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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a2affects expressionEXP 6480464CTDPermethrin affects the expression of NR4A2 mRNAPMID:23566817
Nr4a2decreases expressionEXP 6480464CTDPermethrin results in decreased expression of NR4A2; Permethrin results in decreased expression of NR4A2 mRNA; Permethrin results in decreased expression of NR4A2 proteinPMID:22056222 PMID:23174539 PMID:25048945
Nr4a2increases expressionEXP 6480464CTDPermethrin results in increased expression of NR4A2 mRNA; Permethrin results in increased expression of NR4A2 proteinPMID:23566817 PMID:28943456 PMID:29051472 PMID:31175960
Nr4a2multiple interactionsEXP 6480464CTDGlutathione inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA]; Tocotrienols inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA]PMID:28943456
Nr4a2affects bindingISONR4A2 (Homo sapiens)6480464CTDPermethrin binds to [NR4A2 protein binds to NR4A2 protein]PMID:31175960
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