RGD Reference Report - Relationship between serum butyrylcholinesterase and the metabolic syndrome. - Rat Genome Database

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Relationship between serum butyrylcholinesterase and the metabolic syndrome.

Authors: Randell, Edward W  Mathews, Maria S  Zhang, Hongwei  Seraj, Jim S  Sun, Guang 
Citation: Randell EW, etal., Clin Biochem. 2005 Sep;38(9):799-805.
RGD ID: 1601317
Pubmed: PMID:15907830   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clinbiochem.2005.04.008   (Journal Full-text)


OBJECTIVE: To identify independent predictors of serum butyrylcholinesterase (BuChE) activity and examine its relationship with the metabolic syndrome.
DESIGN AND METHODS: Serum BuChE activity was measured and metabolic syndrome risk factors were assessed in 1097 healthy subjects recruited from the Newfoundland adult population.
RESULTS: Serum BuChE activity was related to insulin homeostasis and correlated with fasting insulin levels (r = 0.266, P < 0.001) and insulin resistance (HOMA-R) index (r = 0.292, P < 0.001) and was higher in individuals with risk factors for the metabolic syndrome. BuChE activity was higher in males than in females and correlated most strongly with serum triglyceride levels (r = 0.363, P < 0.001) and indicators of abdominal obesity (r = 0.355, P < 0.001). Percent trunk fat (beta = 0.185, P < 0.001), triglyceride levels (beta = 0.225, P < 0.001), sex (beta = -0.202, P = 0.001), glucose (beta = 0.209, P < 0.001), insulin (beta = 0.360, P = 0.011), HOMA-R (beta = -0.319, P = 0.044), and age (beta = 0.086, P = 0.002) were independent predictors of BuChE activity.
CONCLUSIONS: These results suggest the involvement of BuChE in the pathophysiological process constituting the metabolic syndrome. Whether increased BuChE activity precedes or follows the development of risk factors is not known.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Metabolic Syndrome  IEP 1601317protein:increased expression:serumRGD 
Metabolic Syndrome  ISOBCHE (Homo sapiens)1601317; 1601317protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bche  (butyrylcholinesterase)

Genes (Mus musculus)
Bche  (butyrylcholinesterase)

Genes (Homo sapiens)
BCHE  (butyrylcholinesterase)


Additional Information