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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hk2
Name: hexokinase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hk2increases expressionEXP 6480464CTDDoxorubicin results in increased expression of HK2 mRNAPMID:19915844
Hk2decreases expressionISOHK2 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of HK2 mRNA; Doxorubicin results in decreased expression of HK2 proteinPMID:16595493
Hk2decreases expressionISOHk2 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of HK2 mRNA; Doxorubicin results in decreased expression of HK2 proteinPMID:26873546 PMID:29653124
Hk2increases expressionISOHK2 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of HK2 mRNAPMID:29803840
Hk2multiple interactionsISOHK2 (Homo sapiens)6480464CTDDoxorubicin inhibits the reaction [Deferoxamine results in increased expression of HK2 protein]PMID:34126102
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