RGD Reference Report - Effects of biotin on glucotoxicity or lipotoxicity in rat pancreatic islets. - Rat Genome Database

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Effects of biotin on glucotoxicity or lipotoxicity in rat pancreatic islets.

Authors: Yoshikawa, H  Tajiri, Y  Sako, Y  Hashimoto, T  Umeda, F  Nawata, H 
Citation: Yoshikawa H, etal., Metabolism. 2002 Feb;51(2):163-8.
RGD ID: 2311192
Pubmed: PMID:11833042   (View Abstract at PubMed)

Biotin (vitamin H) plays an important role as a cofactor in glucose or lipid metabolism. We showed that biotin potentiated glucose-induced insulin release in isolated rat islets, while biotin alone did not affect insulin release. Coculture with biotin in islets for 48 hours significantly enhanced glucose-induced insulin release or islet insulin content. Similarly, preproinsulin or pancreatic/duodenal homeobox-1 (PDX-1) mRNA was also enhanced in islets cultured with biotin for 48 hours. Furthermore, we measured effects of biotin on beta-cell function under glucotoxic or lipotoxic states. In islets cultured with high glucose or palmitate for 48 hours, glucose-induced insulin release or islet insulin content deteriorated. Coculture with biotin significantly restored glucose-induced insulin release or islet insulin content together with the restoration of preproinsulin or PDX-1 mRNA. We conclude that biotin exerts its beneficial effects on beta-cell dysfunction induced by glucose or free fatty acids probably through the enhancement of insulin biosynthesis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to vitamin  IEP 2311192biotinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdx1  (pancreatic and duodenal homeobox 1)


Additional Information