GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cycs | decreases expression | EXP | | 6480464 | CTD | Copper results in decreased expression of CYCS mRNA | PMID:22465980 | Cycs | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of CYCS protein | PMID:30556269 | Cycs | multiple interactions | EXP | | 6480464 | CTD | [Copper binds to neocuproine] which affects the localization of CYCS protein; [Copper co-treated with pyrrolidine dithiocarbamic acid] affects the localization of CYCS protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] affects the localization of CYCS protein]; bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which affects the localization of CYCS protein] | PMID:18056745 PMID:22085843 | Cycs | decreases expression | ISO | CYCS (Homo sapiens) | 6480464 | CTD | Copper deficiency results in decreased expression of CYCS protein | PMID:24708542 | Cycs | multiple interactions | ISO | CYCS (Homo sapiens) | 6480464 | CTD | [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; [Chelating Agents binds to Copper] which results in increased expression of CYCS mRNA; [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein; [Ditiocarb binds to Copper] which affects the localization of CYCS protein; [pyrrolidine dithiocarbamic acid binds to Copper] which affects the localization of CYCS protein; [Thiosemicarbazones binds to Copper] which results in increased expression of CYCS protein | PMID:17327230 PMID:18671963 PMID:20931265 PMID:22951949 PMID:30911355 | | ||||||||||||||||||||||
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