Gene:	Pik3r2 ( Rattus norvegicus ) phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Description:	regulatory subunit of the enzyme phosphatidylinositol 3-kinase; involved in cellular signaling mechanisms
Synonyms:	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; MGC108697; phosphatidylinositol 3-kinase regulartory subunit polypeptide 2; phosphatidylinositol 3-kinase regulatory subunit polypeptide 2 (p85 beta);  (details...)
ArrayIDs:	1376190_at; 6410542; 5997270; D64046_at; A_44_P158216; 5736778; 6098818; 5832891; 6615821; 5961814; 5711330; 6675594; 6290769; A_43_P12150; 1370100_at; 6555026; 5806361; rc_AI103391_at; 6095837; 5682045; D64046_g_at; 5853356; 6639765; 5963456; GE1299471; 6516405; 6116218; 6330208; 5836371; 6654242; 6147821; 5684758; 6372040; GE1224933; 6034432;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PIK3R2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pik3r2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Pik3r2 genome assembly 3.1 16 19171098 - 19179648     Rat Celera Assembly 16 18857756 - 18866282     RGSC genome assembly v3.4 16 19171101 - 19179650     Cytogenetic 16 p14 Mus musculus Pik3r2 Mouse genome assembly build 36.1 8 73292078 - 73300580     Cytogenetic 8 8 B3.3 Homo sapiens PIK3R2 human genome assembly 19 18125015 - 18142343     Human genome assembly build 36.2 19 18125016 - 18142343     Cytogenetic 19 q13.2-q13.4   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  phosphoinositide 3-kinase regulator activity,  kinase activity ...  (details...)
Biological Process	Gene Ontology negative regulation of anti-apoptosis,  signal transduction (details...)
Cellular Component	Gene Ontology intracellular,  phosphoinositide 3-kinase complex,  cytosol (details...)
Pathway	Ontology phosphatidylinositol 3-kinase-Akt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: RhoGAP IPI SMART: SH3 IPI SMART: SH2 IPI PROSITE: SH2 IPI PROSITE: SH3 IPI PROSITE: RHOGAP IPI UNIPARC: UPI000019C17C IPI UNIPARC: UPI000013106D IPI KEGG Report: rno:29741 ENTREZGENE HomoloGene Group ID: 3687 ENTREZGENE Germonline: 68341 Pfam: RhoGAP IPI Pfam: SH3_1 IPI Pfam: SH2 IPI KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04150 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04070 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 05218 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE InterPro: PI3kinase_P85. IPI InterPro: RhoGAP. IPI InterPro: SH2. IPI InterPro: SH3_domain. IPI InterPro: Rho_GTPase_activation_prot. IPI Ensembl Protein: ENSRNOP00000026210 IPI IPI: IPI00211947 IPI IPI: IPI00554334 IPI Gene3D-CATH: SH2 IPI Gene3D-CATH: RhoGAP IPI Entrez Gene: Pik3r2 ENTREZGENE IMAGE_CLONE: IMAGE:7381613 IMAGE-MGC_LOAD MGC_CLONE: MGC:108697 IMAGE-MGC_LOAD Ensembl Genes: ENSRNOG00000019228 IPI TIGR: TC213981 UniProt: P85B_RAT IPI UniProt: Q5FVS6_RAT IPI Superfamily-SCOP: Rho_GAP IPI Superfamily-SCOP: SH3 IPI PANTHER: PI3kinase_P85 IPI PRINTS: PI3KINASEP85. IPI PRINTS: SH2DOMAIN. IPI
Sequences	Nucleotide: NM_022185 Get FASTA Search GEO Profiles Nucleotide: D64046 Get FASTA Search GEO Profiles Nucleotide: BC089805 Get FASTA Search GEO Profiles Nucleotide: CH474031 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: Q63788 Get FASTA Protein: AAH89805 Get FASTA Protein: BAA10926 Get FASTA Protein: EDL90738 Get FASTA Protein: NP_071521 Get FASTA Protein: EDL90737 Get FASTA Protein: Q5FVS6 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 22497
References
Curated References	8 references in RGD related to Pik3r2
Other References	5 other references at PubMed related to Pik3r2
Database Information
RGD ID	68341
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-SEP-08: Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 18-FEB-08: Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 09-APR-03: Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2 APPROVED Name updated 629478 10-JUN-02: Pik3r2 phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2 APPROVED Name updated 70584 19-FEB-02: Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) APPROVED Name updated 61478