EXP)
carbofuran  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorphenamine  (ISO)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (EXP)
choline  (ISO)
chrysene  (ISO)
chrysin  (ISO)
cinchocaine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumaphos oxon  (EXP)
Cryptotanshinone  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (EXP)
D-glucose  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
decamethonium  (ISO)
demeton-S-methyl  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diacetylmonoxime  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
diazoxon  (EXP,ISO)
dichlorvos  (EXP,ISO)
diethylstilbestrol  (EXP)
diisopropyl fluorophosphate  (EXP,ISO)
dimenhydrinate  (ISO)
dimethoate  (EXP,ISO)
diphenhydramine  (ISO)
Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)-  (EXP,ISO)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ecgonine methyl ester  (ISO)
ecothiopate iodide  (ISO)
edrophonium  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
ferulic acid  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formetanate  (EXP)
fucoxanthin  (ISO)
furan  (EXP)
galanthamine  (EXP,ISO)
galanthamine Trifluoroacetic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heroin  (ISO)
HLo7  (ISO)
homocysteine  (EXP)
ifosfamide  (EXP)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-butyric acid  (EXP)
indometacin  (ISO)
isoflurane  (ISO)
Isosorbide  (ISO)
Kokusaginine  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lycopene  (EXP)
magnesium sulfate  (EXP)
malachite green cation  (ISO)
malaoxon  (ISO)
malathion  (EXP,ISO)
melphalan  (ISO)
mepyramine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamidophos  (ISO)
methiocarb  (EXP)
methomyl  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
Mipafox  (ISO)
Mivacurium  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP)
morin  (EXP)
morphine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naftalofos  (EXP)
naringin  (EXP)
neostigmine  (ISO)
nickel atom  (ISO)
o-cresol  (ISO)
okadaic acid  (ISO)
omethoate  (ISO)
organophosphorus compound  (ISO)
oxamyl  (EXP)
oxydemeton-methyl  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (EXP,ISO)
paraquat  (EXP,ISO)
pararosaniline free base  (ISO)
parathion  (EXP,ISO)
parathion-methyl  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenothiazines  (ISO)
phenyl acetate  (ISO)
phenylmercury acetate  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
phloretin  (ISO)
phorate  (EXP)
phosphoryl trichloride  (ISO)
phoxim  (EXP)
physostigmine  (EXP,ISO)
pioglitazone  (ISO)
piperidine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pralidoxime  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
profenamine  (ISO)
profenofos  (ISO)
promazine  (ISO)
promethazine  (EXP,ISO)
propidium  (ISO)
Propionylcholine  (ISO)
propoxur  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (EXP)
quinalphos  (ISO)
ranitidine  (ISO)
remdesivir  (ISO)
resveratrol  (ISO)
rivastigmine  (EXP,ISO)
rotenone  (EXP,ISO)
salicyl alcohol  (ISO)
sarin  (EXP,ISO)
SB 431542  (ISO)
silicon atom  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
solanidine  (ISO)
solasodine  (ISO)
Soman  (EXP,ISO)
streptozocin  (ISO)
succinylcholine  (ISO)
Succinylmonocholine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrine  (ISO)
tapentadol  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraethylammonium  (ISO)
tetramethylammonium  (ISO)
thiazolidines  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
Tiapamil  (ISO)
tomatidine  (ISO)
tramadol  (EXP)
trichlorfon  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimedoxime bromide  (ISO)
Tripelennamine  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
tyloxapol  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
VX nerve agent  (EXP,ISO)
zinc oxide  (ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus. Abbott CA, etal., Clin Sci (Lond). 1993 Jul;85(1):77-81.
2. Butyrylcholinesterase activity and risk factors for coronary artery disease. Alcântara VM, etal., Scand J Clin Lab Invest. 2002;62(5):399-404.
3. Detection of sarin in plasma of rats after inhalation intoxication. Bartosova L, etal., J Enzyme Inhib Med Chem. 2006 Oct;21(5):509-14.
4. Cholinesterase activities in cerebrospinal fluid of patients with idiopathic convulsive disorders. Basu PS, etal., Clin Chim Acta. 1995 Feb 28;235(1):107-12.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Ben Assayag E, etal., Mol Med. 2010 Jul-Aug;16(7-8):278-86. doi: 10.2119/molmed.2010.00015. Epub 2010 Apr 14.
7. Cholinesterase modulations in patients with acute bacterial meningitis. Berg RM, etal., Scand J Clin Lab Invest. 2011 Jul;71(4):350-2. doi: 10.3109/00365513.2011.558107. Epub 2011 Feb 8.
8. Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats. Bradamante V, etal., Arzneimittelforschung. 2006;56(2):64-9.
9. Cholinesterases as markers of the inflammatory process in rats infected with Leptospira interrogans serovar Icterohaemorrhagiae. da Silva CB, etal., J Med Microbiol. 2012 Feb;61(Pt 2):278-84. doi: 10.1099/jmm.0.035501-0. Epub 2011 Sep 15.
10. Apolipoprotein e4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease. Darreh-Shori T, etal., J Alzheimers Dis. 2012;28(2):443-58. doi: 10.3233/JAD-2011-111088.
11. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Darreh-Shori T, etal., Neurobiol Dis. 2006 Nov;24(2):326-33. Epub 2006 Sep 14.
12. Butyrylcholinesterase activity in multiple sclerosis neuropathology. Darvesh S, etal., Chem Biol Interact. 2010 Sep 6;187(1-3):425-31. doi: 10.1016/j.cbi.2010.01.037. Epub 2010 Feb 1.
13. Butyrylcholinesterase is associated with ß-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. Darvesh S, etal., J Neuropathol Exp Neurol. 2012 Jan;71(1):2-14. doi: 10.1097/NEN.0b013e31823cc7a6.
14. Effect of alloxan-induced diabetes on serum and cardiac butyrylcholinesterases in the rat. Dave KR and Katyare SS, J Endocrinol. 2002 Oct;175(1):241-50.
15. Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans. Duysen EG and Lockridge O, Drug Metab Dispos. 2011 Aug;39(8):1321-3. doi: 10.1124/dmd.111.039917. Epub 2011 May 3.
16. Cholinesterase activity in the hypoglossal nucleus of the rat and the changes produced by axotomy: a light and electron microscopic study. Flumerfelt BA and Lewis PR, J Anat. 1975 Apr;119(Pt 2):309-31.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Enzymes of the cholinergic system in islets of Langerhans. Godfrey DA and Matschinsky FM, J Histochem Cytochem. 1975 Sep;23(9):645-51.
20. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Greig NH, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17213-8. Epub 2005 Nov 7.
21. Increased blood plasma hydrolysis of acetylsalicylic acid in type 2 diabetic patients: a role of plasma esterases. Gresner P, etal., Biochim Biophys Acta. 2006 Feb;1760(2):207-15. Epub 2005 Dec 21.
22. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. Hashim Y, etal., Diabetologia. 2001 Dec;44(12):2227-30.
23. Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine. Hrabovska A, etal., FEBS J. 2006 Mar;273(6):1185-97.
24. Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance. Iwasaki T, etal., Intern Med. 2007;46(19):1633-9. Epub 2007 Oct 1.
25. Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients. Kálmán J, etal., Life Sci. 2004 Jul 23;75(10):1195-204.
26. Variant K of butyrylcholinesterase and risk of early-onset type 1 diabetes mellitus in Euro-Brazilians. Lepienski LM, etal., Diabetes Obes Metab. 2006 Nov;8(6):709-11.
27. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. Li B, etal., J Neurochem 2000 Sep;75(3):1320-31.
28. Butyrylcholinesterase activity and plasma lipids in dexamethasone treated rats. Lucic Vrdoljak A, etal., Acta Pharm. 2005 Jun;55(2):177-85.
29. [Butyrylcholinesterase activity in schizophrenic patients]. Mabrouk H, etal., Ann Biol Clin (Paris). 2011 Nov-Dec;69(6):647-52. doi: 10.1684/abc.2011.0634.
30. Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia. Matté C, etal., Int J Dev Neurosci. 2006 Feb;24(1):3-8. Epub 2006 Jan 25.
31. Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. McGuire MC, etal., Proc Natl Acad Sci U S A. 1989 Feb;86(3):953-7.
32. Muscular dystrophy with laminin deficiency decreases the content of butyrylcholinesterase tetramers in sciatic nerves of Lama2dy mice. Moral-Naranjo MT, etal., Neurosci Lett. 2002 Oct 18;331(3):155-8.
33. Biochemical Analysis and Association of Butyrylcholinesterase SNPs rs3495 and rs1803274 with Substance Abuse Disorder. Munir S, etal., J Mol Neurosci. 2019 Mar;67(3):445-455. doi: 10.1007/s12031-018-1251-7. Epub 2019 Feb 1.
34. The role of cholinesterases in rat urinary bladder contractility. Nakahara T, etal., Urol Res 2003 Jul;31(3):223-6. Epub 2003 May 08.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Cholinergic status modulations in human volunteers under acute inflammation. Ofek K, etal., J Mol Med (Berl). 2007 Nov;85(11):1239-51. Epub 2007 Jul 27.
37. Genetic risk for restenosis after coronary stenting. Oguri M, etal., Atherosclerosis. 2007 Oct;194(2):e172-8. Epub 2007 Feb 1.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. Modulation of impaired cholinesterase activity in experimental diabetes: effect of Gymnema montanum leaf extract. Ramkumar KM, etal., J Basic Clin Physiol Pharmacol. 2005;16(1):17-35.
41. Relationship between serum butyrylcholinesterase and the metabolic syndrome. Randell EW, etal., Clin Biochem. 2005 Sep;38(9):799-805.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. Ruberg M, etal., J Neurol Neurosurg Psychiatry. 1987 May;50(5):538-43.
46. Identification of a point mutation associated with a silent phenotype of human serum butyrylcholinesterase--a case of familial cholinesterasemia. Sakamoto N, etal., Clin Chim Acta. 1998 Jun 22;274(2):159-66.
47. Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues. Svoboda Z, etal., Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:183-6.
48. Acetyl- and butyrylcholinesterase in normal and diabetic rat retina. Sánchez-Chávez G and Salceda R, Neurochem Res. 2001 Feb;26(2):153-9.
49. Butyrylcholinesterase K variants increase the risk of coronary artery disease in the population of western Iran. Vaisi-Raygani A, etal., Scand J Clin Lab Invest. 2008;68(2):123-9. Epub 2007 Nov 21.
50. Trypanosoma evansi: cholinesterase activity in acutely infected Wistar rats. Wolkmer P, etal., Exp Parasitol. 2010 Jul;125(3):251-5. doi: 10.1016/j.exppara.2010.01.024. Epub 2010 Feb 6.
51. Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction. Wyse AT, etal., Neurochem Res. 2004 Feb;29(2):385-9.
52. Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model. Yoo DY, etal., Neurochem Int. 2011 Oct;59(5):722-8. doi: 10.1016/j.neuint.2011.06.021. Epub 2011 Jul 13.
Additional References at PubMed
PMID:8651510   PMID:15938128   PMID:16270756   PMID:17212694   PMID:17660298   PMID:19452557   PMID:20399201   PMID:20599604   PMID:20883446   PMID:21059932   PMID:21094673   PMID:21571001  
PMID:22516433   PMID:22726956   PMID:22922167   PMID:22982053   PMID:24039284   PMID:34505519  


Genomics

Comparative Map Data
Bche
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82160,607,289 - 160,699,760 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2160,606,288 - 160,699,760 (-)EnsemblGRCr8
mRatBN7.22158,308,674 - 158,401,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2158,307,584 - 158,401,148 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2165,439,220 - 165,525,241 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02163,487,797 - 163,573,811 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02158,120,569 - 158,206,587 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02171,104,476 - 171,196,186 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2171,100,140 - 171,196,395 (-)Ensemblrn6Rnor6.0
Rnor_5.02190,443,044 - 190,536,106 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42164,329,613 - 164,427,994 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2152,547,587 - 152,638,478 (-)NCBICelera
RGSC_v3.12164,279,575 - 164,377,957 (-)NCBI
Cytogenetic Map2q32NCBI
BCHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383165,772,904 - 165,837,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3165,772,904 - 165,837,462 (-)Ensemblhg38GRCh38
GRCh373165,490,692 - 165,555,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363166,973,386 - 167,037,947 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343166,973,394 - 167,037,952NCBI
Celera3163,889,280 - 163,954,027 (-)NCBICelera
Cytogenetic Map3q26.1NCBI
HuRef3162,859,251 - 162,924,002 (-)NCBIHuRef
CHM1_13165,453,437 - 165,518,145 (-)NCBICHM1_1
T2T-CHM13v2.03168,555,830 - 168,620,600 (-)NCBIT2T-CHM13v2.0
Bche
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39373,543,138 - 73,615,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl373,543,141 - 73,615,748 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38373,635,805 - 73,708,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl373,635,808 - 73,708,415 (-)Ensemblmm10GRCm38
MGSCv37373,439,731 - 73,512,337 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36373,721,734 - 73,794,168 (-)NCBIMGSCv36mm8
Celera373,748,016 - 73,817,761 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map333.61NCBI
Bche
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544815,329,273 - 15,396,970 (-)Ensembl
ChiLan1.0NW_00495544815,327,374 - 15,396,827 (-)NCBIChiLan1.0ChiLan1.0
BCHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22163,667,263 - 163,731,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13163,670,621 - 163,736,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03162,794,184 - 162,858,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13170,845,494 - 170,910,662 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,845,494 - 170,911,481 (-)EnsemblpanPan2panpan1.1
BCHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13430,912,632 - 30,977,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3430,912,632 - 30,977,583 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3439,973,463 - 40,038,402 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03430,973,335 - 31,038,334 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3430,972,845 - 31,038,271 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13430,917,722 - 30,976,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03430,878,067 - 30,943,017 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03431,141,049 - 31,206,522 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bche
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560297,068,925 - 97,127,830 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367071,854,444 - 1,913,460 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367071,784,338 - 1,913,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113104,946,732 - 105,007,568 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213113,411,303 - 113,471,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCHE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11523,708,121 - 23,778,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1523,708,155 - 23,778,286 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606332,661,071 - 32,730,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bche
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473043,793,040 - 43,843,519 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473043,793,550 - 43,849,169 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bche
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1380,060,767 - 80,136,367 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bche
784 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000013279
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
AW531512  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22158,308,390 - 158,308,578 (+)MAPPERmRatBN7.2
Rnor_6.02171,104,193 - 171,104,380NCBIRnor6.0
Rnor_5.02190,442,761 - 190,442,948UniSTSRnor5.0
RGSC_v3.42164,329,330 - 164,329,517UniSTSRGSC3.4
Celera2152,547,304 - 152,547,491UniSTS
RH 3.4 Map21031.0UniSTS
Cytogenetic Map2q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 11 76 158 91 90 59 25 59 6 297 130 7 146 82 102 31 23 23

Sequence


Ensembl Acc Id: ENSRNOT00000013279   ⟹   ENSRNOP00000013279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2160,606,288 - 160,699,760 (-)Ensembl
mRatBN7.2 Ensembl2158,307,584 - 158,401,148 (-)Ensembl
Rnor_6.0 Ensembl2171,100,140 - 171,196,395 (-)Ensembl
RefSeq Acc Id: NM_022942   ⟹   NP_075231
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82160,607,289 - 160,699,760 (-)NCBI
mRatBN7.22158,308,674 - 158,401,148 (-)NCBI
Rnor_6.02171,104,476 - 171,196,186 (-)NCBI
Rnor_5.02190,443,044 - 190,536,106 (-)NCBI
RGSC_v3.42164,329,613 - 164,427,994 (-)RGD
Celera2152,547,587 - 152,638,478 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_075231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF44713 (Get FASTA)   NCBI Sequence Viewer  
  EDM00889 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013279
  ENSRNOP00000013279.3
RefSeq Acc Id: NP_075231   ⟸   NM_022942
- Peptide Label: precursor
- UniProtKB: Q9JKC1 (UniProtKB/TrEMBL),   F1LQK0 (UniProtKB/TrEMBL),   A0A8J8XQI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013279   ⟸   ENSRNOT00000013279
Protein Domains
Acetylcholinesterase tetramerisation   Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKC1-F1-model_v2 AlphaFold Q9JKC1 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691377
Promoter ID:EPDNEW_R1902
Type:multiple initiation site
Name:Bche_1
Description:butyrylcholinesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02171,196,236 - 171,196,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619996 AgrOrtholog
BioCyc Gene G2FUF-52786 BioCyc
Ensembl Genes ENSRNOG00000009826 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013279 ENTREZGENE
  ENSRNOT00000013279.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AChE-related_enzymes UniProtKB/TrEMBL
  AChE_tetra UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Cholinesterase UniProtKB/TrEMBL
KEGG Report rno:65036 UniProtKB/TrEMBL
NCBI Gene 65036 ENTREZGENE
PANTHER ACETYLCHOLINESTERASE UniProtKB/TrEMBL
  CHOLINESTERASE UniProtKB/TrEMBL
Pfam AChE_tetra UniProtKB/TrEMBL
  COesterase UniProtKB/TrEMBL
PharmGKB BCHE RGD
PhenoGen Bche PhenoGen
PRINTS CHOLNESTRASE UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009826 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8J8XQI9 ENTREZGENE, UniProtKB/TrEMBL
  F1LQK0 ENTREZGENE
  Q9JKC1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LQK0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bche  butyrylcholinesterase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bche  butyrylcholinesterase      Symbol and Name status set to provisional 70820 PROVISIONAL