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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621250
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gata3
Name: GATA binding protein 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GATA3 mRNAPMID:25181051
Gata3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of GATA3 mRNAPMID:26496021
Gata3affects methylationISOGata3 (Mus musculus)6480464CTDbisphenol A affects the methylation of GATA3 promoterPMID:27334623
Gata3decreases expressionISOGATA3 (Homo sapiens)6480464CTDbisphenol A analog results in decreased expression of GATA3 mRNA; bisphenol A results in decreased expression of GATA3 mRNAPMID:26363213 PMID:31536135 PMID:32387340
Gata3increases expressionISOGata3 (Mus musculus)6480464CTDbisphenol A results in increased expression of GATA3 mRNA; bisphenol A results in increased expression of GATA3 proteinPMID:20553123 PMID:27743673 PMID:32156529
Gata3multiple interactionsISOGata3 (Mus musculus)6480464CTDbisphenol A inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Ovalbumin results in increased expression of GATA3 mRNA]]; bisphenol A promotes the reaction [Ovalbumin results in increased expression of GATA3 mRNA]; Phytochemicals inhibits the reaction [bisphenol A results in increased expression of GATA3 protein]PMID:20553123 PMID:32964057 PMID:35533451
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