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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2451
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of CYCS proteinPMID:37451666
Cycsmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS protein; Cadmium Chloride inhibits the reaction [TNF protein affects the localization of CYCS protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS protein]; SIRT1 promotes the reaction [Cadmium Chloride results in increased expression of CYCS protein]PMID:16263807 PMID:34767868 PMID:37451666
Cycsaffects localizationISOCycs (Mus musculus)6480464CTDCadmium Chloride affects the localization of CYCS proteinPMID:21908765
Cycsaffects localizationISOCYCS (Homo sapiens)6480464CTDCadmium Chloride affects the localization of CYCS proteinPMID:24291162
Cycsincreases expressionISOCYCS (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CYCS proteinPMID:28422390
Cycsmultiple interactionsISOCycs (Mus musculus)6480464CTDPhenylbutyrates inhibits the reaction [Cadmium Chloride affects the localization of CYCS protein]PMID:21908765
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTDnaringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein]PMID:28422390
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