RGD Reference Report - [GATA-3 in the development of anterior chamber associated immune deviation] - Rat Genome Database

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[GATA-3 in the development of anterior chamber associated immune deviation]

Authors: Fu, T  Yang, P  Huang, X  Zhou, H  Zhong, H  Li, B  Wang, H  Zhang, Z 
Citation: Fu T, etal., Zhonghua Yan Ke Za Zhi 2002 Apr;38(4):213-6.
RGD ID: 632697
Pubmed: PMID:12133389   (View Abstract at PubMed)

OBJECTIVE: To determine the role of GATA-3 (a transcript factor that has influences on Th2 cell differentiation) in the development of anterior chamber associated immune deviation (ACAID). METHOD: Immunohistochemistry and Western blot were used to determine the localization and relative protein levels of GATA-3 respectively at different time points after anterior chamber injection of 50 microgram interphotoreceptor retinoid binding protein (IRBP). RESULT: GATA-3 was detected weakly in normal spleen and increased significantly at 5, 7, 14 and 21 days after anterior chamber inoculation. It was detected mainly in CD(4)(+) T cells in spleen. CONCLUSION: The expression of GATA-3 increases earlier than development of ACAID. It suggests that GATA-3 play an important role in Th2 commitment during ACAID development.

Objects referenced in this article
Gene Gata3 GATA binding protein 3 Rattus norvegicus

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