Myd88 (MYD88, innate immune signal transduction adaptor) - Rat Genome Database

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Gene: Myd88 (MYD88, innate immune signal transduction adaptor) Rattus norvegicus
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Symbol: Myd88
Name: MYD88, innate immune signal transduction adaptor
RGD ID: 735043
Description: Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in several processes, including JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Part of protein-containing complex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myeloid differentiation primary response 88; myeloid differentiation primary response gene 88; myeloid differentiation primary response protein MyD88
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,952,161 - 127,956,230 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,952,161 - 127,956,230 (-)EnsemblGRCr8
mRatBN7.28119,074,439 - 119,078,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,074,437 - 119,079,415 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,656,479 - 124,660,550 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,855,496 - 122,859,567 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,689,025 - 120,693,095 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)Ensemblrn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,225,640 - 118,229,709 (-)NCBICelera
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
anemia  (ISO)
anogenital venereal wart  (ISO)
asthma  (ISO)
Bacterial Keratitis  (ISO)
Binge Drinking  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cachexia  (ISO)
Carcinoma, Lewis Lung  (ISO)
central nervous system lymphoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Colitis-Associated Neoplasms  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Polyps  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
Colorectal Cancer 10  (ISO)
colorectal carcinoma  (ISO)
Coronavirus infectious disease  (ISS)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
Eosinophilia  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
extrahepatic cholestasis  (ISO)
follicular lymphoma  (ISO)
gastroenteritis  (ISO)
genetic disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (IEP,ISO)
hypertension  (ISO)
Immunodeficiency 68  (ISO)
Inflammation  (ISO)
Intestinal Polyps  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoplasmacytic lymphoma  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
monoclonal gammopathy of uncertain significance  (ISS)
Myocardial Reperfusion Injury  (IDA)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
pneumonia  (ISO)
pulmonary eosinophilia  (ISO)
Reperfusion Injury  (ISO)
severe acute respiratory syndrome  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
testicular lymphoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-mercaptopropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
5-fluorouracil  (EXP)
6-Methoxyflavone  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
afzelechin  (EXP)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP)
aldicarb  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP,ISO)
Alpinetin  (ISO)
Alternaramide  (ISO)
Ammothamnine  (EXP)
ampicillin  (ISO)
anethole  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
atorvastatin calcium  (EXP)
ATP  (ISO)
baicalin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Bergenin  (ISO)
beta-D-glucan  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boldenone  (EXP)
bortezomib  (ISO)
bosentan  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium telluride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
cefoxitin  (ISO)
chaetoglobosin A  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chrysin  (ISO)
cirsilineol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
crocin-1  (EXP)
CU-CPT22  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-penicillamine  (ISO)
DAPT  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
desloratadine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
epoxiconazole  (ISO)
eritoran  (ISO)
erlotinib hydrochloride  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
euxanthone  (ISO)
Evodiamine  (ISO)
famotidine  (ISO)
Fast green FCF  (ISO)
fenthion  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
fisetin  (ISO)
flavokawain B  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fosaprepitant  (ISO)
FR900359  (ISO)
fructose  (ISO)
galactose  (EXP,ISO)
Gastrodin  (EXP)
Genipin  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
Ginkgolide A  (ISO)
glucose  (EXP)
graphene oxide  (ISO)
GSK-J4  (ISO)
Harpagide  (ISO)
heme b  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
icosanoid  (ISO)
immunological adjuvant  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
Kukoamine B  (ISO)
lactulose  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
metam  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
metronidazole  (ISO)
monocrotaline  (ISO)
Morroniside  (ISO)
motexafin gadolinium  (ISO)
muramyl dipeptide  (ISO)
myrtenol  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrates  (ISO)
Nonylphenol  (EXP)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
peptidoglycan  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
robinin  (EXP)
rosmarinic acid  (EXP)
rotenone  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
saxagliptin  (EXP)
scoparone  (ISO)
scopoletin  (EXP)
scutellarin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium propionate  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (EXP)
Timosaponin b ii  (ISO)
titanium atom  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
trans-anethole  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc nitrate  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA stabilization  (IEA,ISO)
apoptotic process  (IEA,ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
chromatin organization  (IEA,ISO)
chromatin remodeling  (IEA)
cytokine-mediated signaling pathway  (IEA,IMP)
defense response to bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (IBA,IEA,ISO,ISS)
defense response to protozoan  (ISO)
defense response to virus  (IEA,ISO,ISS)
establishment of endothelial intestinal barrier  (ISO)
gene expression  (IEA,ISO)
immune system process  (IEA)
immunoglobulin mediated immune response  (ISO)
induced systemic resistance  (ISO)
inflammatory response  (IEA,ISO)
innate immune response  (IBA,IEA)
interleukin-1-mediated signaling pathway  (IEA,ISO)
interleukin-33-mediated signaling pathway  (IEA,ISO)
JNK cascade  (IEA,IMP)
lipopolysaccharide-mediated signaling pathway  (ISO)
microglia differentiation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IEA,ISO)
neurogenesis  (ISO)
neutrophil activation involved in immune response  (ISO)
neutrophil-mediated killing of bacterium  (ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (ISO)
phagocytosis  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO,TAS)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-17 production  (IEA,ISO)
positive regulation of interleukin-23 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (IEA,ISO)
regulation of cell population proliferation  (ISO)
regulation of chemokine (C-X-C motif) ligand 1 production  (ISO)
regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
regulation of gene expression  (ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of interleukin-6 production  (ISO)
regulation of neutrophil migration  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to amine  (IEP)
response to amino acid  (IEP)
response to ethanol  (IEP)
response to interleukin-1  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to molecule of fungal origin  (ISO)
response to peptidoglycan  (ISO)
response to virus  (ISO)
signal transduction  (IEA)
skin development  (IEA,ISO)
Toll signaling pathway  (IBA,IDA)
toll-like receptor 4 signaling pathway  (IBA,IEA,ISO)
toll-like receptor 5 signaling pathway  (IEA,ISO)
toll-like receptor 8 signaling pathway  (IEA,ISO,ISS)
toll-like receptor TLR6:TLR2 signaling pathway  (IEA,ISO)
type I interferon-mediated signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Anderson BJ, etal., Crit Care. 2019 Dec 9;23(1):400. doi: 10.1186/s13054-019-2684-2.
2. Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Banerjee A, etal., Infect Immun. 2014 Jan;82(1):356-63. doi: 10.1128/IAI.01344-13. Epub 2013 Oct 28.
3. The Toll-Like Receptor/MyD88/XBP1 Signaling Axis Mediates Skeletal Muscle Wasting during Cancer Cachexia. Bohnert KR, etal., Mol Cell Biol. 2019 Jul 16;39(15). pii: MCB.00184-19. doi: 10.1128/MCB.00184-19. Print 2019 Aug 1.
4. Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 and CD79B mutations. Cao XX, etal., Ann Hematol. 2017 Nov;96(11):1867-1871. doi: 10.1007/s00277-017-3094-7. Epub 2017 Aug 12.
5. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling. Chandrasekar B, etal., J Biol Chem. 2005 Jul 15;280(28):26263-77. Epub 2005 May 11.
6. Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. Chang CW, etal., Int J Mol Sci. 2020 Jan 8;21(2). pii: ijms21020386. doi: 10.3390/ijms21020386.
7. Morphologic Patterns and the Correlation With MYD88 L265P, CD79B Mutations in Primary Adrenal Diffuse Large B-Cell Lymphoma. Chen Z, etal., Am J Surg Pathol. 2020 Apr;44(4):444-455. doi: 10.1097/PAS.0000000000001386.
8. Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. Coleman OI, etal., Gastroenterology. 2018 Nov;155(5):1539-1552.e12. doi: 10.1053/j.gastro.2018.07.028. Epub 2018 Jul 29.
9. Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells. Deng Y, etal., Genet Mol Res. 2016 Mar 4;15(1):15016826. doi: 10.4238/gmr.15016826.
10. Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway. Ding YF, etal., Front Pharmacol. 2019 Apr 24;10:389. doi: 10.3389/fphar.2019.00389. eCollection 2019.
11. Growth, metastasis, and expression of CCL2 and CCL5 by murine mammary carcinomas are dependent upon Myd88. Egunsola AT, etal., Cell Immunol. 2012;272(2):220-9. doi: 10.1016/j.cellimm.2011.10.008. Epub 2011 Oct 25.
12. Mutational frequencies of CD79B and MYD88 vary greatly between primary testicular DLBCL and gastrointestinal DLBCL. Frick M, etal., Leuk Lymphoma. 2018 May;59(5):1260-1263. doi: 10.1080/10428194.2017.1370546. Epub 2017 Sep 3.
13. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Grommes C, etal., Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15.
16. Glycosaminoglycans are important mediators of neutrophilic inflammation in vivo. Gschwandtner M, etal., Cytokine. 2017 Mar;91:65-73. doi: 10.1016/j.cyto.2016.12.008. Epub 2016 Dec 21.
17. Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity. Hartman ZC, etal., Cancer Res. 2010 Sep 15;70(18):7209-20. doi: 10.1158/0008-5472.CAN-10-0905. Epub 2010 Sep 7.
18. Adamantane-linked isothiourea derivatives suppress the growth of experimental hepatocellular carcinoma via inhibition of TLR4-MyD88-NF-κB signaling. Hassan HM, etal., Am J Cancer Res. 2021 Feb 1;11(2):350-369. eCollection 2021.
19. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. Hazeki K, etal., Eur J Immunol 2003 Mar;33(3):740-7.
20. Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. He M, etal., Toxicol Appl Pharmacol. 2016 Apr 1;296:61-72. doi: 10.1016/j.taap.2016.02.011. Epub 2016 Feb 13.
21. Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy. Holtorf A, etal., Oncoimmunology. 2018 Jun 11;7(8):e1466770. doi: 10.1080/2162402X.2018.1466770. eCollection 2018.
22. Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells. Hong EH, etal., Int J Cancer. 2013 Jun 15;132(12):2839-48. doi: 10.1002/ijc.27974. Epub 2012 Dec 19.
23. Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis. Hu Q, etal., J Int Med Res. 2020 May;48(5):300060520917877. doi: 10.1177/0300060520917877.
24. Enhanced myeloid differentiation factor 88 promotes tumor metastasis via induction of epithelial-mesenchymal transition in human hepatocellular carcinoma. Jia RJ, etal., Cell Death Dis. 2014 Mar 6;5:e1103. doi: 10.1038/cddis.2014.71.
25. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Jin C, etal., Cell. 2019 Feb 21;176(5):998-1013.e16. doi: 10.1016/j.cell.2018.12.040. Epub 2019 Jan 31.
26. Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. Kajino-Sakamoto R, etal., Oncogene. 2021 Jan;40(2):408-420. doi: 10.1038/s41388-020-01541-3. Epub 2020 Nov 12.
27. Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis. Kennedy CL, etal., Oncogene. 2014 May 8;33(19):2540-6. doi: 10.1038/onc.2013.205. Epub 2013 Jun 3.
28. Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition. Kim SJ and Lee SM, Toxicol Appl Pharmacol. 2012 Jan 1;258(1):43-50. doi: 10.1016/j.taap.2011.10.005. Epub 2011 Oct 14.
29. Clinical and pathological significance of myeloid differentiation factor 88 expression in human hepatocellular carcinoma tissues. Kinowaki K, etal., Pathol Int. 2017 May;67(5):256-263. doi: 10.1111/pin.12529. Epub 2017 Apr 3.
30. Functional TLR5 genetic variants affect human colorectal cancer survival. Klimosch SN, etal., Cancer Res. 2013 Dec 15;73(24):7232-42. doi: 10.1158/0008-5472.CAN-13-1746. Epub 2013 Oct 23.
31. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. Koliaraki V, etal., Cell Rep. 2019 Jan 15;26(3):536-545.e4. doi: 10.1016/j.celrep.2018.12.072.
32. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
33. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
34. Genetic polymorphism of CCL2-2518, CXCL10-201, IL8+781 and susceptibility to severity of Enterovirus-71 infection in a Chinese population. Li JA, etal., Inflamm Res. 2014 Jul;63(7):549-56. doi: 10.1007/s00011-014-0724-6. Epub 2014 Mar 9.
35. Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer. Li WL, etal., Gene. 2014 Aug 10;546(2):263-70. doi: 10.1016/j.gene.2014.05.070. Epub 2014 Jun 2.
36. Implication of myeloid differentiation factor 88 inhibitor TJ-M2010-5 for therapeutic intervention of hepatocellular carcinoma. Liu J, etal., Hepatol Res. 2019 Oct;49(10):1182-1194. doi: 10.1111/hepr.13359. Epub 2019 May 9.
37. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. Lozano-Pope I, etal., BMC Cancer. 2017 Feb 15;17(1):133. doi: 10.1186/s12885-017-3114-y.
38. Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment. Maeda Y, etal., Cancer Prev Res (Phila). 2016 Mar;9(3):253-63. doi: 10.1158/1940-6207.CAPR-15-0315. Epub 2016 Feb 17.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
41. MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis. Mohs A, etal., Carcinogenesis. 2020 Apr 22;41(2):171-181. doi: 10.1093/carcin/bgy173.
42. Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians. Natividad A, etal., BMC Med Genet. 2009 Dec 16;10:138. doi: 10.1186/1471-2350-10-138.
43. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Naugler WE, etal., Science. 2007 Jul 6;317(5834):121-4. doi: 10.1126/science.1140485.
44. S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Oliva J, etal., Exp Mol Pathol. 2011 Jun;90(3):239-43. doi: 10.1016/j.yexmp.2011.01.005. Epub 2011 Jan 25.
45. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. Hepatitis B virus (HBV) induces the expression of interleukin-8 that in turn reduces HBV sensitivity to interferon-alpha. Pollicino T, etal., Virology. 2013 Sep;444(1-2):317-28. doi: 10.1016/j.virol.2013.06.028. Epub 2013 Jul 23.
49. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Rakoff-Nahoum S and Medzhitov R, Science. 2007 Jul 6;317(5834):124-7. doi: 10.1126/science.1140488.
50. GOA pipeline RGD automated data pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Rhee SH, etal., Gastroenterology. 2008 Aug;135(2):518-28. doi: 10.1053/j.gastro.2008.04.022. Epub 2008 Apr 23.
54. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
55. Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma. Royse KE, etal., Int J Mol Epidemiol Genet. 2017 Apr 15;8(2):8-18. eCollection 2017.
56. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. Salcedo R, etal., J Exp Med. 2010 Aug 2;207(8):1625-36. doi: 10.1084/jem.20100199. Epub 2010 Jul 12.
57. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Scheeren FA, etal., Nat Cell Biol. 2014 Dec;16(12):1238-48. doi: 10.1038/ncb3058. Epub 2014 Nov 2.
58. Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. Schiechl G, etal., J Clin Invest. 2011 May;121(5):1692-708. doi: 10.1172/JCI42540. Epub 2011 Apr 25.
59. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
60. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Soltany-Rezaee-Rad M, etal., Gastroenterol Res Pract. 2014;2014:185035. doi: 10.1155/2014/185035. Epub 2014 Jan 8.
61. Deleting MyD88 signaling in myeloid cells promotes development of adenocarcinomas of the colon. Song J, etal., Cancer Lett. 2018 Oct 1;433:65-75. doi: 10.1016/j.canlet.2018.06.036. Epub 2018 Jun 28.
62. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Sun Y, etal., Infect Immun. 2006 Sep;74(9):5325-32.
63. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
64. Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. Vetreno RP, etal., Neurobiol Dis. 2013 Nov;59:52-62. doi: 10.1016/j.nbd.2013.07.002. Epub 2013 Jul 15.
65. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Wang EL, etal., Br J Cancer. 2010 Mar 2;102(5):908-15. doi: 10.1038/sj.bjc.6605558. Epub 2010 Feb 9.
66. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
67. Increased expression of MyD88 and association with paclitaxel resistance in breast cancer. Xiang F, etal., Tumour Biol. 2016 May;37(5):6017-25. doi: 10.1007/s13277-015-4436-5. Epub 2015 Nov 23.
68. Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer. Xie L, etal., J Natl Cancer Inst. 2015 Dec 28;108(4). pii: djv364. doi: 10.1093/jnci/djv364. Print 2016 Apr.
69. Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway. Xin G, etal., Exp Biol Med (Maywood). 2015 Oct;240(10):1279-86. doi: 10.1177/1535370215570189. Epub 2015 Mar 18.
70. IL33 activates CD8+T and NK cells through MyD88 pathway to suppress the lung cancer cell growth in mice. Xu L, etal., Biotechnol Lett. 2020 Jul;42(7):1113-1121. doi: 10.1007/s10529-020-02815-2. Epub 2020 Mar 5.
71. Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification. Xu X, etal., Cell Death Dis. 2017 Oct 12;8(10):e3124. doi: 10.1038/cddis.2017.519.
72. Primary diffuse large B-cell lymphomas of central nervous system exhibit remarkably high prevalence of oncogenic MYD88 and CD79B mutations. Yamada S, etal., Leuk Lymphoma. 2015 Jul;56(7):2141-5. doi: 10.3109/10428194.2014.979413. Epub 2015 Jan 14.
73. Thymosin α1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1. Yuan C, etal., Biochem Biophys Res Commun. 2015 Aug 14;464(1):249-55. doi: 10.1016/j.bbrc.2015.06.132. Epub 2015 Jun 23.
74. Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF-1α-independent VEGF expression and angiogenesis in hepatocellular carcinoma. Zhang C, etal., Br J Pharmacol. 2020 Jul;177(14):3240-3257. doi: 10.1111/bph.15046. Epub 2020 Apr 12.
75. Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways. Zhang L, etal., Oncol Rep. 2019 Nov;42(5):1843-1855. doi: 10.3892/or.2019.7278. Epub 2019 Aug 14.
76. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
77. Toll-like receptor 5 agonist inhibition of growth of A549 lung cancer cells in vivo in a Myd88 dependent manner. Zhou SX, etal., Asian Pac J Cancer Prev. 2012;13(6):2807-12. doi: 10.7314/apjcp.2012.13.6.2807.
78. MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF‑κB/AP‑1 signaling pathway. Zhu G, etal., Int J Mol Med. 2020 Jan;45(1):131-140. doi: 10.3892/ijmm.2019.4390. Epub 2019 Oct 31.
79. Promoter methylation status of ASC/TMS1/PYCARD is associated with decreased overall survival and TNM status in patients with early stage non-small cell lung cancer (NSCLC). Šutić M, etal., Transl Lung Cancer Res. 2019 Dec;8(6):1000-1015. doi: 10.21037/tlcr.2019.12.08.
Additional References at PubMed
PMID:10607756   PMID:10854325   PMID:11067888   PMID:11544529   PMID:12034707   PMID:12477932   PMID:12719478   PMID:12761501   PMID:12855817   PMID:12872135   PMID:14764662   PMID:14993594  
PMID:15294994   PMID:15800576   PMID:16199478   PMID:16259957   PMID:16751103   PMID:16954392   PMID:17258210   PMID:17475835   PMID:17635956   PMID:17660297   PMID:18203139   PMID:18589162  
PMID:19265123   PMID:19281832   PMID:19326394   PMID:19342961   PMID:19509286   PMID:19593445   PMID:20021788   PMID:20037584   PMID:20219467   PMID:21376021   PMID:21516116   PMID:21530945  
PMID:21543208   PMID:21988832   PMID:22155109   PMID:22155231   PMID:23141143   PMID:23633945   PMID:23684713   PMID:24111943   PMID:24429329   PMID:24582748   PMID:24842692   PMID:25084278  
PMID:25169970   PMID:25416956   PMID:25652858   PMID:25695672   PMID:25738964   PMID:25800037   PMID:25810567   PMID:25848864   PMID:25910212   PMID:26119193   PMID:26363072   PMID:26585410  
PMID:26684858   PMID:26895894   PMID:27057550   PMID:27107012   PMID:27107073   PMID:27107801   PMID:27193049   PMID:28161820   PMID:29115455   PMID:29150630   PMID:29304519   PMID:29359143  
PMID:29524303   PMID:29892012   PMID:29940584   PMID:30107238   PMID:30143913   PMID:30883606   PMID:31177708   PMID:31432123   PMID:31939007   PMID:32084554   PMID:32214070   PMID:32240615  
PMID:33236160   PMID:33383282   PMID:33744886   PMID:34260072   PMID:34369678   PMID:34719837   PMID:35959879   PMID:37401890   PMID:38291253  


Genomics

Comparative Map Data
Myd88
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,952,161 - 127,956,230 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,952,161 - 127,956,230 (-)EnsemblGRCr8
mRatBN7.28119,074,439 - 119,078,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,074,437 - 119,079,415 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,656,479 - 124,660,550 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,855,496 - 122,859,567 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,689,025 - 120,693,095 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)Ensemblrn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,225,640 - 118,229,709 (-)NCBICelera
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Cytogenetic Map8q32NCBI
MYD88
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,138,661 - 38,143,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,138,552 - 38,143,024 (+)Ensemblhg38GRCh38
GRCh37338,180,152 - 38,184,513 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,155,009 - 38,159,517 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34338,155,156 - 38,159,514NCBI
Celera338,115,770 - 38,120,314 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,220,931 - 38,225,475 (+)NCBIHuRef
CHM1_1338,131,949 - 38,136,493 (+)NCBICHM1_1
T2T-CHM13v2.0338,144,330 - 38,148,691 (+)NCBIT2T-CHM13v2.0
Myd88
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,165,000 - 119,169,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,165,000 - 119,170,477 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,335,934 - 119,340,018 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,335,934 - 119,341,411 (-)Ensemblmm10GRCm38
MGSCv379119,245,106 - 119,249,158 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369119,184,686 - 119,188,738 (-)NCBIMGSCv36mm8
Celera9119,805,118 - 119,809,170 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Myd88
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,553,589 - 25,559,138 (+)Ensembl
ChiLan1.0NW_00495542725,553,589 - 25,557,654 (+)NCBIChiLan1.0ChiLan1.0
MYD88
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,091,180 - 38,096,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,096,783 - 38,101,258 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,036,565 - 38,041,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,319,024 - 38,323,572 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,319,024 - 38,323,572 (+)EnsemblpanPan2panpan1.1
MYD88
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,901,578 - 7,905,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,901,250 - 7,904,534 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha237,943,535 - 7,947,227 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,191,155 - 8,194,847 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,191,134 - 8,194,847 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,005,061 - 8,008,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,146,176 - 8,149,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,138,449 - 8,142,140 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myd88
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,532,893 - 194,537,794 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,671,797 - 27,676,372 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,672,237 - 27,676,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYD88
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,966,137 - 22,983,109 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11322,976,951 - 22,979,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,181,100 - 25,183,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYD88
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,276,804 - 1,281,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,276,798 - 1,281,166 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606310,006,548 - 10,011,071 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myd88
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,677,290 - 2,681,489 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247312,677,259 - 2,681,408 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Myd88
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18110,570,698 - 110,575,741 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:712
Count of miRNA genes:293
Interacting mature miRNAs:363
Transcripts:ENSRNOT00000018341
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
RH132399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,074,623 - 119,074,819 (+)MAPPERmRatBN7.2
Rnor_6.08128,022,697 - 128,022,892NCBIRnor6.0
Rnor_5.08127,229,458 - 127,229,653UniSTSRnor5.0
RGSC_v3.48124,299,914 - 124,300,109UniSTSRGSC3.4
Celera8118,225,825 - 118,226,020UniSTS
RH 3.4 Map81285.09UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018341   ⟹   ENSRNOP00000018341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,952,161 - 127,956,230 (-)Ensembl
mRatBN7.2 Ensembl8119,074,439 - 119,078,508 (-)Ensembl
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096753   ⟹   ENSRNOP00000081836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,074,442 - 119,079,415 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111747   ⟹   ENSRNOP00000088914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,952,161 - 127,956,230 (-)Ensembl
mRatBN7.2 Ensembl8119,074,439 - 119,078,508 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112994   ⟹   ENSRNOP00000079057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,074,437 - 119,078,508 (-)Ensembl
RefSeq Acc Id: NM_198130   ⟹   NP_937763
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,952,161 - 127,956,230 (-)NCBI
mRatBN7.28119,074,439 - 119,078,508 (-)NCBI
Rnor_6.08128,022,512 - 128,026,581 (-)NCBI
Rnor_5.08127,229,273 - 127,234,226 (-)NCBI
RGSC_v3.48124,299,729 - 124,303,798 (-)RGD
Celera8118,225,640 - 118,229,709 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_937763 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97266 (Get FASTA)   NCBI Sequence Viewer  
  AAO91937 (Get FASTA)   NCBI Sequence Viewer  
  EDL76917 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018341
  ENSRNOP00000018341.3
GenBank Protein Q6Y1S1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_937763   ⟸   NM_198130
- UniProtKB: Q6Y1S1 (UniProtKB/Swiss-Prot),   Q4QRC0 (UniProtKB/Swiss-Prot),   A6I3W0 (UniProtKB/TrEMBL),   A0A8I6AAN0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018341   ⟸   ENSRNOT00000018341
Ensembl Acc Id: ENSRNOP00000079057   ⟸   ENSRNOT00000112994
Ensembl Acc Id: ENSRNOP00000081836   ⟸   ENSRNOT00000096753
Ensembl Acc Id: ENSRNOP00000088914   ⟸   ENSRNOT00000111747
Protein Domains
Death   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6Y1S1-F1-model_v2 AlphaFold Q6Y1S1 1-296 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696369
Promoter ID:EPDNEW_R6894
Type:initiation region
Name:Myd88_1
Description:myeloid differentiation primary response 88
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,026,563 - 128,026,623EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735043 AgrOrtholog
BioCyc Gene G2FUF-28791 BioCyc
Ensembl Genes ENSRNOG00000013634 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018341 ENTREZGENE
  ENSRNOT00000018341.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.10140 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7459961 IMAGE-MGC_LOAD
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  MyD88_Death UniProtKB/Swiss-Prot
  Myelin_different_resp_MyD88 UniProtKB/Swiss-Prot
  TIR_dom UniProtKB/Swiss-Prot
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:301059 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114236 IMAGE-MGC_LOAD
NCBI Gene 301059 ENTREZGENE
PANTHER MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 UniProtKB/Swiss-Prot
  PTHR15079 UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot
  TIR_2 UniProtKB/Swiss-Prot
PhenoGen Myd88 PhenoGen
PIRSF MyD88 UniProtKB/Swiss-Prot
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013634 RatGTEx
SMART DEATH UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF52200 UniProtKB/Swiss-Prot
UniProt A0A8I6AAN0 ENTREZGENE, UniProtKB/TrEMBL
  A6I3W0 ENTREZGENE, UniProtKB/TrEMBL
  MYD88_RAT UniProtKB/Swiss-Prot
  Q4QRC0 ENTREZGENE
  Q6Y1S1 ENTREZGENE
UniProt Secondary Q4QRC0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Myd88  MYD88, innate immune signal transduction adaptor  Myd88  myeloid differentiation primary response 88  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-21 Myd88  myeloid differentiation primary response 88  Myd88  myeloid differentiation primary response gene 88  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Myd88  myeloid differentiation primary response gene 88      Symbol and Name status set to approved 1299863 APPROVED