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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a2increases expressionISONR4A2 (Homo sapiens)6480464CTDColforsin results in increased expression of NR4A2 mRNA; Colforsin results in increased expression of NR4A2 proteinPMID:19732956 PMID:26023867
Nr4a2multiple interactionsISONR4A2 (Homo sapiens)6480464CTD666-15 compound inhibits the reaction [Colforsin results in increased expression of NR4A2 mRNA]; NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]PMID:19822197 PMID:26023867
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