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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a2affects localizationISONr4a2 (Mus musculus)6480464CTDsodium arsenite affects the localization of NR4A2 proteinPMID:23283970
Nr4a2decreases expressionISONR4A2 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of NR4A2 mRNAPMID:29301061
Nr4a2decreases expressionISONr4a2 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of NR4A2 mRNAPMID:18812580
Nr4a2multiple interactionsISONr4a2 (Mus musculus)6480464CTD[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of DDC mRNA]; [sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of SLC18A2 mRNA]; [sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of TH mRNA]; leptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein]PMID:23283970
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