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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2451
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsaffects localizationEXP 6480464CTDNicotine affects the localization of CYCS proteinPMID:15985439
Cycsincreases expressionEXP 6480464CTDNicotine results in increased expression of CYCS proteinPMID:29972271
Cycsincreases secretionEXP 6480464CTDNicotine results in increased secretion of CYCS proteinPMID:18203686
Cycsmultiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein]PMID:15985439 PMID:29972271
Cycsdecreases secretionISOCYCS (Homo sapiens)6480464CTDNicotine results in decreased secretion of CYCS proteinPMID:11701223
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTDNicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]PMID:15985439
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