Gene:	Pdx1 ( Rattus norvegicus ) pancreatic and duodenal homeobox 1
Description:	a transcription factor involved in pancreatic alpha and beta cell differentiation, pancreas and central nervous system development, stem cell differentiation and other processes; associated with hyperglycemia, diabetes, placental insufficiency and other diseases
Synonyms:	insulin promotor factor 1; Insulin promoter factor 1; Ipf1; pancreatic and duodenal homeobox gene 1; Idx1; Stf1;
ArrayIDs:	1369516_at; S67435_s_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PDX1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pdx1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Pdx1 Rat Celera Assembly 12 9491415 - 9500671     Rat cytogenetic map 12 Mus musculus Pdx1 Mouse genome assembly build 36.1 5 148081702 - 148087423     Cytogenetic 5 5 G3 Homo sapiens PDX1 human genome assembly 13 27392176 - 27397394     Human genome assembly build 36.2 13 27392177 - 27397410     Cytogenetic 13 q12.1   View comparative maps:
Genome
View:
Annotation
Molecular Function	Gene Ontology RNA polymerase II transcription factor activity,  transcription factor activity,  protein homodimerization activity ...  (details...)
Biological Process	Note Reference involved in maintenance of differentiated beta-cell functions 70227 Gene Ontology positive regulation of insulin secretion,  transdifferentiation,  transcription from RNA polymerase II promoter ...  (details...)
Cellular Component	Gene Ontology nucleus,  intracellular part,  cytoplasm (details...)
Disease	Ontology Diabetes Mellitus, Experimental,  Placental Insufficiency,  Diabetes Mellitus ...  (details...)
Regulation	Note Reference activity inhibited by cytokines such as interteukine1-beta and interferon-gamma, inhibitory effect prevented by blocking NF-kappaB activation or NO production 70227 inhibitory effect can be prevented by blocking NF-kappaB activation or NO production 70227
External Links
Databases	DATABASE ID SOURCE SMART: HOX IPI PROSITE: HOMEOBOX_2 IPI PROSITE: HOMEOBOX_1 IPI UNIPARC: UPI000012D7DB IPI KEGG Report: rno:29535 ENTREZGENE Germonline: 62387 Pfam: Homeobox IPI KEGG Pathway: 04950 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: Homeobox_antennapedia. IPI InterPro: Homeobox_CS. IPI InterPro: Homeodomain-rel. IPI InterPro: Homeodomain-like. IPI InterPro: Homeobox_region. IPI InterPro: Homeobox. IPI IPI: IPI00327500 IPI Gene3D-CATH: Homeodomain-rel IPI Entrez Gene: Pdx1 ENTREZGENE UniProt: PDX1_RAT IPI RatMap: 44316 ENTREZGENE Superfamily-SCOP: Homeodomain_like IPI PRINTS: HOMEOBOX. IPI PRINTS: ANTENNAPEDIA. IPI
Sequences	Nucleotide: U04833 Get FASTA Search GEO Profiles Nucleotide: U39640 Get FASTA Search GEO Profiles Nucleotide: CH474012 Get FASTA Search GEO Profiles Nucleotide: NM_022852 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: P52947 Get FASTA Protein: AAA18355 Get FASTA Protein: EDL89565 Get FASTA Protein: NP_074043 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 54603
References
Curated References	86 references in RGD related to Pdx1
Other References	64 other references at PubMed related to Pdx1
Database Information
RGD ID	62387
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 18-FEB-08: Pdx1 pancreatic and duodenal homeobox 1 Pdx1 pancreatic and duodenal homeobox gene 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Pdx1 pancreatic and duodenal homeobox gene 1 APPROVED Symbol and Name status set to approved 70586 12-JUN-01: Ipf1 Insulin promoter factor 1 WITHDRAWN Symbol withdrawn, duplicate entry of Pdx1(RGD:62387) 62408