Nr4a2 (nuclear receptor subfamily 4, group A, member 2) - Rat Genome Database

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Gene: Nr4a2 (nuclear receptor subfamily 4, group A, member 2) Rattus norvegicus
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Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
RGD ID: 3202
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; and retina development in camera-type eye. Acts upstream of or within response to insecticide. Located in chromatin. Biomarker of Parkinsonism and epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear orphan receptor HZF-3; nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor subfamily 4 group A member 2 variant TINUR; nur related protein 1; NUR-related factor 1; Nurr1; orphan nuclear receptor NURR1; orphan receptor; regenerating liver nuclear receptor 1; RNR-1; RNR1; SL-322
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,098,739 - 62,115,926 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl362,098,743 - 62,106,769 (-)EnsemblGRCr8
mRatBN7.2341,689,847 - 41,707,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx345,028,318 - 45,033,797 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,613,078 - 53,618,558 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,404,666 - 51,410,139 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,111,258 - 43,128,391 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)Ensemblrn6Rnor6.0
Rnor_5.0348,183,106 - 48,192,467 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4338,866,205 - 38,871,678 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera339,783,304 - 39,788,777 (-)NCBICelera
RGSC_v3.1338,763,218 - 38,769,911 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (EXP)
bis(2-butoxyethyl)phthalate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
Carnosol  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dabigatran  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geraniol  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (EXP)
glycidol  (EXP)
GSK-J4  (ISO)
GW 1929  (EXP)
heroin  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP)
lithium hydride  (ISO)
lucanthone  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
N(6)-butyryl-cAMP  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
PCB138  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phencyclidine  (ISO)
phenformin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picoxystrobin  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (ISO)
probenecid  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP,ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetradecane  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
torcetrapib  (ISO)
triacsin C  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
cellular response to corticotropin-releasing hormone stimulus  (IBA,ISO,ISS)
cellular response to oxidative stress  (ISO)
central nervous system neuron differentiation  (IBA,ISO)
central nervous system projection neuron axonogenesis  (ISO)
cerebral cortex development  (IEP)
DNA-templated transcription  (IEA,ISO,ISS)
dopamine biosynthetic process  (ISO)
dopamine metabolic process  (ISO)
dopaminergic neuron differentiation  (IBA,ISO,ISS)
fat cell differentiation  (ISO,ISS)
gene expression  (ISO)
general adaptation syndrome  (ISO)
habenula development  (ISO)
intracellular receptor signaling pathway  (IEA)
learning or memory  (IMP)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (IMP,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nervous system development  (ISO)
neuron differentiation  (ISO)
neuron maturation  (ISO)
neuron migration  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
post-embryonic development  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of dopamine metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of respiratory gaseous exchange  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to amphetamine  (ISO)
response to hypoxia  (ISO)
response to insecticide  (IDA)
retina development in camera-type eye  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival. Barneda-Zahonero B, etal., J Biol Chem. 2012 Mar 30;287(14):11351-62. doi: 10.1074/jbc.M111.272427. Epub 2012 Jan 31.
2. Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory. Colón-Cesario WI, etal., Learn Mem. 2006 Nov-Dec;13(6):734-44. doi: 10.1101/lm.407706.
3. Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity. Eells JB, etal., PLoS One. 2015 Apr 9;10(4):e0119280. doi: 10.1371/journal.pone.0119280. eCollection 2015.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Green AL, etal., Neuropharmacology. 2017 Oct;125:189-196. doi: 10.1016/j.neuropharm.2017.07.020. Epub 2017 Jul 22.
7. Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. Kandil EA, etal., Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1141-1150. doi: 10.1111/1440-1681.13162. Epub 2019 Sep 9.
8. Identification of a new brain-specific transcription factor, NURR1. Law SW, etal., Mol Endocrinol. 1992 Dec;6(12):2129-35.
9. Expression patterns of Nurr1 in rat retina development. Li Y, etal., J Mol Histol. 2012 Dec;43(6):633-9. doi: 10.1007/s10735-012-9433-z. Epub 2012 Jun 20.
10. Expression of Nurr1 during rat brain and spinal cord development. Li Y, etal., Neurosci Lett. 2011 Jan 13;488(1):49-54. doi: 10.1016/j.neulet.2010.10.078. Epub 2010 Nov 5.
11. Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways. Liu M, etal., Environ Toxicol. 2022 Oct;37(10):2419-2433. doi: 10.1002/tox.23607. Epub 2022 Jun 28.
12. Developmental Vitamin D (DVD) Deficiency Reduces Nurr1 and TH Expression in Post-mitotic Dopamine Neurons in Rat Mesencephalon. Luan W, etal., Mol Neurobiol. 2018 Mar;55(3):2443-2453. doi: 10.1007/s12035-017-0497-3. Epub 2017 Apr 1.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Rapid increase of Nurr1 expression in the substantia nigra after 6-hydroxydopamine lesion in the striatum of the rat. Ojeda V, etal., J Neurosci Res 2003 Sep 1;73(5):686-97.
16. HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures. Pena de Ortiz S and Jamieson GA Jr, Brain Res Mol Brain Res. 1996 May;38(1):1-13.
17. Expression of nuclear hormone receptors within the rat hippocampus: identification of novel orphan receptors. Pena de Ortiz S, etal., Brain Res Mol Brain Res 1994 May;23(3):278-83.
18. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Rajan S, etal., Nat Chem Biol. 2020 Aug;16(8):876-886. doi: 10.1038/s41589-020-0553-6. Epub 2020 May 25.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors. Sacchetti P, etal., J Biol Chem 2002 Sep 20;277(38):35088-96.
23. RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. Scearce LM, etal., J Biol Chem 1993 Apr 25;268(12):8855-61.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures. Xing G, etal., Brain Res Mol Brain Res 1997 Jul;47(1-2):251-61.
26. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. Xu PY, etal., Neurology 2002 Mar 26;58(6):881-4.
Additional References at PubMed
PMID:7877627   PMID:8889548   PMID:8961274   PMID:9092472   PMID:9520484   PMID:9608532   PMID:10465447   PMID:10523643   PMID:10585298   PMID:11113533   PMID:11517332   PMID:11749040  
PMID:12385813   PMID:12787064   PMID:12849735   PMID:12915123   PMID:14528447   PMID:14622207   PMID:14671317   PMID:14742729   PMID:15009684   PMID:15155786   PMID:15485875   PMID:15591535  
PMID:15716272   PMID:16313515   PMID:16723737   PMID:16782508   PMID:17034791   PMID:17077287   PMID:17184956   PMID:17394463   PMID:17506860   PMID:18388149   PMID:18463503   PMID:18772553  
PMID:18815614   PMID:18945812   PMID:18951485   PMID:19133164   PMID:19144721   PMID:19150624   PMID:19321449   PMID:19362551   PMID:19429166   PMID:19515692   PMID:19906978   PMID:20533997  
PMID:20566846   PMID:21663595   PMID:22525717   PMID:22627286   PMID:23566817   PMID:23624190   PMID:24399192   PMID:24584059   PMID:24940803   PMID:25815475   PMID:26497037   PMID:26873851  
PMID:27219004   PMID:27435855   PMID:27553040   PMID:27687740   PMID:27826104   PMID:29145474   PMID:29152652   PMID:29450981   PMID:29565514   PMID:30634592   PMID:30949504   PMID:31000586  
PMID:31087449   PMID:31175960   PMID:31287373   PMID:31317490   PMID:32238479   PMID:33864663   PMID:34774582   PMID:35365988   PMID:37621064  


Genomics

Comparative Map Data
Nr4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,098,739 - 62,115,926 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl362,098,743 - 62,106,769 (-)EnsemblGRCr8
mRatBN7.2341,689,847 - 41,707,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx345,028,318 - 45,033,797 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,613,078 - 53,618,558 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,404,666 - 51,410,139 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,111,258 - 43,128,391 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)Ensemblrn6Rnor6.0
Rnor_5.0348,183,106 - 48,192,467 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4338,866,205 - 38,871,678 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera339,783,304 - 39,788,777 (-)NCBICelera
RGSC_v3.1338,763,218 - 38,769,911 (-)NCBI
Cytogenetic Map3q21NCBI
NR4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382156,324,437 - 156,332,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2156,324,432 - 156,342,348 (-)Ensemblhg38GRCh38
GRCh372157,180,949 - 157,189,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362156,889,195 - 156,897,446 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342157,006,458 - 157,014,708NCBI
Celera2150,794,299 - 150,802,639 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2149,066,205 - 149,074,545 (-)NCBIHuRef
CHM1_12157,187,025 - 157,195,368 (-)NCBICHM1_1
T2T-CHM13v2.02156,777,128 - 156,785,409 (-)NCBIT2T-CHM13v2.0
Nr4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39256,996,845 - 57,014,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl256,996,842 - 57,014,015 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38257,106,830 - 57,124,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl257,106,830 - 57,124,003 (-)Ensemblmm10GRCm38
MGSCv37256,959,637 - 56,976,414 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36256,923,542 - 56,930,641 (-)NCBIMGSCv36mm8
Celera258,866,926 - 58,883,671 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Nr4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,937,794 - 16,945,731 (+)Ensembl
ChiLan1.0NW_00495544916,928,780 - 16,944,536 (+)NCBIChiLan1.0ChiLan1.0
NR4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,004,662 - 59,016,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,584,835 - 43,593,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,828,823 - 160,837,162 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,826,091 - 160,837,162 (-)EnsemblpanPan2panpan1.1
NR4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,546,237 - 2,554,559 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,547,421 - 2,552,780 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha362,678,764 - 2,696,690 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0362,664,920 - 2,682,769 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,665,580 - 2,671,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,663,962 - 2,681,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,724,009 - 2,741,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,763,654 - 2,781,495 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303119,697,239 - 119,705,622 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,912,047 - 21,920,486 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,912,118 - 21,920,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1563,487,731 - 63,495,299 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11563,487,051 - 63,506,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21570,671,034 - 70,689,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11041,715,092 - 41,724,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1041,715,086 - 41,723,685 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040157,834,500 - 157,843,891 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247329,581,779 - 9,589,942 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247329,572,160 - 9,589,624 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr4a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1535,007,778 - 35,024,884 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr4a2
107 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:60
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000041394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat

Markers in Region
D3Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,690,710 - 41,690,851 (+)MAPPERmRatBN7.2
Rnor_6.0343,112,122 - 43,112,262NCBIRnor6.0
Rnor_5.0348,183,970 - 48,184,110UniSTSRnor5.0
RGSC_v3.4338,866,394 - 38,866,534UniSTSRGSC3.4
Celera339,783,493 - 39,783,633UniSTS
Cytogenetic Map3q12UniSTS
RH138091  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,690,619 - 41,690,749 (+)MAPPERmRatBN7.2
Rnor_6.0343,112,031 - 43,112,160NCBIRnor6.0
Rnor_5.0348,183,879 - 48,184,008UniSTSRnor5.0
RGSC_v3.4338,866,303 - 38,866,432UniSTSRGSC3.4
Celera339,783,402 - 39,783,531UniSTS
RH 3.4 Map3538.0UniSTS
Cytogenetic Map3q12UniSTS
PMC109903P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8362,100,503 - 62,101,177 (+)Marker Load Pipeline
mRatBN7.2341,691,611 - 41,692,285 (+)MAPPERmRatBN7.2
Rnor_6.0343,113,023 - 43,113,696NCBIRnor6.0
Rnor_5.0348,184,871 - 48,185,544UniSTSRnor5.0
RGSC_v3.4338,867,295 - 38,867,968UniSTSRGSC3.4
Celera339,784,394 - 39,785,067UniSTS
Cytogenetic Map3q12UniSTS
Nr4a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8362,100,307 - 62,100,534 (+)Marker Load Pipeline
mRatBN7.2341,691,415 - 41,691,642 (+)MAPPERmRatBN7.2
Rnor_6.0343,112,827 - 43,113,053NCBIRnor6.0
Rnor_5.0348,184,675 - 48,184,901UniSTSRnor5.0
RGSC_v3.4338,867,099 - 38,867,325UniSTSRGSC3.4
Celera339,784,198 - 39,784,424UniSTS
Cytogenetic Map3q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AW534944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB606493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041394   ⟹   ENSRNOP00000043812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,098,743 - 62,106,769 (-)Ensembl
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)Ensembl
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078001   ⟹   ENSRNOP00000072142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,100,078 - 62,104,818 (-)Ensembl
mRatBN7.2 Ensembl341,691,186 - 41,695,926 (-)Ensembl
Rnor_6.0 Ensembl343,112,597 - 43,117,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159798   ⟹   ENSRNOP00000111539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,099,688 - 62,106,748 (-)Ensembl
RefSeq Acc Id: NM_019328   ⟹   NP_062201
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,099,414 - 62,104,887 (-)NCBI
mRatBN7.2341,690,522 - 41,695,995 (-)NCBI
Rnor_6.0343,111,933 - 43,117,406 (-)NCBI
Rnor_5.0348,183,106 - 48,192,467 (-)NCBI
RGSC_v3.4338,866,205 - 38,871,678 (-)RGD
Celera339,783,304 - 39,788,777 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234201   ⟹   XP_006234263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,106,684 (-)NCBI
mRatBN7.2341,689,847 - 41,697,856 (-)NCBI
Rnor_6.0343,111,933 - 43,122,218 (-)NCBI
Rnor_5.0348,183,106 - 48,192,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591997   ⟹   XP_017447486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,115,926 (-)NCBI
mRatBN7.2341,689,847 - 41,707,036 (-)NCBI
Rnor_6.0343,111,933 - 43,128,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105737   ⟹   XP_038961665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,106,303 (-)NCBI
mRatBN7.2341,689,847 - 41,697,444 (-)NCBI
RefSeq Acc Id: XM_039105738   ⟹   XP_038961666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,106,684 (-)NCBI
mRatBN7.2341,689,847 - 41,697,790 (-)NCBI
RefSeq Acc Id: XM_063284415   ⟹   XP_063140485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,100,483 - 62,106,684 (-)NCBI
RefSeq Acc Id: XM_063284416   ⟹   XP_063140486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,100,483 - 62,106,684 (-)NCBI
RefSeq Acc Id: NP_062201   ⟸   NM_019328
- UniProtKB: O35865 (UniProtKB/Swiss-Prot),   Q07917 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234263   ⟸   XM_006234201
- Peptide Label: isoform X1
- UniProtKB: O35865 (UniProtKB/Swiss-Prot),   Q07917 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447486   ⟸   XM_017591997
- Peptide Label: isoform X1
- UniProtKB: O35865 (UniProtKB/Swiss-Prot),   Q07917 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043812   ⟸   ENSRNOT00000041394
Ensembl Acc Id: ENSRNOP00000072142   ⟸   ENSRNOT00000078001
RefSeq Acc Id: XP_038961666   ⟸   XM_039105738
- Peptide Label: isoform X2
- UniProtKB: Q07917 (UniProtKB/Swiss-Prot),   O35865 (UniProtKB/Swiss-Prot),   Q3LZI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961665   ⟸   XM_039105737
- Peptide Label: isoform X1
- UniProtKB: Q07917 (UniProtKB/Swiss-Prot),   O35865 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140486   ⟸   XM_063284416
- Peptide Label: isoform X4
- UniProtKB: Q3LZI8 (UniProtKB/TrEMBL),   Q3LZI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140485   ⟸   XM_063284415
- Peptide Label: isoform X3
- UniProtKB: Q3LZI9 (UniProtKB/TrEMBL),   Q3LZI7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111539   ⟸   ENSRNOT00000159798
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07917-F1-model_v2 AlphaFold Q07917 1-598 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692082
Promoter ID:EPDNEW_R2607
Type:initiation region
Name:Nr4a2_1
Description:nuclear receptor subfamily 4, group A, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0343,119,258 - 43,119,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3202 AgrOrtholog
BioCyc Gene G2FUF-49671 BioCyc
Ensembl Genes ENSRNOG00000005600 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041394 ENTREZGENE
  ENSRNOT00000078001 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nuc_orph_rcpt UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  NURR_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:54278 UniProtKB/Swiss-Prot
NCBI Gene 54278 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr4a2 PhenoGen
PRINTS NUCLEARECPTR UniProtKB/Swiss-Prot
  NURRNUCRCPTR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005600 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC233109
UniProt A0A0G2JSV4_RAT UniProtKB/TrEMBL
  A0ABK0M7P8_RAT UniProtKB/TrEMBL
  A6JF46 ENTREZGENE, UniProtKB/TrEMBL
  NR4A2_RAT UniProtKB/Swiss-Prot
  O35865 ENTREZGENE
  Q07917 ENTREZGENE
  Q3LZI4 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI5 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI7 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI8 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35865 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr4a2  nuclear receptor subfamily 4, group A, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction heterodimerizes with retinoic X receptor (RXR)and binds direct repeat response elements 727393