RGD Reference Report - Butyrylcholinesterase activity in multiple sclerosis neuropathology. - Rat Genome Database

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Butyrylcholinesterase activity in multiple sclerosis neuropathology.

Authors: Darvesh, Sultan  Leblanc, Andrea M  Macdonald, Ian R  Reid, George A  Bhan, Virender  Macaulay, Robert J  Fisk, John D 
Citation: Darvesh S, etal., Chem Biol Interact. 2010 Sep 6;187(1-3):425-31. doi: 10.1016/j.cbi.2010.01.037. Epub 2010 Feb 1.
RGD ID: 5687690
Pubmed: PMID:20122907   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cbi.2010.01.037   (Journal Full-text)

Butyrylcholinesterase (BuChE) is an enzyme capable of hydrolysing a wide variety of esters including acetylcholine, a molecule involved in neurotransmission and modulation of immune cell activity. In the brain, BuChE is expressed in white matter and certain populations of neurons and glia. Multiple sclerosis (MS) is an autoimmune disease affecting white matter characterized by neuroinflammation and neurodegeneration in the central nervous system. Here we demonstrate alterations in BuChE activity in MS white matter lesions, including diminished enzyme activity associated with myelin and an increased activity in cells with microglial morphology. Increased BuChE activity within MS lesions could contribute to the pro-inflammatory immune responses through hydrolysis of acetylcholine and to demyelination through hydrolytic deacylation of myelin proteins such as proteolipid protein. This suggests that BuChE could be a potential target for novel disease-modifying strategies for MS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
primary progressive multiple sclerosis  IEP 5687690 RGD 
primary progressive multiple sclerosis  ISOBCHE (Homo sapiens)5687690; 5687690 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bche  (butyrylcholinesterase)

Genes (Mus musculus)
Bche  (butyrylcholinesterase)

Genes (Homo sapiens)
BCHE  (butyrylcholinesterase)


Additional Information