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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hk2
Name: hexokinase 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hk2decreases expressionISOHK2 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of HK2 mRNAPMID:21540303
Hk2increases expressionISOHk2 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of HK2 proteinPMID:36762617
Hk2multiple interactionsISOHk2 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of HK2 protein; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of HK2 protein]]; NOX4 protein affects the reaction [Lipopolysaccharides results in increased expression of HK2 protein]; NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of HK2 protein]PMID:36762617
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