Arrb1 (arrestin, beta 1) - Rat Genome Database

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Gene: Arrb1 (arrestin, beta 1) Rattus norvegicus
Analyze
Symbol: Arrb1
Name: arrestin, beta 1
RGD ID: 2156
Description: Enables several functions, including AP-2 adaptor complex binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including follicle-stimulating hormone signaling pathway; regulation of ERK1 and ERK2 cascade; and regulation of primary metabolic process. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density. Used to study congestive heart failure. Biomarker of colitis. Orthologous to human ARRB1 (arrestin beta 1); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arrestin beta-1; BARRES; beta-arrestin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp138
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,249,654 - 163,321,711 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1163,250,157 - 163,340,859 (+)EnsemblGRCr8
mRatBN7.21153,837,964 - 153,912,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,838,078 - 153,904,061 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1161,833,965 - 161,899,728 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,014,116 - 169,079,853 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,887,644 - 161,953,403 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,502,099 - 164,573,947 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)Ensemblrn6Rnor6.0
Rnor_5.01170,705,795 - 170,777,617 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,871,564 - 156,937,540 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,924,752 - 151,989,492 (+)NCBICelera
RGSC_v3.11156,949,969 - 157,015,946 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
alprenolol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carteolol  (ISO)
carvedilol  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
ibuprofen  (ISO)
isoprenaline  (ISO)
leukotriene D4  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
mesalamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
metoprolol  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (TAS)
cell surface receptor signaling pathway  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (IDA,ISO)
endocytosis  (IDA,IEA)
follicle-stimulating hormone signaling pathway  (IDA,IEA)
G protein-coupled receptor internalization  (IBA,ISO)
G protein-coupled receptor signaling pathway  (IDA)
intracellular glucose homeostasis  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of GTPase activity  (IDA)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of Notch signaling pathway  (IBA,ISO,ISS)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein ubiquitination  (ISO)
negative regulation of signal transduction  (IEA)
phototransduction  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of MAPK cascade  (IDA)
positive regulation of protein phosphorylation  (IMP,ISO,ISS)
positive regulation of protein ubiquitination  (IMP)
positive regulation of receptor internalization  (ISO,ISS)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein transport  (IEA)
protein ubiquitination  (ISO)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (IDA)
regulation of G protein-coupled receptor signaling pathway  (IDA,IEA,ISO,TAS)
regulation of inositol trisphosphate biosynthetic process  (IMP)
regulation of protein ubiquitination  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
response to morphine  (IEA,IEP)
response to xenobiotic stimulus  (IEP)
sensory perception  (IBA,IEA)
sensory perception of touch  (TAS)
signal transduction  (IEA)
stress fiber assembly  (ISO)
ubiquitin-dependent protein catabolic process  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. Ahn S, etal., J Biol Chem. 2009 Mar 27;284(13):8855-65. Epub 2009 Jan 26.
2. Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. Attramadal H, etal., J Biol Chem 1992 Sep 5;267(25):17882-90.
3. Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. Avissar S, etal., Am J Psychiatry. 2004 Nov;161(11):2066-72.
4. Bidirectional allosteric interactions between cannabinoid receptor 1 (CB1) and dopamine receptor 2 long (D2L) heterotetramers. Bagher AM, etal., Eur J Pharmacol. 2017 Oct 15;813:66-83. doi: 10.1016/j.ejphar.2017.07.034. Epub 2017 Jul 19.
5. Beta-arrestins: multifunctional cellular mediators. Barki-Harrington L and Rockman HA, Physiology (Bethesda). 2008 Feb;23:17-22.
6. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
7. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Chen W, etal., Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14889-94. Epub 2001 Dec 11.
8. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Dalle S, etal., Mol Cell Biol 2002 Sep;22(17):6272-85.
9. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. DeFea KA, etal., J Cell Biol. 2000 Mar 20;148(6):1267-81.
10. Gender related alterations of beta-adrenoceptor mechanisms in heart failure due to arteriovenous fistula. Dent MR, etal., J Cell Physiol. 2011 Oct 20. doi: 10.1002/jcp.23058.
11. 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. Dominguez R, etal., J Neurosci. 2009 Apr 1;29(13):4228-38.
12. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
13. Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine. Fan XL, etal., Neuroscience. 2003;117(2):383-9. doi: 10.1016/s0306-4522(02)00930-2.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Antidepressants elevate GDNF expression and release from C(6) glioma cells in a beta-arrestin1-dependent, CREB interactive pathway. Golan M, etal., Int J Neuropsychopharmacol. 2011 Nov;14(10):1289-300. doi: 10.1017/S1461145710001550. Epub 2011 Jan 12.
17. A stress response pathway regulates DNA damage through ß2-adrenoreceptors and ß-arrestin-1. Hara MR, etal., Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.
18. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. Hauger RL, etal., CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79.
19. Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases. Iacovelli L, etal., J Biol Chem 2003 Apr 4;278(14):12433-42. Epub 2003 Jan 07.
20. The induction of thioredoxin-1 by epinephrine withdraws stress via interaction with ß-arrestin-1. Jia JJ, etal., Cell Cycle. 2014;13(19):3121-31. doi: 10.4161/15384101.2014.949214.
21. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Kang J, etal., Cell. 2005 Dec 2;123(5):833-47.
22. Differential regulation of endosomal GPCR/ß-arrestin complexes and trafficking by MAPK. Khoury E, etal., J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11.
23. Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. Kim J, etal., J Biol Chem. 2009 May 1;284(18):11953-62. Epub 2009 Mar 2.
24. Presence of beta-arrestin-1 immunoreactivity in the cutaneous nerve fibers of rat glabrous skin. Komori N, etal., Brain Res 2003 Oct 24;988(1-2):121-9.
25. [Pathogenetic mechanism of beta-arrestin1 in experimental colitis of rats and intervention effects of oxymatrine]. Liao Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Oct;30(10):1067-72.
26. Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain. Lombardi MS, etal., Stroke 2004 Apr;35(4):981-6. Epub 2004 Mar 11.
27. Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. Lymperopoulos A, etal., J Am Coll Cardiol. 2011 Jan 18;57(3):356-65.
28. An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo. Lymperopoulos A, etal., Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5825-30. Epub 2009 Mar 16.
29. Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation. Maharana J, etal., Mol Cell. 2023 Jun 15;83(12):2091-2107.e7. doi: 10.1016/j.molcel.2023.04.025. Epub 2023 May 19.
30. Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors. Maharana J, etal., Science. 2024 Jan 5;383(6678):101-108. doi: 10.1126/science.adj3347. Epub 2024 Jan 4.
31. G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. Marion S, etal., J Endocrinol. 2006 Aug;190(2):341-50.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. Mishra SK, etal., J Biol Chem. 2005 May 13;280(19):19270-80. Epub 2005 Feb 22.
34. G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Morris GE, etal., Cardiovasc Res. 2011 Jan 1;89(1):193-203. Epub 2010 Aug 12.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. Nobles KN, etal., J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18.
37. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Perry SJ, etal., Science 2002 Oct 25;298(5594):834-6.
38. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. ¿-arrestin 1 (ARRDC1) and ß-arrestins cooperate to mediate Notch degradation in mammals. Puca L, etal., J Cell Sci. 2013 Oct 1;126(Pt 19):4457-68. doi: 10.1242/jcs.130500. Epub 2013 Jul 25.
41. GOA pipeline RGD automated data pipeline
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Schmidlin F, etal., Am J Physiol Cell Physiol 2003 Oct;285(4):C945-58.
44. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
45. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. Shukla AK, etal., J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22.
46. Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Shukla AK, etal., Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.
47. Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. Stanasila L, etal., Mol Pharmacol. 2008 Sep;74(3):562-73. Epub 2008 Jun 3.
48. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
49. Biased agonism of the calcium-sensing receptor. Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
50. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
51. Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. Vinge LE, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2490-9.
52. The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony. Wang QT, etal., J Ethnopharmacol. 2011 Jan 27;133(2):511-6. Epub 2010 Oct 19.
53. Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Wang WY, etal., Neuroscience. 2016 Jan 28;313:199-212. doi: 10.1016/j.neuroscience.2015.11.038. Epub 2015 Nov 24.
54. Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, etal., Immunobiology. 2011 Jul;216(7):854-61. doi: 10.1016/j.imbio.2010.11.005. Epub 2010 Dec 3.
55. PAR-1 activation rescues astrocytes through the PI3K/Akt signaling pathway from chemically induced apoptosis that is exacerbated by gene silencing of ß-arrestin 1. Zhu Z and Reiser G, Neurochem Int. 2014 Feb;67:46-56. doi: 10.1016/j.neuint.2013.12.007. Epub 2013 Dec 27.
56. Role of ssarrestins in bradykinin B2 receptor-mediated signalling. Zimmerman B, etal., Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8.
57. Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. Zoudilova M, etal., J Biol Chem. 2007 Jul 13;282(28):20634-46. Epub 2007 May 11.
Additional References at PubMed
PMID:9400383   PMID:10196135   PMID:10521508   PMID:10644702   PMID:10823817   PMID:11171997   PMID:11278883   PMID:11853756   PMID:12582207   PMID:12821670   PMID:15308653   PMID:15456867  
PMID:15561704   PMID:15611106   PMID:15878855   PMID:16378096   PMID:16641100   PMID:17456469   PMID:18276584   PMID:18445652   PMID:18505723   PMID:19915011   PMID:21323643   PMID:21466165  
PMID:22457824   PMID:23174211   PMID:23353685   PMID:23633677   PMID:23690069   PMID:25081544   PMID:25081814   PMID:25480575   PMID:25542150   PMID:25803606   PMID:26399643   PMID:26531813  
PMID:29476059   PMID:30347436   PMID:31269046   PMID:31506606   PMID:31948726   PMID:38152023   PMID:38838859  


Genomics

Comparative Map Data
Arrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,249,654 - 163,321,711 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1163,250,157 - 163,340,859 (+)EnsemblGRCr8
mRatBN7.21153,837,964 - 153,912,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,838,078 - 153,904,061 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1161,833,965 - 161,899,728 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,014,116 - 169,079,853 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,887,644 - 161,953,403 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,502,099 - 164,573,947 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)Ensemblrn6Rnor6.0
Rnor_5.01170,705,795 - 170,777,617 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,871,564 - 156,937,540 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,924,752 - 151,989,492 (+)NCBICelera
RGSC_v3.11156,949,969 - 157,015,946 (+)NCBI
Cytogenetic Map1q32NCBI
ARRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,260,122 - 75,351,661 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,260,122 - 75,351,791 (-)Ensemblhg38GRCh38
GRCh371174,971,166 - 75,062,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,654,130 - 74,740,521 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341174,654,129 - 74,740,521NCBI
Celera1172,283,036 - 72,369,427 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,268,798 - 71,360,118 (-)NCBIHuRef
CHM1_11174,854,770 - 74,946,464 (-)NCBICHM1_1
T2T-CHM13v2.01175,189,729 - 75,281,255 (-)NCBIT2T-CHM13v2.0
Arrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,184,356 - 99,255,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,184,673 - 99,255,978 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38799,535,147 - 99,606,772 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,535,466 - 99,606,771 (+)Ensemblmm10GRCm38
MGSCv377106,683,996 - 106,755,281 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36799,409,569 - 99,480,854 (+)NCBIMGSCv36mm8
Celera799,859,615 - 99,932,041 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.09NCBI
Arrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,478,843 - 16,562,135 (+)Ensembl
ChiLan1.0NW_00495541416,478,843 - 16,568,050 (+)NCBIChiLan1.0ChiLan1.0
ARRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,190,602 - 76,281,939 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,233,278 - 77,324,616 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,319,935 - 70,411,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11173,624,254 - 73,670,495 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1173,630,276 - 73,654,155 (-)EnsemblpanPan2panpan1.1
ARRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,261,020 - 23,304,448 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,235,711 - 23,297,786 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2122,990,721 - 23,068,006 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02123,428,040 - 23,505,333 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,428,093 - 23,507,491 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,226,359 - 23,303,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,422,622 - 23,499,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,340,581 - 23,417,904 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,490,018 - 62,573,146 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,094,893 - 4,172,755 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,089,621 - 4,172,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,516,947 - 9,597,976 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.199,516,944 - 9,597,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,659,892 - 10,767,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,489,358 - 66,580,167 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,490,102 - 66,580,154 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604359,230,347 - 59,326,828 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,750,156 - 1,823,309 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248171,750,448 - 1,828,399 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arrb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1297,846,667 - 97,869,864 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arrb1
566 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:77
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000043554
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043554   ⟹   ENSRNOP00000046069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,294,189 - 163,316,194 (+)Ensembl
mRatBN7.2 Ensembl1153,882,186 - 153,904,061 (+)Ensembl
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095649   ⟹   ENSRNOP00000081144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,294,186 - 163,315,037 (+)Ensembl
mRatBN7.2 Ensembl1153,870,540 - 153,904,061 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118341   ⟹   ENSRNOP00000095275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,250,243 - 163,323,478 (+)Ensembl
mRatBN7.2 Ensembl1153,838,078 - 153,904,061 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125345   ⟹   ENSRNOP00000110444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,294,189 - 163,340,859 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143451   ⟹   ENSRNOP00000112649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,285,484 - 163,340,859 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151116   ⟹   ENSRNOP00000105900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,250,157 - 163,340,859 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153802   ⟹   ENSRNOP00000102308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,283,009 - 163,340,859 (+)Ensembl
RefSeq Acc Id: NM_012910   ⟹   NP_037042
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,216 - 163,316,194 (+)NCBI
mRatBN7.21153,838,080 - 153,904,061 (+)NCBI
Rnor_6.01164,502,452 - 164,568,430 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
RGSC_v3.41156,871,564 - 156,937,540 (+)RGD
Celera1151,924,752 - 151,989,492 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229735   ⟹   XP_006229797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,140 - 163,321,711 (+)NCBI
mRatBN7.21153,838,000 - 153,912,111 (+)NCBI
Rnor_6.01164,534,778 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229736   ⟹   XP_006229798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,144 - 163,321,711 (+)NCBI
mRatBN7.21153,870,838 - 153,912,111 (+)NCBI
Rnor_6.01164,534,779 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229737   ⟹   XP_006229799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,143 - 163,321,711 (+)NCBI
mRatBN7.21153,870,838 - 153,912,111 (+)NCBI
Rnor_6.01164,534,779 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229738   ⟹   XP_006229800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,133 - 163,316,012 (+)NCBI
mRatBN7.21153,838,000 - 153,903,879 (+)NCBI
Rnor_6.01164,534,776 - 164,568,248 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229739   ⟹   XP_006229801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,292,596 - 163,321,711 (+)NCBI
mRatBN7.21153,881,564 - 153,912,111 (+)NCBI
Rnor_6.01164,545,993 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229740   ⟹   XP_006229802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,249,654 - 163,321,711 (+)NCBI
mRatBN7.21153,837,964 - 153,912,111 (+)NCBI
Rnor_6.01164,502,099 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229741   ⟹   XP_006229803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,283,543 - 163,321,711 (+)NCBI
mRatBN7.21153,871,427 - 153,912,111 (+)NCBI
Rnor_6.01164,537,698 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101614   ⟹   XP_038957542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,141 - 163,321,711 (+)NCBI
mRatBN7.21153,838,000 - 153,912,111 (+)NCBI
RefSeq Acc Id: XM_039101664   ⟹   XP_038957592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,133 - 163,316,012 (+)NCBI
mRatBN7.21153,838,000 - 153,903,879 (+)NCBI
RefSeq Acc Id: XM_039101685   ⟹   XP_038957613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,133 - 163,306,292 (+)NCBI
mRatBN7.21153,838,000 - 153,894,158 (+)NCBI
RefSeq Acc Id: XM_063281752   ⟹   XP_063137822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,250,141 - 163,316,012 (+)NCBI
RefSeq Acc Id: XM_063281756   ⟹   XP_063137826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,292,596 - 163,321,711 (+)NCBI
RefSeq Acc Id: XM_063281766   ⟹   XP_063137836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,292,596 - 163,321,711 (+)NCBI
RefSeq Acc Id: XM_063281770   ⟹   XP_063137840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,249,654 - 163,321,711 (+)NCBI
RefSeq Acc Id: XM_063281772   ⟹   XP_063137842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,249,657 - 163,321,711 (+)NCBI
RefSeq Acc Id: XM_063281775   ⟹   XP_063137845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,283,559 - 163,321,711 (+)NCBI
RefSeq Acc Id: XM_063281776   ⟹   XP_063137846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,249,655 - 163,316,012 (+)NCBI
RefSeq Acc Id: NP_037042   ⟸   NM_012910
- UniProtKB: P29066 (UniProtKB/Swiss-Prot),   A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229802   ⟸   XM_006229740
- Peptide Label: isoform X10
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229800   ⟸   XM_006229738
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229797   ⟸   XM_006229735
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229798   ⟸   XM_006229736
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229799   ⟸   XM_006229737
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G7K6 (UniProtKB/TrEMBL),   A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229803   ⟸   XM_006229741
- Peptide Label: isoform X11
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229801   ⟸   XM_006229739
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046069   ⟸   ENSRNOT00000043554
RefSeq Acc Id: XP_038957542   ⟸   XM_039101614
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957592   ⟸   XM_039101664
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957613   ⟸   XM_039101685
- Peptide Label: isoform X17
Ensembl Acc Id: ENSRNOP00000095275   ⟸   ENSRNOT00000118341
Ensembl Acc Id: ENSRNOP00000081144   ⟸   ENSRNOT00000095649
RefSeq Acc Id: XP_063137840   ⟸   XM_063281770
- Peptide Label: isoform X13
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137846   ⟸   XM_063281776
- Peptide Label: isoform X16
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137842   ⟸   XM_063281772
- Peptide Label: isoform X14
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137822   ⟸   XM_063281752
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137845   ⟸   XM_063281775
- Peptide Label: isoform X15
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137826   ⟸   XM_063281756
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QMJ8 (UniProtKB/TrEMBL),   A0A8I6GL31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137836   ⟸   XM_063281766
- Peptide Label: isoform X12
- UniProtKB: A0A8I6GL31 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110444   ⟸   ENSRNOT00000125345
Ensembl Acc Id: ENSRNOP00000105900   ⟸   ENSRNOT00000151116
Ensembl Acc Id: ENSRNOP00000102308   ⟸   ENSRNOT00000153802
Ensembl Acc Id: ENSRNOP00000112649   ⟸   ENSRNOT00000143451
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29066-F1-model_v2 AlphaFold P29066 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690229
Promoter ID:EPDNEW_R753
Type:initiation region
Name:Arrb1_1
Description:arrestin, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,502,430 - 164,502,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2156 AgrOrtholog
BioCyc Gene G2FUF-58383 BioCyc
Ensembl Genes ENSRNOG00000030404 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000043554 ENTREZGENE
  ENSRNOT00000118341 ENTREZGENE
  ENSRNOT00000125345 ENTREZGENE
  ENSRNOT00000143451 ENTREZGENE
  ENSRNOT00000153802 ENTREZGENE
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot
  2.60.40.840 UniProtKB/Swiss-Prot
InterPro Arrestin UniProtKB/Swiss-Prot
  Arrestin-like_N UniProtKB/Swiss-Prot
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot
  Arrestin_CS UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:25387 UniProtKB/Swiss-Prot
NCBI Gene 25387 ENTREZGENE
PANTHER BETA-ARRESTIN-1 UniProtKB/Swiss-Prot
  PTHR11792 UniProtKB/Swiss-Prot
Pfam Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
PhenoGen Arrb1 PhenoGen
PRINTS ARRESTIN UniProtKB/Swiss-Prot
PROSITE ARRESTINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030404 RatGTEx
SMART Arrestin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
TIGR TC228510
UniProt A0A8I6G7K6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL31 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QMJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L734_RAT UniProtKB/TrEMBL
  A0ABK0LMM4_RAT UniProtKB/TrEMBL
  A0ABK0M4Z5_RAT UniProtKB/TrEMBL
  A0ABK0M5L6_RAT UniProtKB/TrEMBL
  A6I6J0_RAT UniProtKB/TrEMBL
  A6I6J1_RAT UniProtKB/TrEMBL
  A6I6J2_RAT UniProtKB/TrEMBL
  ARRB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Arrb1  Arrestin, beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to postsynaptic sites 631708
gene_expression expressed in neuronal tissues and spleen 631708
gene_expression expressed in endothelial cells 628504
gene_process inhibited beta 2AR function 631708
gene_process may work with beta ARK to regulate G protein-coupled neurotransmitter receptors 631797
gene_process mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs) 631708
gene_process mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs) 631797
gene_process mediates desensitization and downregulation of G protein-coupled receptors (GPCRs) 628504
gene_regulation insulin induces ubiquitination and proteosomal degradation 631797
gene_regulation mRNA level increases in postinfarction (heart) failure 628504