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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of NR4A2 mRNAPMID:34747641
Nr4a2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NR4A2 mRNAPMID:32109520 PMID:33387578
Nr4a2affects expressionISONr4a2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NR4A2 mRNAPMID:21570461 PMID:24058054
Nr4a2decreases expressionISONR4A2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NR4A2 mRNAPMID:29704546
Nr4a2multiple interactionsISONR4A2 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of NR4A2 mRNAPMID:29704546
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