Nr4a2 (nuclear receptor subfamily 4 group A member 2) - Rat Genome Database

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Gene: Nr4a2 (nuclear receptor subfamily 4 group A member 2) Chinchilla lanigera
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Symbol: Nr4a2
Name: nuclear receptor subfamily 4 group A member 2
RGD ID: 8762274
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); nuclear glucocorticoid receptor binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular response to corticotropin-releasing hormone stimulus (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); nuclear speck (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear receptor subfamily 4, group A, member 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,937,794 - 16,945,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544916,928,780 - 16,944,536 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISO)
nuclear speck  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nr4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,937,794 - 16,945,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544916,928,780 - 16,944,536 (+)NCBIChiLan1.0ChiLan1.0
NR4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382156,324,437 - 156,332,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2156,324,437 - 156,342,348 (-)EnsemblGRCh38hg38GRCh38
GRCh372157,180,949 - 157,189,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362156,889,195 - 156,897,446 (-)NCBINCBI36Build 36hg18NCBI36
Build 342157,006,458 - 157,014,708NCBI
Celera2150,794,299 - 150,802,639 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2149,066,205 - 149,074,545 (-)NCBIHuRef
CHM1_12157,187,025 - 157,195,368 (-)NCBICHM1_1
T2T-CHM13v2.02156,777,128 - 156,785,409 (-)NCBIT2T-CHM13v2.0
Nr4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39256,996,845 - 57,014,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl256,996,842 - 57,014,015 (-)EnsemblGRCm39 Ensembl
GRCm38257,106,830 - 57,124,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl257,106,830 - 57,124,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv37256,959,637 - 56,976,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36256,923,542 - 56,930,641 (-)NCBIMGSCv36mm8
Celera258,866,926 - 58,883,671 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Nr4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,098,739 - 62,115,926 (-)NCBIGRCr8
mRatBN7.2341,689,847 - 41,707,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,028,318 - 45,033,797 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,613,078 - 53,618,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,404,666 - 51,410,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,111,258 - 43,128,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0348,183,106 - 48,192,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4338,866,205 - 38,871,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1338,763,218 - 38,769,911 (-)NCBI
Celera339,783,304 - 39,788,777 (-)NCBICelera
Cytogenetic Map3q21NCBI
NR4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,004,662 - 59,016,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,584,835 - 43,593,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,828,823 - 160,837,162 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,826,091 - 160,837,162 (-)Ensemblpanpan1.1panPan2
NR4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,546,237 - 2,554,559 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,547,421 - 2,552,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha362,678,764 - 2,696,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,664,920 - 2,682,769 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,665,580 - 2,671,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,663,962 - 2,681,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,724,009 - 2,741,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,763,654 - 2,781,495 (-)NCBIUU_Cfam_GSD_1.0
Nr4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303119,697,239 - 119,705,622 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,912,047 - 21,920,486 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,912,118 - 21,920,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1563,487,731 - 63,495,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11563,487,051 - 63,506,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21570,671,034 - 70,689,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11041,715,092 - 41,724,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1041,715,086 - 41,723,685 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040157,834,500 - 157,843,891 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247329,581,779 - 9,589,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247329,572,160 - 9,589,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000004709   ⟹   ENSCLAP00000004623
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544916,937,794 - 16,945,731 (+)Ensembl
RefSeq Acc Id: XM_005393416   ⟹   XP_005393473
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544916,937,514 - 16,944,536 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005393417   ⟹   XP_005393474
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544916,937,514 - 16,944,536 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005393418   ⟹   XP_005393475
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544916,937,794 - 16,944,536 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005393419   ⟹   XP_005393476
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544916,928,780 - 16,944,536 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013518806   ⟹   XP_013374260
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544916,937,513 - 16,944,246 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001235828
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544916,937,514 - 16,944,126 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005393476   ⟸   XM_005393419
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005393473   ⟸   XM_005393416
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005393474   ⟸   XM_005393417
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005393475   ⟸   XM_005393418
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013374260   ⟸   XM_013518806
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000004623   ⟸   ENSCLAT00000004709
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003290 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004709 ENTREZGENE
  ENSCLAT00000004709.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  Nuc_orph_rcpt UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  NURR_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr4a2 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2 UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS NUCLEARECPTR UniProtKB/TrEMBL
  NURRNUCRCPTR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A8C2UUW5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nr4a2  nuclear receptor subfamily 4 group A member 2    nuclear receptor subfamily 4, group A, member 2  Symbol and/or name change 5135510 APPROVED