Gata3 (GATA binding protein 3) - Rat Genome Database

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Gene: Gata3 (GATA binding protein 3) Rattus norvegicus
Analyze
Symbol: Gata3
Name: GATA binding protein 3
RGD ID: 621250
Description: Enables DNA-binding transcription factor activity; histone methyltransferase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cochlea development; response to gamma radiation; and type IV hypersensitivity. Predicted to be located in chromatin. Predicted to be active in nucleus. Biomarker of asthma. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3); PARTICIPATES IN interleukin-27 signaling pathway; Notch signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GATA-binding protein 3; trans-acting T-cell-specific transcription factor GATA-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81773,544,234 - 73,575,670 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1773,553,548 - 73,575,670 (+)EnsemblGRCr8
mRatBN7.21768,643,760 - 68,666,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1768,643,873 - 68,665,391 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1772,127,538 - 72,146,576 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01775,956,280 - 75,975,318 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01769,999,324 - 70,018,364 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01772,419,752 - 72,452,043 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1772,429,618 - 72,450,681 (+)Ensemblrn6Rnor6.0
Rnor_5.01774,114,785 - 74,137,119 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41779,991,587 - 80,011,574 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1768,131,695 - 68,151,337 (+)NCBICelera
RGSC_v3.11780,002,419 - 80,022,407 (+)NCBI
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
13,14-dihydro-15-ketoprostaglandin D2  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-tert-butylhydroquinone  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-galactosylceramide  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
corosolic acid  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
esketamine  (ISO)
ethanol  (EXP)
ethyl 3,4-dihydroxybenzoate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fragrance  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemfibrozil  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
levamisole  (ISO)
Licochalcone B  (ISO)
Mecamylamine  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Mitoquinone  (ISO)
monocrotaline  (ISO)
Morroniside  (EXP,ISO)
N'-Nitrosonornicotine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nonylphenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
remdesivir  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
SR 144528  (ISO)
tacrine  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
thalidomide  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
animal organ development  (IEA)
aortic valve morphogenesis  (IEA,ISO)
axon guidance  (ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac right ventricle morphogenesis  (IEA,ISO)
cartilage development  (IEA,ISO)
cell activation  (ISO)
cell differentiation  (IEA)
cell fate determination  (ISO)
cell maturation  (ISO)
cell morphogenesis  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interferon-alpha  (IEA,ISO)
cellular response to interleukin-4  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
chromatin remodeling  (ISO)
cochlea development  (IEP)
developmental growth  (ISO)
ear development  (IEA,ISO)
embryonic hemopoiesis  (ISO)
embryonic organ development  (ISO)
erythrocyte differentiation  (ISO)
gene expression  (IEA,ISO)
homeostasis of number of cells  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response  (IEA,ISO)
inner ear morphogenesis  (ISO)
kidney development  (IEA,ISO)
lens development in camera-type eye  (ISO)
lymphocyte migration  (IEA,ISO)
macrophage differentiation  (IEA,ISO)
male gonad development  (IEA,ISO)
mast cell differentiation  (ISO)
mesenchymal to epithelial transition  (IEA,ISO)
mesonephros development  (ISO)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of cell motility  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in mesonephros development  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of mammary gland epithelial cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type II interferon production  (ISO)
nephric duct formation  (IEA,ISO)
nephric duct morphogenesis  (IEA,ISO)
nervous system development  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
norepinephrine biosynthetic process  (ISO)
otic vesicle development  (ISO)
parathyroid gland development  (ISO)
parathyroid hormone secretion  (ISO)
pharyngeal system development  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-13 production  (IEA,ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-5 production  (IEA,ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of signal transduction  (IEA,ISO)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of thyroid hormone generation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of ureteric bud formation  (IEA,ISO)
post-embryonic development  (ISO)
pro-T cell differentiation  (ISO)
regulation of CD4-positive, alpha-beta T cell differentiation  (ISO)
regulation of cellular response to X-ray  (IEA,ISO)
regulation of cytokine production  (ISO)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of establishment of cell polarity  (ISO)
regulation of nephron tubule epithelial cell differentiation  (IEA,ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuron projection development  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to estrogen  (IEA,ISO)
response to ethanol  (IEP)
response to gamma radiation  (IEP)
response to virus  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA,ISO)
sympathetic nervous system development  (ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
T cell receptor signaling pathway  (IEA,ISO)
T-helper 2 cell differentiation  (IEA,ISO)
thymic T cell selection  (ISO)
thymus development  (ISO)
TOR signaling  (IEA,ISO)
type IV hypersensitivity  (IEP)
ureter maturation  (ISO)
ureter morphogenesis  (ISO)
ureteric bud formation  (IEA,ISO)
uterus development  (IEA,ISO)
ventricular septum development  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3. Bian T, etal., Chin Med J (Engl). 2006 Apr 20;119(8):640-8.
2. Maternal Endotoxin Exposure Attenuate Allergic Airway Disease in Infant Rats. Cao L, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Jan 29.
3. Modulation of T-Bet and GATA-3 expression in experimental autoimmune thyroiditis rats through ginsenoside treatment. Chen J, etal., Endocr Res. 2016;41(1):28-33. doi: 10.3109/07435800.2015.1066800. Epub 2015 Nov 2.
4. GATA-3 expression in the development of anterior chamber associated immune deviation. Fu T, etal., Chin Med J (Engl). 2005 Dec 5;118(23):2000-4.
5. [GATA-3 in the development of anterior chamber associated immune deviation] Fu T, etal., Zhonghua Yan Ke Za Zhi 2002 Apr;38(4):213-6.
6. Therapeutic and immunoregulatory effect of GATA-binding protein-3/T-box expressed in T-cells ratio of astragalus polysaccharides on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Gao YJ, etal., Chin J Integr Med. 2016 Dec;22(12):918-924. doi: 10.1007/s11655-015-2151-0. Epub 2015 Aug 26.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation. Gremy O, etal., World J Gastroenterol. 2008 Dec 14;14(46):7075-85.
10. Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture. Gross J, etal., Hear Res. 2010 Mar;261(1-2):9-21. doi: 10.1016/j.heares.2009.12.017. Epub 2009 Dec 16.
11. GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection. Guida N, etal., Stroke. 2021 Nov;52(11):3680-3691. doi: 10.1161/STROKEAHA.121.034637. Epub 2021 Oct 25.
12. Structure and expression of the human GATA3 gene. Labastie MC, etal., Genomics 1994 May 1;21(1):1-6.
13. Alterations of T helper lymphocyte subpopulations in sepsis, severe sepsis, and septic shock: a prospective observational study. Li J, etal., Inflammation. 2015;38(3):995-1002. doi: 10.1007/s10753-014-0063-3.
14. The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Marine J and Winoto A, Proc Natl Acad Sci U S A 1991 Aug 15;88(16):7284-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. Nakamura Y, etal., J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):215-22.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders. Rout UK and Clausen P, Neurosci Res. 2009 Jun;64(2):162-9. Epub 2009 Mar 6.
25. Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements. Siegel MD, etal., J Biol Chem 1995 Oct 13;270(41):24548-55.
26. Regulation of aquaporin-2 gene transcription by GATA-3. off. Uchida S, etal., Biochem Biophys Res Commun 1997 Mar 6;232(1):65-8.
27. GATA3 haplo-insufficiency causes human HDR syndrome. Van Esch H, etal., Nature 2000 Jul 27;406(6794):419-22.
28. Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model. Xiong L, etal., Am J Chin Med. 2007;35(6):1011-20.
Additional References at PubMed
PMID:2017177   PMID:7550312   PMID:7720565   PMID:7956841   PMID:8945476   PMID:9043071   PMID:9576834   PMID:9819382   PMID:10037815   PMID:10447238   PMID:10549629   PMID:10556076  
PMID:10631184   PMID:10835639   PMID:11093124   PMID:11135239   PMID:12127263   PMID:12923059   PMID:14643687   PMID:14670303   PMID:15003631   PMID:15016828   PMID:15087456   PMID:15306564  
PMID:15329349   PMID:15662016   PMID:16319112   PMID:16677481   PMID:17082577   PMID:17357106   PMID:17603486   PMID:17658278   PMID:17658279   PMID:18445004   PMID:18554735   PMID:18621058  
PMID:18776904   PMID:18792410   PMID:18955134   PMID:18997793   PMID:19112489   PMID:19232384   PMID:19248180   PMID:19483726   PMID:19623612   PMID:19666510   PMID:19674970   PMID:19723756  
PMID:19735555   PMID:19796622   PMID:19805038   PMID:19934022   PMID:20176728   PMID:20189993   PMID:20368097   PMID:20398510   PMID:20399120   PMID:20484083   PMID:20484821   PMID:20499358  
PMID:20501701   PMID:20554961   PMID:20583921   PMID:20636338   PMID:20696860   PMID:20702712   PMID:20705609   PMID:20706986   PMID:20818386   PMID:20855495   PMID:20855530   PMID:21217760  
PMID:21344672   PMID:21521737   PMID:21536806   PMID:21553382   PMID:21613615   PMID:21731775   PMID:21761347   PMID:21867929   PMID:22070074   PMID:22384571   PMID:22529382   PMID:22588720  
PMID:23426694   PMID:24802759   PMID:24831988   PMID:25001933   PMID:26451614   PMID:31405951   PMID:35780733   PMID:37672715  


Genomics

Comparative Map Data
Gata3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81773,544,234 - 73,575,670 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1773,553,548 - 73,575,670 (+)EnsemblGRCr8
mRatBN7.21768,643,760 - 68,666,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1768,643,873 - 68,665,391 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1772,127,538 - 72,146,576 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01775,956,280 - 75,975,318 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01769,999,324 - 70,018,364 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01772,419,752 - 72,452,043 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1772,429,618 - 72,450,681 (+)Ensemblrn6Rnor6.0
Rnor_5.01774,114,785 - 74,137,119 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41779,991,587 - 80,011,574 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1768,131,695 - 68,151,337 (+)NCBICelera
RGSC_v3.11780,002,419 - 80,022,407 (+)NCBI
Cytogenetic Map17q12.3NCBI
GATA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38108,045,333 - 8,075,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl108,045,315 - 8,075,198 (+)Ensemblhg38GRCh38
GRCh37108,096,651 - 8,117,161 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36108,136,673 - 8,157,170 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34108,136,672 - 8,157,170NCBI
Celera108,022,059 - 8,042,539 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef108,015,002 - 8,035,471 (+)NCBIHuRef
CHM1_1108,096,969 - 8,117,441 (+)NCBICHM1_1
T2T-CHM13v2.0108,046,213 - 8,076,094 (+)NCBIT2T-CHM13v2.0
Gata3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3929,861,889 - 9,894,845 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl29,861,889 - 9,894,845 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3829,857,078 - 9,887,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl29,857,078 - 9,890,034 (-)Ensemblmm10GRCm38
MGSCv3729,778,705 - 9,800,227 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3629,774,931 - 9,795,629 (-)NCBIMGSCv36mm8
Celera29,794,542 - 9,816,062 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map26.69NCBI
Gata3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542124,457,496 - 24,478,744 (+)Ensembl
ChiLan1.0NW_00495542124,448,446 - 24,477,885 (+)NCBIChiLan1.0ChiLan1.0
GATA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2820,603,369 - 20,624,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11020,608,666 - 20,629,453 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0108,075,951 - 8,105,573 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1108,055,853 - 8,086,271 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl108,064,207 - 8,086,272 (+)EnsemblpanPan2panpan1.1
GATA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,068,143 - 28,098,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,069,051 - 28,087,760 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha225,104,703 - 25,134,953 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0228,443,699 - 28,464,623 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl228,444,605 - 28,465,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,552,826 - 25,583,058 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0226,396,168 - 26,425,115 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0227,112,635 - 27,142,926 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gata3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934430,614,585 - 30,645,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364846,780,692 - 6,800,966 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364846,780,692 - 6,800,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1063,367,663 - 63,388,859 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11063,367,684 - 63,397,977 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21069,582,743 - 69,601,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.198,101,404 - 8,122,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl98,101,432 - 8,123,064 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605113,489,149 - 13,518,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247752,994,164 - 3,015,392 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247752,985,077 - 3,014,567 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gata3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11415,891,615 - 15,911,548 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gata3
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000026187
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 138 88 87 56 92 56 6 352 192 11 111 81 92 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000026187   ⟹   ENSRNOP00000026187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1773,553,548 - 73,575,670 (+)Ensembl
mRatBN7.2 Ensembl1768,643,873 - 68,665,391 (+)Ensembl
Rnor_6.0 Ensembl1772,429,618 - 72,450,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101466   ⟹   ENSRNOP00000088644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1768,643,873 - 68,664,097 (+)Ensembl
RefSeq Acc Id: NM_133293   ⟹   NP_579827
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,553,548 - 73,575,670 (+)NCBI
mRatBN7.21768,643,873 - 68,666,000 (+)NCBI
Rnor_6.01772,430,817 - 72,450,140 (+)NCBI
Rnor_5.01774,114,785 - 74,137,119 (+)NCBI
RGSC_v3.41779,991,587 - 80,011,574 (+)RGD
Celera1768,131,695 - 68,151,337 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771893   ⟹   XP_008770115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,553,828 - 73,575,067 (+)NCBI
mRatBN7.21768,644,133 - 68,666,000 (+)NCBI
Rnor_6.01772,430,004 - 72,452,043 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600667   ⟹   XP_017456156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,551,107 - 73,575,067 (+)NCBI
mRatBN7.21768,643,760 - 68,666,000 (+)NCBI
Rnor_6.01772,430,004 - 72,452,043 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276782   ⟹   XP_063132852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,544,234 - 73,575,067 (+)NCBI
RefSeq Acc Id: XM_063276783   ⟹   XP_063132853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,544,240 - 73,575,067 (+)NCBI
RefSeq Acc Id: XM_063276784   ⟹   XP_063132854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,551,107 - 73,573,676 (+)NCBI
RefSeq Acc Id: XM_063276785   ⟹   XP_063132855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81773,551,107 - 73,573,676 (+)NCBI
RefSeq Acc Id: NP_579827   ⟸   NM_133293
- UniProtKB: Q99NH5 (UniProtKB/TrEMBL),   A6JLV3 (UniProtKB/TrEMBL),   A0A8I6A6L1 (UniProtKB/TrEMBL),   F7FAR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770115   ⟸   XM_008771893
- Peptide Label: isoform X1
- UniProtKB: Q99NH5 (UniProtKB/TrEMBL),   A6JLV3 (UniProtKB/TrEMBL),   A0A8I6A6L1 (UniProtKB/TrEMBL),   F7FAR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456156   ⟸   XM_017600667
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6L1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026187   ⟸   ENSRNOT00000026187
Ensembl Acc Id: ENSRNOP00000088644   ⟸   ENSRNOT00000101466
RefSeq Acc Id: XP_063132852   ⟸   XM_063276782
- Peptide Label: isoform X1
- UniProtKB: A6JLV3 (UniProtKB/TrEMBL),   F7FAR3 (UniProtKB/TrEMBL),   Q99NH5 (UniProtKB/TrEMBL),   A0A8I6A6L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132853   ⟸   XM_063276783
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132854   ⟸   XM_063276784
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132855   ⟸   XM_063276785
- Peptide Label: isoform X4
Protein Domains
GATA-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99NH5-F1-model_v2 AlphaFold Q99NH5 1-444 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700562
Promoter ID:EPDNEW_R11085
Type:initiation region
Name:Gata3_1
Description:GATA binding protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01772,430,514 - 72,430,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621250 AgrOrtholog
BioCyc Gene G2FUF-8746 BioCyc
Ensembl Genes ENSRNOG00000019336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026187 ENTREZGENE
  ENSRNOT00000026187.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/TrEMBL
InterPro TF_GATA-1/2/3 UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/TrEMBL
  Znf_GATA UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report rno:85471 UniProtKB/TrEMBL
NCBI Gene 85471 ENTREZGENE
PANTHER PTHR10071 UniProtKB/TrEMBL
  PTHR10071:SF106 UniProtKB/TrEMBL
Pfam GATA UniProtKB/TrEMBL
PhenoGen Gata3 PhenoGen
PIRSF TF_GATA-1/2/3 UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019336 RatGTEx
SMART ZnF_GATA UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8I6A6L1 ENTREZGENE
  A6JLV3 ENTREZGENE, UniProtKB/TrEMBL
  F7FAR3 ENTREZGENE, UniProtKB/TrEMBL
  Q99NH5 ENTREZGENE
UniProt Secondary Q99NH5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gata3  GATA binding protein 3    GATA-binding protein 3  Name updated 1299863 APPROVED
2002-08-07 Gata3  GATA-binding protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression increases at 5, 7, 14, 21 days after anterior chamber inoculation 632697