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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:9195
Term: Soman
Definition: A phosphonic ester that has formula C7H16FO2P.
Chemical ID: MESH:D012999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityEXP 6480464CTDSoman results in decreased activity of BCHE proteinPMID:20816720 PMID:27287416
Bcheaffects bindingISOBCHE (Homo sapiens)6480464CTDSoman binds to BCHE proteinPMID:19715348
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDSoman analog results in decreased activity of BCHE protein; Soman results in decreased activity of BCHE proteinPMID:17698511 PMID:19715346
Bchedecreases activityISOBche (Mus musculus)6480464CTDSoman analog results in decreased activity of BCHE proteinPMID:22209767
Bchedecreases response to substanceISOBCHE (Homo sapiens)6480464CTDBCHE protein results in decreased susceptibility to SomanPMID:23044488 PMID:31129133
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTDPON1 protein inhibits the reaction [Soman results in decreased activity of BCHE protein]; Soman analog promotes the reaction [Soman binds to BCHE protein]PMID:19715348 PMID:21329748
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