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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:27827
Term: paraoxon
Definition: An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.
Chemical ID: MESH:D010261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityEXP 6480464CTDParaoxon results in decreased activity of BCHE mRNA; Paraoxon results in decreased activity of BCHE proteinPMID:12629810 PMID:19272400 PMID:33497710 PMID:33592259 PMID:4631366
Bcheaffects bindingISOBCHE (Homo sapiens)6480464CTDParaoxon binds to BCHE protein; Paraoxon binds to BCHE protein modified formPMID:18514178
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDParaoxon results in decreased activity of BCHE proteinPMID:16213467 PMID:18617161 PMID:20206154 PMID:20227398 PMID:21673941 PMID:24912784 PMID:27693733 PMID:29614332 PMID:33592259 PMID:4631366
Bchedecreases activityISOBche (Mus musculus)6480464CTDParaoxon results in decreased activity of BCHE proteinPMID:22209767 PMID:23178380 PMID:27108687 PMID:4631366
Bchedecreases response to substanceISOBCHE (Homo sapiens)6480464CTDBCHE protein results in decreased susceptibility to ParaoxonPMID:31201777
Bchedecreases response to substanceISOBche (Mus musculus)6480464CTDBCHE protein results in decreased susceptibility to ParaoxonPMID:23178380
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTDALB protein results in decreased susceptibility to [Paraoxon results in decreased activity of BCHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Glucosides inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Paraoxon binds to and results in decreased activity of BCHE protein; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]PMID:12518340 PMID:15669026 PMID:16193528 PMID:18617161 PMID:20211614 PMID:20227398 PMID:23178380 PMID:27693733 PMID:29614332
Bchemultiple interactionsISOBche (Mus musculus)6480464CTDBCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]PMID:23178380
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