NR4A2 (nuclear receptor subfamily 4 group A member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: NR4A2 (nuclear receptor subfamily 4 group A member 2) Pan paniscus
Analyze
Symbol: NR4A2
Name: nuclear receptor subfamily 4 group A member 2
RGD ID: 12026151
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN adult locomotory behavior (ortholog); cellular response to extracellular stimulus (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,004,662 - 59,016,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,584,835 - 43,593,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,828,823 - 160,837,162 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,826,091 - 160,837,162 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IEA,ISO)
cellular response to corticotropin-releasing hormone stimulus  (IEA)
cellular response to extracellular stimulus  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
central nervous system neuron differentiation  (IEA,ISO)
central nervous system projection neuron axonogenesis  (IEA,ISO)
cerebral cortex development  (ISO)
DNA-templated transcription  (IEA)
dopamine biosynthetic process  (IEA,ISO)
dopamine metabolic process  (IEA,ISO)
dopaminergic neuron differentiation  (IEA,ISO)
fat cell differentiation  (IEA)
gene expression  (IEA,ISO)
general adaptation syndrome  (IEA,ISO)
habenula development  (IEA,ISO)
intracellular receptor signaling pathway  (IEA)
learning or memory  (ISO)
negative regulation of apoptotic signaling pathway  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
nervous system development  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuron maturation  (IEA,ISO)
neuron migration  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
post-embryonic development  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of respiratory gaseous exchange  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to amphetamine  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to inorganic substance  (ISO)
response to insecticide  (ISO)
retina development in camera-type eye  (ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NR4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,004,662 - 59,016,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,584,835 - 43,593,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,828,823 - 160,837,162 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,826,091 - 160,837,162 (-)Ensemblpanpan1.1panPan2
NR4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382156,324,437 - 156,332,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2156,324,437 - 156,342,348 (-)EnsemblGRCh38hg38GRCh38
GRCh372157,180,949 - 157,189,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362156,889,195 - 156,897,446 (-)NCBINCBI36Build 36hg18NCBI36
Build 342157,006,458 - 157,014,708NCBI
Celera2150,794,299 - 150,802,639 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2149,066,205 - 149,074,545 (-)NCBIHuRef
CHM1_12157,187,025 - 157,195,368 (-)NCBICHM1_1
T2T-CHM13v2.02156,777,128 - 156,785,409 (-)NCBIT2T-CHM13v2.0
Nr4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39256,996,845 - 57,014,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl256,996,842 - 57,014,015 (-)EnsemblGRCm39 Ensembl
GRCm38257,106,830 - 57,124,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl257,106,830 - 57,124,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv37256,959,637 - 56,976,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36256,923,542 - 56,930,641 (-)NCBIMGSCv36mm8
Celera258,866,926 - 58,883,671 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Nr4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,098,739 - 62,115,926 (-)NCBIGRCr8
mRatBN7.2341,689,847 - 41,707,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,028,318 - 45,033,797 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,613,078 - 53,618,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,404,666 - 51,410,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,111,258 - 43,128,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0348,183,106 - 48,192,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4338,866,205 - 38,871,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1338,763,218 - 38,769,911 (-)NCBI
Celera339,783,304 - 39,788,777 (-)NCBICelera
Cytogenetic Map3q21NCBI
Nr4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,937,794 - 16,945,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544916,928,780 - 16,944,536 (+)NCBIChiLan1.0ChiLan1.0
NR4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,546,237 - 2,554,559 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,547,421 - 2,552,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha362,678,764 - 2,696,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,664,920 - 2,682,769 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,665,580 - 2,671,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,663,962 - 2,681,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,724,009 - 2,741,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,763,654 - 2,781,495 (-)NCBIUU_Cfam_GSD_1.0
Nr4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303119,697,239 - 119,705,622 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,912,047 - 21,920,486 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,912,118 - 21,920,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1563,487,731 - 63,495,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11563,487,051 - 63,506,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21570,671,034 - 70,689,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11041,715,092 - 41,724,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1041,715,086 - 41,723,685 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040157,834,500 - 157,843,891 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247329,581,779 - 9,589,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247329,572,160 - 9,589,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000040159   ⟹   ENSPPAP00000017455
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B160,826,091 - 160,835,177 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040167   ⟹   ENSPPAP00000017463
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B160,828,823 - 160,837,162 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040184   ⟹   ENSPPAP00000017480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B160,830,129 - 160,834,570 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040195   ⟹   ENSPPAP00000017490
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B160,830,160 - 160,834,570 (-)Ensembl
RefSeq Acc Id: XM_003832715   ⟹   XP_003832763
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBI
NHGRI_mPanPan12B59,004,663 - 59,016,460 (-)NCBI
Mhudiblu_PPA_v02B43,584,835 - 43,593,118 (-)NCBI
PanPan1.12B160,828,823 - 160,837,162 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003832717   ⟹   XP_003832765
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBI
NHGRI_mPanPan12B59,004,662 - 59,016,460 (-)NCBI
Mhudiblu_PPA_v02B43,584,835 - 43,593,116 (-)NCBI
PanPan1.12B160,829,491 - 160,837,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055108597   ⟹   XP_054964572
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21358,995,014 - 59,002,614 (-)NCBI
NHGRI_mPanPan12B59,009,988 - 59,016,460 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003832763   ⟸   XM_003832715
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AK54 (UniProtKB/TrEMBL),   A0A2R9AP42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003832765   ⟸   XM_003832717
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AP42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000017463   ⟸   ENSPPAT00000040167
RefSeq Acc Id: ENSPPAP00000017480   ⟸   ENSPPAT00000040184
RefSeq Acc Id: ENSPPAP00000017490   ⟸   ENSPPAT00000040195
RefSeq Acc Id: ENSPPAP00000017455   ⟸   ENSPPAT00000040159
RefSeq Acc Id: XP_054964572   ⟸   XM_055108597
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AP49 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031796 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040159.1 UniProtKB/TrEMBL
  ENSPPAT00000040167.1 UniProtKB/TrEMBL
  ENSPPAT00000040184.1 UniProtKB/TrEMBL
  ENSPPAT00000040195.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  Nuc_orph_rcpt UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  NURR_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report pps:100971338 UniProtKB/TrEMBL
NCBI Gene NR4A2 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2 UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS NUCLEARECPTR UniProtKB/TrEMBL
  NURRNUCRCPTR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A2R9AK54 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AP22_PANPA UniProtKB/TrEMBL
  A0A2R9AP42 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AP49 ENTREZGENE, UniProtKB/TrEMBL