RGD Reference Report - Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. - Rat Genome Database

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Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.

Authors: Stoffers, DA  Desai, BM  DeLeon, DD  Simmons, RA 
Citation: Stoffers DA, etal., Diabetes. 2003 Mar;52(3):734-40.
RGD ID: 2311220
Pubmed: PMID:12606515   (View Abstract at PubMed)

Uteroplacental insufficiency resulting in fetal growth retardation is a common complication of pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological studies show an increased incidence of type 2 diabetes in humans who were growth retarded at birth. The mechanisms by which an abnormal intrauterine milieu leads to the development of diabetes in adulthood are not known. Therefore, a rat model of uteroplacental insufficiency was developed; intrauterine growth-retarded (IUGR) rats develop diabetes with a phenotype similar to that observed in the human with type 2 diabetes. We show here that administration of a pancreatic beta-cell trophic factor, exendin-4 (Ex-4), during the prediabetic neonatal period dramatically prevents the development of diabetes in this model. This occurs because neonatal Ex-4 prevents the progressive reduction in insulin-producing beta-cell mass that is observed in IUGR rats over time. Expression of PDX, a critical regulator of pancreas development and islet differentiation, is restored to normal levels, and islet beta-cell proliferation rates are normalized by the neonatal Ex-4 treatment. These results indicate that exposure to Ex-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of diabetes in adulthood.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Fetal Growth Retardation  IEP 2311220mRNA:decreased expression:pancreas (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdx1  (pancreatic and duodenal homeobox 1)

Objects referenced in this article
Gene PDX1 pancreatic and duodenal homeobox 1 Homo sapiens
Gene Pdx1 pancreatic and duodenal homeobox 1 Mus musculus

Additional Information