Hk2 (hexokinase 2) - Rat Genome Database

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Gene: Hk2 (hexokinase 2) Rattus norvegicus
Analyze
Symbol: Hk2
Name: hexokinase 2
RGD ID: 2797
Description: Enables ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including carbohydrate phosphorylation; lactation; and response to ischemia. Located in cytosol and sarcoplasmic reticulum. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2); PARTICIPATES IN altered carbohydrate metabolic pathway; congenital sucrase-isomaltase deficiency pathway; Fanconi syndrome pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hexokinase type II; hexokinase-2; hexokinase-B; HK II; type II hexokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,792,258 - 116,841,275 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4116,792,258 - 116,841,275 (-)EnsemblGRCr8
mRatBN7.24115,234,509 - 115,283,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4120,703,515 - 120,752,497 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,478,737 - 116,527,715 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,100,199 - 115,149,197 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,559,396 - 113,609,897 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)Ensemblrn6Rnor6.0
Rnor_5.04178,237,866 - 178,288,251 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44116,925,725 - 116,975,211 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4104,230,959 - 104,279,831 (-)NCBICelera
RGSC_v3.14117,170,205 - 117,219,692 (-)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chlorobiphenyl  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
AP20187  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
bicalutamide  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bruceine D  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carteolol  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
drometrizole  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
GSK-J4  (ISO)
heptachlor  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
metyrapone  (EXP)
microcystin-LR  (ISO)
mirex  (EXP)
myricetin  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
promethazine  (EXP)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
roxadustat  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
trametinib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IDA,IEA,ISO)
mitochondrial outer membrane  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)
sarcoplasmic reticulum  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Reduced expression of hexokinase II in insulin-resistant diabetes. Braithwaite SS, etal., Diabetes. 1995 Jan;44(1):43-8.
2. Evolution and regulatory role of the hexokinases. Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
3. Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes. Cusi KJ, etal., Metabolism. 2001 May;50(5):602-6.
4. Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats. Ferrer-Martinez A, etal., Lipids. 2006 Jan;41(1):55-62.
5. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
6. Initial rate and isotope exchange studies of rat skeletal muscle hexokinase. Ganson NJ and Fromm HJ, J Biol Chem. 1985 Oct 5;260(22):12099-105.
7. Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as Revealed by 1H-NMR-Based Metabolic Profiling. Gao J, etal., Front Pharmacol. 2019 Sep 11;10:989. doi: 10.3389/fphar.2019.00989. eCollection 2019.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Multiple molecular forms of ATP:hexose 6-phosphotransferase from rat liver. González C, etal., Biochem Biophys Res Commun. 1964 Jul 1;16(4):347-52. doi: 10.1016/0006-291x(64)90038-5.
11. Isotope-exchange evidence that glucose 6-phosphate inhibits rat-muscle hexokinase II at an allosteric site. Gregoriou M, etal., Eur J Biochem. 1983 Aug 1;134(2):283-8.
12. Nucleotide sequence of the 5'-flanking region of the rat type II hexokinase gene. Ichihara J, etal., Biochim Biophys Acta 1995 Feb 21;1260(3):365-8.
13. Expression of hexokinase 1 and hexokinase 2 in mammary tissue of nonlactating and lactating rats: evaluation by RT-PCR. Kaselonis GL, etal., Mol Genet Metab. 1999 Nov;68(3):371-4.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Majewski N, etal., Mol Cell 2004 Dec 3;16(5):819-30.
16. Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. Mathupala SP, etal., J Biol Chem 1995 Jul 14;270(28):16918-25.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
20. The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Pasdois P, etal., Biochem J. 2011 Jun 1;436(2):493-505. doi: 10.1042/BJ20101957.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Hexokinase II mRNA and gene structure, regulation by insulin, and evolution. Printz RL, etal., J Biol Chem 1993 Mar 5;268(7):5209-19.
25. Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages. Rempel A, etal., Biochim Biophys Acta. 1994 Nov 22;1219(3):660-8. doi: 10.1016/0167-4781(94)90225-9.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor. Thelen AP and Wilson JE, Arch Biochem Biophys 1991 May 1;286(2):645-51.
30. Functional organization of mammalian hexokinases: both N- and C-terminal halves of the rat type II isozyme possess catalytic sites. Tsai HJ and Wilson JE, Arch Biochem Biophys. 1996 May 1;329(1):17-23.
31. Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium. Waskova-Arnostova P, etal., Cell Physiol Biochem. 2014;33(2):310-20. doi: 10.1159/000356671. Epub 2014 Jan 31.
Additional References at PubMed
PMID:10428828   PMID:11068878   PMID:12566445   PMID:14701745   PMID:16551620   PMID:16951044   PMID:17516843   PMID:17639019   PMID:18165236   PMID:18350175   PMID:18614015   PMID:19228992  
PMID:19681047   PMID:19946888   PMID:20439489   PMID:21049555   PMID:21408025   PMID:22517678   PMID:22627259   PMID:23525412   PMID:23962723   PMID:24462113   PMID:25801897   PMID:26316108  
PMID:26985301   PMID:28258543   PMID:28290047   PMID:28522551   PMID:29205357   PMID:29298880   PMID:30391711   PMID:31573845   PMID:32415544   PMID:32495363   PMID:32579577   PMID:37715611  
PMID:38531963  


Genomics

Comparative Map Data
Hk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,792,258 - 116,841,275 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4116,792,258 - 116,841,275 (-)EnsemblGRCr8
mRatBN7.24115,234,509 - 115,283,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4120,703,515 - 120,752,497 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,478,737 - 116,527,715 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,100,199 - 115,149,197 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,559,396 - 113,609,897 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)Ensemblrn6Rnor6.0
Rnor_5.04178,237,866 - 178,288,251 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44116,925,725 - 116,975,211 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4104,230,959 - 104,279,831 (-)NCBICelera
RGSC_v3.14117,170,205 - 117,219,692 (-)NCBI
Cytogenetic Map4q34NCBI
HK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,834,127 - 74,893,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,834,079 - 74,893,359 (+)Ensemblhg38GRCh38
GRCh37275,061,254 - 75,120,486 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,913,290 - 74,973,989 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34274,971,436 - 75,032,134NCBI
Celera274,890,867 - 74,951,557 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef274,796,877 - 74,857,297 (+)NCBIHuRef
CHM1_1274,989,111 - 75,049,797 (+)NCBICHM1_1
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBIT2T-CHM13v2.0
Hk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,702,004 - 82,751,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,702,006 - 82,751,435 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38682,725,025 - 82,774,454 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,725,025 - 82,774,454 (-)Ensemblmm10GRCm38
MGSCv37682,675,019 - 82,724,448 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36682,690,705 - 82,740,117 (-)NCBIMGSCv36mm8
Celera684,700,692 - 84,750,369 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Hk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,897,485 - 10,966,025 (-)Ensembl
ChiLan1.0NW_00495542410,897,528 - 10,966,025 (-)NCBIChiLan1.0ChiLan1.0
HK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,498,596 - 51,561,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,501,345 - 51,563,782 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,897,914 - 74,957,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,400,240 - 76,460,881 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,400,240 - 76,460,874 (+)EnsemblpanPan2panpan1.1
HK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,287,367 - 48,329,470 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,289,272 - 48,348,663 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1747,929,800 - 47,991,763 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01749,149,327 - 49,211,264 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,149,338 - 49,211,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,164,479 - 48,226,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,228,923 - 48,290,663 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,791,741 - 48,853,532 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,624,471 - 9,683,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,054,021 - 1,113,450 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,054,143 - 1,113,425 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,153,835 - 68,231,615 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1368,155,656 - 68,231,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,331,772 - 71,407,448 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,385,237 - 32,443,864 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,385,249 - 32,442,403 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604579,732,113 - 79,789,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,618,030 - 28,689,794 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474928,618,146 - 28,718,852 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1663,447,720 - 63,497,609 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hk2
220 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:505
Count of miRNA genes:251
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000008813
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 354 192 11 140 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008813   ⟹   ENSRNOP00000008813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4116,792,258 - 116,841,275 (-)Ensembl
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)Ensembl
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109070   ⟹   ENSRNOP00000090099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4116,792,258 - 116,841,275 (-)Ensembl
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)Ensembl
RefSeq Acc Id: NM_012735   ⟹   NP_036867
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84116,792,258 - 116,841,275 (-)NCBI
mRatBN7.24115,234,509 - 115,283,530 (-)NCBI
Rnor_6.04113,560,880 - 113,609,897 (-)NCBI
Rnor_5.04178,237,866 - 178,288,251 (-)NCBI
RGSC_v3.44116,925,725 - 116,975,211 (-)RGD
Celera4104,230,959 - 104,279,831 (-)RGD
Sequence:
RefSeq Acc Id: NP_036867   ⟸   NM_012735
- UniProtKB: Q9QWR1 (UniProtKB/Swiss-Prot),   P27881 (UniProtKB/Swiss-Prot),   A6IAI1 (UniProtKB/TrEMBL),   O54892 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008813   ⟸   ENSRNOT00000008813
Ensembl Acc Id: ENSRNOP00000090099   ⟸   ENSRNOT00000109070
Protein Domains
Hexokinase   Hexokinase C-terminal   Hexokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27881-F1-model_v2 AlphaFold P27881 1-917 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693160
Promoter ID:EPDNEW_R3685
Type:initiation region
Name:Hk2_1
Description:hexokinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04113,610,185 - 113,610,245EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2797 AgrOrtholog
BioCyc Gene G2FUF-44043 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY-3861 [mannitol degradation II] BioCyc
  PWY-5941 [glycogen degradation II] BioCyc
  PWY3O-1743 [D-mannose degradation II] BioCyc
  UDPNACETYLGALSYN-PWY [UDP-N-acetyl-D-glucosamine biosynthesis II] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY-3861 BioCyc
  PWY-5941 BioCyc
  PWY3O-1743 BioCyc
  UDPNACETYLGALSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000006116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008813 ENTREZGENE
  ENSRNOT00000008813.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  3.40.367.20 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Hexokinase UniProtKB/Swiss-Prot
  Hexokinase_BS UniProtKB/Swiss-Prot
  Hexokinase_C UniProtKB/Swiss-Prot
  Hexokinase_N UniProtKB/Swiss-Prot
KEGG Report rno:25059 UniProtKB/Swiss-Prot
NCBI Gene 25059 ENTREZGENE
PANTHER HEXOKINASE-2 UniProtKB/Swiss-Prot
  PTHR19443 UniProtKB/Swiss-Prot
Pfam Hexokinase_1 UniProtKB/Swiss-Prot
  Hexokinase_2 UniProtKB/Swiss-Prot
PhenoGen Hk2 PhenoGen
PRINTS HEXOKINASE UniProtKB/Swiss-Prot
PROSITE HEXOKINASE_1 UniProtKB/Swiss-Prot
  HEXOKINASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006116 RatGTEx
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8I6GIL6_RAT UniProtKB/TrEMBL
  A6IAI1 ENTREZGENE, UniProtKB/TrEMBL
  HXK2_RAT UniProtKB/Swiss-Prot
  O54892 ENTREZGENE, UniProtKB/TrEMBL
  P27881 ENTREZGENE
  Q9QWR1 ENTREZGENE
UniProt Secondary Q9QWR1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hk2  Hexokinase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein a protein of 103 kDa 632919
gene_regulation mRNA expression is induced by insulin 632919