Cycs (cytochrome c, somatic) - Rat Genome Database

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Gene: Cycs (cytochrome c, somatic) Rattus norvegicus
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Symbol: Cycs (Ensembl: Cycs-ps9)
Name: cytochrome c, somatic (Ensembl:cytochrome c, somatic, pseudogene 9)
RGD ID: 2451
Description: Enables enzyme binding activity. Involved in several processes, including mitochondrial electron transport, cytochrome c to oxygen; negative regulation of hydrogen peroxide biosynthetic process; and response to ischemia. Located in cytosol. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic); PARTICIPATES IN intrinsic apoptotic pathway; cardiolipin metabolic pathway; ceramide signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-epigallocatechin 3-gallate; (R)-adrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYCSA; Cytochrome C expressed in somatic tissues; Cytochrome C, expressed in somatic tissues; MGC93634
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Cycs-ps9   LOC120098911  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,982,667 - 80,984,767 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1862,552,743 - 62,553,968 (-)EnsemblGRCr8
GRCr8 Ensembl480,982,668 - 80,984,816 (-)EnsemblGRCr8
mRatBN7.2479,651,894 - 79,653,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,651,378 - 79,654,054 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1860,282,810 - 60,284,019 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,869,367 - 84,871,467 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,644,890 - 80,646,990 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0479,085,223 - 79,087,323 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0480,331,226 - 80,333,326 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl480,331,227 - 80,333,326 (-)Ensemblrn6Rnor6.0
Rnor_5.04145,002,156 - 145,004,256 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,825,878 - 78,827,978 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera474,558,589 - 74,560,689 (-)NCBICelera
RGSC_v3.1479,102,008 - 79,104,108 (-)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-taxifolin  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-bromohexadecanoic acid  (ISO)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-formylpterin  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9H-xanthine  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alloxan  (EXP)
Allyl chloride  (EXP)
Aloe emodin  (ISO)
alpha-mangostin  (ISO)
alpinumisoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
anastrozole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
apigenin  (EXP,ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Aspidin  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP,ISO)
Augmentin  (EXP)
aureusidin  (ISO)
azadirachtin A  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP)
Bavachinin  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
betaxolol  (ISO)
bexarotene  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
brequinar  (ISO)
bromobenzene  (EXP)
bruceine D  (ISO)
bufalin  (ISO)
buserelin  (ISO)
butachlor  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cabazitaxel  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (ISO)
caffeine  (ISO)
cajanol  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
carbamazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carvedilol  (EXP)
casticin  (ISO)
celastrol  (ISO)
ceritinib  (ISO)
chlorpyrifos  (ISO)
Cholestane-3,5,6-triol  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
ciprofloxacin  (EXP)
cisplatin  (EXP,ISO)
Clivoline  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP)
colistin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
corosolic acid  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
crotonaldehyde  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
daunorubicin  (ISO)
DDE  (EXP)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
dicoumarol  (EXP)
dicrotophos  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echinocystic acid  (ISO)
edaravone  (EXP)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
enalapril  (EXP)
endosulfan  (ISO)
endrin  (ISO)
entinostat  (ISO)
equol  (ISO)
erdosteine  (ISO)
eriodictyol  (ISO)
esculetin  (ISO)
ethanol  (ISO)
ethylbenzene  (EXP)
etoposide  (ISO)
eugenol  (EXP,ISO)
euscaphic acid  (ISO)
everolimus  (EXP)
fenofibrate  (ISO)
fipronil  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Garcinol  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Gentiopicrin  (ISO)
ginsenoside Rd  (EXP)
glabridin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (EXP)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
Grifolin  (ISO)
heptachlor  (EXP)
hesperetin  (EXP,ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hyperforin  (EXP,ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
Ioversol  (EXP)
isatin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
JBIR-99  (ISO)
kaempferol  (ISO)
kainic acid  (EXP,ISO)
ketoconazole  (EXP)
KN-93  (ISO)
L-ascorbic acid  (ISO)
L-dehydroascorbic acid  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
letrozole  (ISO)
leuprolide  (EXP,ISO)
levetiracetam  (EXP)
limonene  (EXP)
linoleic acid  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
Longikaurin A  (ISO)
losartan  (EXP)
LY294002  (ISO)
magnesium oxide  (ISO)
mancozeb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methylglyoxal  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
miconazole  (EXP)
mifepristone  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
Mitoquinone  (EXP)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
morin  (EXP)
morphine  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-phosphocreatine  (EXP)
naphthalene  (ISO)
naringin  (ISO)
nelfinavir  (ISO)
neocuproine  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitric oxide  (EXP,ISO)
Norethindrone enanthate  (EXP)
nortriptyline  (ISO)
norwogonin  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 168393  (ISO)
pefloxacin  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
phytosphingosine  (ISO)
pifithrin-alpha hydrobromide  (EXP)
piperine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
potassium iodide  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP)
propetamphos  (EXP)
propofol  (ISO)
protoporphyrin  (EXP)
Pseudolaric acid B  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (EXP,ISO)
rocaglamide  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
safrole  (ISO)
salubrinal  (ISO)
Salvianolic acid A  (EXP)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SNX-2112  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
Suillin  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
taurine  (EXP)
tebufenpyrad  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
TEMPO  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
tigecycline  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
torcetrapib  (ISO)
Tormentic acid  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylenediamine  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursolic acid  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
Vernodalol  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
wortmannin  (EXP)
Xanthorrhizol  (ISO)
xestospongin C  (EXP)
xylitol  (ISO)
zearalenone  (ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zingiberene  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. Atlante A, etal., J Biol Chem. 2000 Nov 24;275(47):37159-66.
2. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
3. Hematoporphyrin derivative-mediated photodynamic therapy inhibits tumor growth in human cholangiocarcinoma in vitro and in vivo. Cao LQ, etal., Hepatol Res. 2009 Dec;39(12):1190-7. Epub 2009 Sep 25.
4. Mutations of cytochrome c identified in patients with thrombocytopenia THC4 affect both apoptosis and cellular bioenergetics. De Rocco D, etal., Biochim Biophys Acta. 2014 Feb;1842(2):269-74. doi: 10.1016/j.bbadis.2013.12.002. Epub 2013 Dec 8.
5. Circular dichroism studies of the binding of mammalian and non-mammalian cytochromes c to cytochrome c oxidase, cytochrome c peroxidase, and polyanions. Garber EA and Margoliash E, Biochim Biophys Acta. 1994 Sep 27;1187(3):289-95.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release. Gillick K and Crompton M, J Cell Sci. 2008 Mar 1;121(Pt 5):618-26. Epub 2008 Feb 5.
8. Increased rat brain cytochrome c correlates with degree of perinatal copper deficiency rather than apoptosis. Gybina AA and Prohaska JR, J Nutr. 2003 Nov;133(11):3361-8.
9. Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria. Inoki Y, etal., Biochem Biophys Res Commun. 2000 Oct 5;276(3):1210-6.
10. Extracellular cytochrome c as a biomarker for monitoring therapeutic efficacy and prognosis of non-small cell lung cancer patients. Javid J, etal., Tumour Biol. 2015 Jun;36(6):4253-60. doi: 10.1007/s13277-015-3062-6. Epub 2015 Jan 13.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Cytochrome C and caspase-9 expression in Huntington's disease. Kiechle T, etal., Neuromolecular Med. 2002;1(3):183-95.
13. Cytochrome c-induced cytosolic nicotinamide adenine dinucleotide oxidation, mitochondrial permeability transition, and apoptosis. La Piana G, etal., Arch Biochem Biophys 2003 Feb 15;410(2):201-11.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Morison IM, etal., Nat Genet. 2008 Apr;40(4):387-9. doi: 10.1038/ng.103. Epub 2008 Mar 16.
16. Clinical findings and biochemical and molecular analysis of four patients with holocarboxylase synthetase deficiency. Morrone A, etal., Am J Med Genet 2002 Jul 22;111(1):10-8.
17. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Mouria M, etal., Int J Cancer. 2002 Apr 10;98(5):761-9.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. [Cytochrome C content and mitochondrial activity in rat's cardiac and skeletal muscle cells in the course of 3-day gravitational unloading]. Ogneva IV, etal., Aviakosm Ekolog Med. 2014;48(6):23-9.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
22. Cytochrome c release from mitochondria proceeds by a two-step process. Ott M, etal., Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1259-63.
23. The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Pasdois P, etal., Biochem J. 2011 Jun 1;436(2):493-505. doi: 10.1042/BJ20101957.
24. Carbon monoxide inhalation: effect on heart cytochrome c in the neonatal and adult rat. Penney DG, etal., J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):395-406.
25. Exogenous phospholipids specifically affect transmembrane potential of brain mitochondria and cytochrome C release. Piccotti L, etal., J Biol Chem 2002 Apr 5;277(14):12075-81.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. Metabolism and function of mitochondrial cardiolipin. Ren M, etal., Prog Lipid Res. 2014 Jul;55:1-16. doi: 10.1016/j.plipres.2014.04.001. Epub 2014 Apr 24.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain. Russell JC, etal., J Neurochem. 2008 Aug;106(3):1357-70. Epub 2008 May 13.
34. Absence of CYCS mutations in a large Italian cohort of patients with inherited thrombocytopenias of unknown origin. Savoia A, etal., Platelets. 2009 Feb;20(1):72-3. doi: 10.1080/09537100802485129.
35. p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Song Y, etal., Toxicology. 2008 Nov 20;253(1-3):53-61. Epub 2008 Sep 4.
36. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Tan Z, etal., Cell Death Differ. 2007 Oct;14(10):1721-32. Epub 2007 Jun 15.
37. Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants. Virbasius JV and Scarpulla RC, J Biol Chem 1988 May 15;263(14):6791-6.
Additional References at PubMed
PMID:191069   PMID:6130852   PMID:6263917   PMID:8689682   PMID:10830166   PMID:12107093   PMID:12477932   PMID:14623868   PMID:14651853   PMID:14657025   PMID:14693685   PMID:15271982  
PMID:15475362   PMID:15489334   PMID:15907471   PMID:16103131   PMID:16469926   PMID:16757556   PMID:16854843   PMID:17634366   PMID:17899337   PMID:18070754   PMID:18418843   PMID:18614015  
PMID:18724894   PMID:19166515   PMID:19169378   PMID:19182904   PMID:19393246   PMID:20671748   PMID:20833797   PMID:21630459   PMID:21660956   PMID:22173498   PMID:22437740   PMID:22942730  
PMID:25512382   PMID:25634059   PMID:25848832   PMID:26271974   PMID:26316108   PMID:33710703   PMID:36755387  


Genomics

Comparative Map Data
Cycs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,982,667 - 80,984,767 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1862,552,743 - 62,553,968 (-)EnsemblGRCr8
GRCr8 Ensembl480,982,668 - 80,984,816 (-)EnsemblGRCr8
mRatBN7.2479,651,894 - 79,653,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,651,378 - 79,654,054 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1860,282,810 - 60,284,019 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,869,367 - 84,871,467 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,644,890 - 80,646,990 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0479,085,223 - 79,087,323 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0480,331,226 - 80,333,326 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl480,331,227 - 80,333,326 (-)Ensemblrn6Rnor6.0
Rnor_5.04145,002,156 - 145,004,256 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,825,878 - 78,827,978 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera474,558,589 - 74,560,689 (-)NCBICelera
RGSC_v3.1479,102,008 - 79,104,108 (-)NCBI
Cytogenetic Map4q24NCBI
CYCS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38725,118,656 - 25,125,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl725,118,656 - 25,125,266 (-)Ensemblhg38GRCh38
GRCh37725,158,275 - 25,164,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36725,124,800 - 25,131,480 (-)NCBIBuild 36Build 36hg18NCBI36
Celera725,146,921 - 25,154,374 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef725,044,828 - 25,051,539 (-)NCBIHuRef
CHM1_1725,160,181 - 25,166,894 (-)NCBICHM1_1
T2T-CHM13v2.0725,253,926 - 25,260,530 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2725,209,510 - 25,216,457 (-)NCBI
Cycs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39650,539,543 - 50,543,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl650,539,543 - 50,543,518 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38650,562,563 - 50,566,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl650,562,563 - 50,566,538 (-)Ensemblmm10GRCm38
MGSCv37650,512,562 - 50,516,473 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36650,492,149 - 50,496,060 (-)NCBIMGSCv36mm8
Celera651,079,647 - 51,083,558 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.32NCBI
LOC102023786
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541027,086,405 - 27,089,255 (-)Ensembl
ChiLan1.0NW_00495541027,086,405 - 27,089,255 (-)NCBIChiLan1.0ChiLan1.0
LOC100986481
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,973,124 - 29,977,324 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1778,297,856 - 78,302,051 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0725,784,900 - 25,791,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1725,396,013 - 25,398,549 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl725,396,013 - 25,398,549 (-)EnsemblpanPan2panpan1.1
CYCS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11438,579,446 - 38,581,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1438,579,446 - 38,581,983 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1438,129,129 - 38,131,665 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01438,516,027 - 38,518,562 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1438,513,097 - 38,518,530 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11438,628,462 - 38,630,996 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01438,321,370 - 38,323,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01438,663,988 - 38,666,523 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYCS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,169,866 - 47,173,866 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11847,169,921 - 47,172,212 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,036,068 - 52,038,366 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYCS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12133,251,825 - 33,253,298 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604271,404,460 - 71,406,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101718508
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247395,411,273 - 5,413,995 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247395,411,192 - 5,413,995 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116903823
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1690,515,515 - 90,517,245 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cycs
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:350
Count of miRNA genes:197
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000014058
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)48021363484338055Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
PMC195978P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,654,105 - 79,654,448 (+)MAPPERmRatBN7.2
Rnor_6.0480,333,438 - 80,333,780NCBIRnor6.0
Rnor_5.04145,004,368 - 145,004,710UniSTSRnor5.0
RGSC_v3.4478,828,090 - 78,828,432UniSTSRGSC3.4
Celera474,560,801 - 74,561,143UniSTS
Cytogenetic Map4q24UniSTS
RH139613  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 73 194 122 117 74 98 74 12 409 216 11 161 88 111 43 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014058   ⟹   ENSRNOP00000014058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl479,651,895 - 79,654,017 (-)Ensembl
Rnor_6.0 Ensembl480,331,227 - 80,333,326 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116426   ⟹   ENSRNOP00000077186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl479,651,378 - 79,654,054 (-)Ensembl
RefSeq Acc Id: NM_012839   ⟹   NP_036971
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,982,667 - 80,984,767 (-)NCBI
mRatBN7.2479,651,894 - 79,653,994 (-)NCBI
Rnor_6.0480,331,226 - 80,333,326 (-)NCBI
Rnor_5.04145,002,156 - 145,004,256 (-)NCBI
RGSC_v3.4478,825,878 - 78,827,978 (-)RGD
Celera474,558,589 - 74,560,689 (-)RGD
Sequence:
RefSeq Acc Id: NP_036971   ⟸   NM_012839
- UniProtKB: Q8C2S2 (UniProtKB/Swiss-Prot),   P00009 (UniProtKB/Swiss-Prot),   P62898 (UniProtKB/Swiss-Prot),   A6K0M2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014058   ⟸   ENSRNOT00000014058
Ensembl Acc Id: ENSRNOP00000077186   ⟸   ENSRNOT00000116426
Protein Domains
Cytochrome c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62898-F1-model_v2 AlphaFold P62898 1-105 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693043
Promoter ID:EPDNEW_R3568
Type:initiation region
Name:Cycs_1
Description:cytochrome c, somatic
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0480,333,363 - 80,333,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2451 AgrOrtholog
BioCyc Gene G2FUF-44889 BioCyc
Ensembl Genes ENSRNOG00000010452 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000065095 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014058 ENTREZGENE
  ENSRNOT00000014058.8 UniProtKB/Swiss-Prot
  ENSRNOT00000102631.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.760.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192255 IMAGE-MGC_LOAD
  IMAGE:7305562 IMAGE-MGC_LOAD
InterPro Cyt_c-like_dom UniProtKB/Swiss-Prot
  Cyt_c-like_dom_sf UniProtKB/Swiss-Prot
  Cyt_c_1A/1B UniProtKB/Swiss-Prot
KEGG Report rno:25309 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105497 IMAGE-MGC_LOAD
  MGC:93634 IMAGE-MGC_LOAD
NCBI Gene 25309 ENTREZGENE
PANTHER PTHR11961 UniProtKB/Swiss-Prot
Pfam Cytochrom_C UniProtKB/Swiss-Prot
PhenoGen Cycs PhenoGen
PRINTS CYTCHRMECIAB UniProtKB/Swiss-Prot
PROSITE CYTC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010452 RatGTEx
  ENSRNOG00000065095 RatGTEx
Superfamily-SCOP SSF46626 UniProtKB/Swiss-Prot
UniProt A6K0M2 ENTREZGENE, UniProtKB/TrEMBL
  CYC_RAT UniProtKB/Swiss-Prot
  P00009 ENTREZGENE
  P62898 ENTREZGENE
  Q8C2S2 ENTREZGENE
UniProt Secondary P00009 UniProtKB/Swiss-Prot
  Q8C2S2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cycs  cytochrome c, somatic      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with cardiolipin 70241
gene_regulation release from brain mitochondria is inhibited by enrichment with cardiolipin 727631