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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:34690
Term: dichlorvos
Definition: An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.
Chemical ID: MESH:D004006
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityEXP 6480464CTDDichlorvos results in decreased activity of BCHE proteinPMID:1276991 PMID:12828128 PMID:19504058 PMID:235931 PMID:4631366 PMID:7150809
Bchemultiple interactionsEXP 6480464CTDdiacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; Magnesium Sulfate promotes the reaction [Dichlorvos results in decreased activity of BCHE protein]PMID:1276991 PMID:19504058
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDDichlorvos results in decreased activity of BCHE proteinPMID:12190811 PMID:16036766 PMID:17698511 PMID:20395308 PMID:21673941 PMID:235931 PMID:33517499 PMID:423703 PMID:4631366
Bchedecreases activityISOBche (Mus musculus)6480464CTDDichlorvos results in decreased activity of BCHE proteinPMID:21767560 PMID:22209767 PMID:4631366
Bchedecreases expressionISOBche (Mus musculus)6480464CTDDichlorvos results in decreased expression of BCHE proteinPMID:27899289
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTD[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Dichlorvos binds to and results in decreased activity of BCHE protein; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]PMID:12190811 PMID:16036766 PMID:16193528 PMID:20229498 PMID:423703
Bchemultiple interactionsISOBche (Mus musculus)6480464CTD[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]; Dichlorvos binds to and results in decreased activity of BCHE proteinPMID:16598855 PMID:27899289
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