Gata3 (GATA binding protein 3) - Rat Genome Database

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Gene: Gata3 (GATA binding protein 3) Chinchilla lanigera
Analyze
Symbol: Gata3
Name: GATA binding protein 3
RGD ID: 8779170
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; Notch signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); adult T-cell leukemia/lymphoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: trans-acting T-cell-specific transcription factor GATA-3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542124,457,496 - 24,478,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542124,448,446 - 24,477,885 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
aortic valve morphogenesis  (ISO)
axon guidance  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cell activation  (ISO)
cell fate determination  (ISO)
cell maturation  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to tumor necrosis factor  (ISO)
chromatin remodeling  (ISO)
cochlea development  (ISO)
developmental growth  (ISO)
ear development  (ISO)
embryonic hemopoiesis  (ISO)
embryonic organ development  (ISO)
erythrocyte differentiation  (ISO)
gene expression  (ISO)
homeostasis of number of cells  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response  (ISO)
inner ear morphogenesis  (ISO)
kidney development  (ISO)
lens development in camera-type eye  (ISO)
lymphocyte migration  (ISO)
macrophage differentiation  (ISO)
male gonad development  (ISO)
mast cell differentiation  (ISO)
mesenchymal to epithelial transition  (ISO)
mesonephros development  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell motility  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in mesonephros development  (ISO)
negative regulation of DNA demethylation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of mammary gland epithelial cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type II interferon production  (ISO)
nephric duct formation  (ISO)
nephric duct morphogenesis  (ISO)
nervous system development  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
norepinephrine biosynthetic process  (ISO)
otic vesicle development  (ISO)
parathyroid gland development  (ISO)
parathyroid hormone secretion  (ISO)
pharyngeal system development  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-5 production  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of thyroid hormone generation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of ureteric bud formation  (ISO)
post-embryonic development  (ISO)
pro-T cell differentiation  (ISO)
regulation of cellular response to X-ray  (ISO)
regulation of cytokine production  (ISO)
regulation of establishment of cell polarity  (ISO)
regulation of nephron tubule epithelial cell differentiation  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuron projection development  (ISO)
regulation of T-helper cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to virus  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (ISO)
sympathetic nervous system development  (ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
T cell receptor signaling pathway  (ISO)
T-helper 2 cell differentiation  (ISO)
thymic T cell selection  (ISO)
thymus development  (ISO)
TOR signaling  (ISO)
transcription by RNA polymerase II  (ISO)
type IV hypersensitivity  (ISO)
ureter maturation  (ISO)
ureter morphogenesis  (ISO)
ureteric bud formation  (ISO)
uterus development  (ISO)
ventricular septum development  (ISO)

Cellular Component
chromatin  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gata3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542124,457,496 - 24,478,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542124,448,446 - 24,477,885 (+)NCBIChiLan1.0ChiLan1.0
GATA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38108,045,333 - 8,075,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl108,045,378 - 8,075,198 (+)EnsemblGRCh38hg38GRCh38
GRCh37108,096,651 - 8,117,161 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36108,136,673 - 8,157,170 (+)NCBINCBI36Build 36hg18NCBI36
Build 34108,136,672 - 8,157,170NCBI
Celera108,022,059 - 8,042,539 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef108,015,002 - 8,035,471 (+)NCBIHuRef
CHM1_1108,096,969 - 8,117,441 (+)NCBICHM1_1
T2T-CHM13v2.0108,046,004 - 8,076,094 (+)NCBIT2T-CHM13v2.0
Gata3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3929,861,889 - 9,894,845 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl29,861,889 - 9,894,845 (-)EnsemblGRCm39 Ensembl
GRCm3829,857,078 - 9,887,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl29,857,078 - 9,890,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv3729,778,705 - 9,800,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3629,774,931 - 9,795,629 (-)NCBIMGSCv36mm8
Celera29,794,542 - 9,816,062 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map26.69NCBI
Gata3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81773,544,234 - 73,575,670 (+)NCBIGRCr8
mRatBN7.21768,643,760 - 68,666,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1768,643,873 - 68,665,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1772,127,538 - 72,146,576 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01775,956,280 - 75,975,318 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01769,999,324 - 70,018,364 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01772,419,752 - 72,452,043 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1772,429,618 - 72,450,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01774,114,785 - 74,137,119 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41779,991,587 - 80,011,574 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11780,002,419 - 80,022,407 (+)NCBI
Celera1768,131,695 - 68,151,337 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
GATA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2820,603,369 - 20,624,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11020,608,666 - 20,629,453 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0108,075,951 - 8,105,573 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1108,055,853 - 8,086,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl108,064,207 - 8,086,272 (+)Ensemblpanpan1.1panPan2
GATA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,068,143 - 28,098,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,069,051 - 28,087,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha225,104,703 - 25,134,953 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0228,443,699 - 28,464,623 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl228,444,605 - 28,465,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,552,826 - 25,583,058 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0226,396,168 - 26,425,115 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0227,112,635 - 27,142,926 (-)NCBIUU_Cfam_GSD_1.0
Gata3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934430,614,585 - 30,645,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364846,780,692 - 6,800,966 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364846,780,692 - 6,800,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1063,367,663 - 63,388,859 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11063,367,684 - 63,397,977 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21069,582,743 - 69,601,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.198,101,404 - 8,122,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl98,101,432 - 8,123,064 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605113,489,149 - 13,518,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247752,994,164 - 3,015,392 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247752,985,077 - 3,014,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000014168   ⟹   ENSCLAP00000014011
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542124,457,496 - 24,478,744 (+)Ensembl
RefSeq Acc Id: XM_005383881   ⟹   XP_005383938
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542124,457,496 - 24,477,885 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383882   ⟹   XP_005383939
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542124,448,446 - 24,477,885 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383883   ⟹   XP_005383940
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542124,457,496 - 24,477,885 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005383938 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383939 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383940 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014011
  ENSCLAP00000014011.1
RefSeq Acc Id: XP_005383939   ⟸   XM_005383882
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VK34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383940   ⟸   XM_005383883
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005383938   ⟸   XM_005383881
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VK34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014011   ⟸   ENSCLAT00000014168
Protein Domains
GATA-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014168 ENTREZGENE
  ENSCLAT00000014168.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/TrEMBL
InterPro TF_GATA-2/3 UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/TrEMBL
  Znf_GATA UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Gata3 ENTREZGENE
PANTHER PTHR10071 UniProtKB/TrEMBL
  PTHR10071:SF106 UniProtKB/TrEMBL
Pfam GATA UniProtKB/TrEMBL
PIRSF TF_GATA-1/2/3 UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8C2VK34 ENTREZGENE, UniProtKB/TrEMBL