Acaca (acetyl-CoA carboxylase alpha) - Rat Genome Database

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Gene: Acaca (acetyl-CoA carboxylase alpha) Rattus norvegicus
Analyze
Symbol: Acaca
Name: acetyl-CoA carboxylase alpha
RGD ID: 621248
Description: Enables acetyl-CoA carboxylase activity and biotin binding activity. Involved in fatty acid biosynthetic process; response to nutrient; and response to xenobiotic stimulus. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Used to study steatotic liver disease. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Orthologous to human ACACA (acetyl-CoA carboxylase alpha); PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-carnitine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acac; ACC-alpha; ACC1; acetyl-CoA carboxylase 1; acetyl-coenzyme A carboxylase; acetyl-Coenzyme A carboxylase alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81069,511,627 - 69,773,888 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1069,511,857 - 69,773,888 (+)EnsemblGRCr8
mRatBN7.21069,014,261 - 69,276,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,014,170 - 69,276,457 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1073,702,781 - 73,894,445 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01073,207,804 - 73,399,466 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01068,672,215 - 68,863,878 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01071,519,392 - 71,719,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,536,533 - 71,719,910 (+)Ensemblrn6Rnor6.0
Rnor_5.01071,431,885 - 71,630,271 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41072,483,772 - 72,677,134 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1068,011,070 - 68,201,435 (+)NCBICelera
RGSC_v3.11072,498,141 - 72,691,504 (+)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-pinoresinol  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,8-cineole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
9-oxononanoic acid  (EXP)
acadesine  (EXP)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Aescin  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (EXP,ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
biguanides  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brexpiprazole  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
camphor  (ISO)
cannabidiol  (ISO)
capsazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chicoric acid  (EXP)
chloroethene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (EXP)
choline  (EXP,ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
CL316243  (EXP)
clobetasol  (ISO)
clofazimine  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
crizotinib  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deoxypodophyllotoxin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Diosbulbin B  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
Elemicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erianin  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP,ISO)
ferrostatin-1  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
furfural  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
Ganoderic acid A  (ISO)
Gastrodin  (ISO)
gentamycin  (EXP)
Geraniin  (ISO)
geraniol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glycine betaine  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isosilybin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (EXP,ISO)
lactucin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP)
lipopolysaccharide  (ISO)
liraglutide  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
myriocin  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
nefazodone  (EXP)
neohesperidin  (ISO)
neomycin  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP)
nilotinib  (ISO)
nimesulide  (EXP)
nordihydroguaiaretic acid  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleic acid  (EXP,ISO)
omeprazole  (EXP)
orlistat  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
Pachymic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PD 0325901  (EXP)
penconazole  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propamocarb  (ISO)
protein kinase inhibitor  (ISO)
puerarin  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
rac-lactic acid  (ISO)
raffinose  (ISO)
raspberry ketone  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rosiglitazone  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
ruthenium red  (ISO)
S-allylcysteine  (ISO)
sabinene  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
sertraline  (ISO)
silibinin  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
spathulenol  (ISO)
splitomicin  (ISO)
steviol  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
taurine  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trans-caffeic acid  (ISO)
triacsin C  (ISO)
triazines  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triclocarban  (EXP)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vanillic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
withaferin A  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)
mitochondrion  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Changes in white adipose tissue metabolism induced by resveratrol in rats. Alberdi G, etal., Nutr Metab (Lond). 2011 May 10;8(1):29. doi: 10.1186/1743-7075-8-29.
3. [Biological-molecular trend in psychiatry] Bilikiewicz A Pol Tyg Lek 1978 Jun 26;33(26):1046-50.
4. A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung. Crawford RM, etal., Biochem J. 2005 Nov 15;392(Pt 1):201-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Gertz K, etal., Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. Harwood HJ Jr, etal., J Biol Chem. 2003 Sep 26;278(39):37099-111. Epub 2003 Jul 3.
9. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Vestnik khirurgii imeni I. I. Grekova Kuts NL, etal., Vestn Khir Im I I Grek 1978 Nov;121(11):88-9.
12. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
13. The messenger RNA profiles in liver, hypothalamus, white adipose tissue, and skeletal muscle of female Zucker diabetic fatty rats after topiramate treatment. Liang Y, etal., Metabolism. 2006 Oct;55(10):1411-9.
14. Heterogeneity at the 5' end of rat acetyl-coenzyme A carboxylase mRNA. Lipogenic conditions enhance synthesis of a unique mRNA in liver. Lopez-Casillas F and Kim KH, J Biol Chem 1989 May 5;264(13):7176-84.
15. Structure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase. Lopez-Casillas F, etal., Proc Natl Acad Sci U S A 1988 Aug;85(16):5784-8.
16. Structural features of the acetyl-CoA carboxylase gene: mechanisms for the generation of mRNAs with 5' end heterogeneity. Luo XC, etal., Proc Natl Acad Sci U S A 1989 Jun;86(11):4042-6.
17. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Menendez JA and Lupu R, Nat Rev Cancer. 2007 Oct;7(10):763-77.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Moura MA, etal., Metabolism. 2001 Dec;50(12):1493-8.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. Rathman SC, etal., J Nutr. 2003 Sep;133(9):2857-62.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. Savage DB, etal., J Clin Invest. 2006 Mar;116(3):817-24. Epub 2006 Feb 16.
29. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
30. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD. Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
Additional References at PubMed
PMID:1974251   PMID:2567668   PMID:2573562   PMID:2900138   PMID:7910165   PMID:8954960   PMID:16216881   PMID:16396499   PMID:17210641   PMID:17218081   PMID:17956983   PMID:18280001  
PMID:18381287   PMID:18534630   PMID:18614015   PMID:19618481   PMID:20457939   PMID:20952656   PMID:23376485   PMID:23479225   PMID:26976583   PMID:27352290   PMID:28993954   PMID:29899443  


Genomics

Comparative Map Data
Acaca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81069,511,627 - 69,773,888 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1069,511,857 - 69,773,888 (+)EnsemblGRCr8
mRatBN7.21069,014,261 - 69,276,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,014,170 - 69,276,457 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1073,702,781 - 73,894,445 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01073,207,804 - 73,399,466 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01068,672,215 - 68,863,878 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01071,519,392 - 71,719,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,536,533 - 71,719,910 (+)Ensemblrn6Rnor6.0
Rnor_5.01071,431,885 - 71,630,271 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41072,483,772 - 72,677,134 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1068,011,070 - 68,201,435 (+)NCBICelera
RGSC_v3.11072,498,141 - 72,691,504 (+)NCBI
Cytogenetic Map10q26NCBI
ACACA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381737,084,992 - 37,406,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1737,084,992 - 37,406,836 (-)Ensemblhg38GRCh38
GRCh371735,441,927 - 35,766,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361732,516,040 - 32,841,015 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341732,516,039 - 32,841,015NCBI
Celera1732,264,387 - 32,589,361 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1731,594,734 - 31,704,859 (-)NCBIHuRef
HuRef1731,378,027 - 31,583,939 (-)NCBIHuRef
CHM1_11735,476,555 - 35,798,374 (-)NCBICHM1_1
T2T-CHM13v2.01738,071,975 - 38,396,996 (-)NCBIT2T-CHM13v2.0
Acaca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,020,461 - 84,292,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,020,498 - 84,292,477 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381184,129,635 - 84,401,651 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,129,672 - 84,401,651 (+)Ensemblmm10GRCm38
MGSCv371184,008,940 - 84,215,153 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361184,011,659 - 84,215,878 (+)NCBIMGSCv36mm8
Celera1193,804,708 - 94,012,980 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.29NCBI
Acaca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955451600,254 - 909,892 (+)Ensembl
ChiLan1.0NW_004955451679,033 - 909,892 (+)NCBIChiLan1.0ChiLan1.0
ACACA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21927,347,009 - 27,678,249 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11729,230,527 - 29,559,723 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01719,670,114 - 19,998,903 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11719,969,199 - 20,297,651 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1719,969,205 - 20,297,651 (+)EnsemblpanPan2panpan1.1
ACACA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1936,904,204 - 37,188,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl936,905,293 - 37,187,892 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha936,128,994 - 36,412,715 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0937,714,414 - 37,998,482 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl937,714,417 - 37,998,015 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1936,495,840 - 36,779,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0936,783,386 - 37,067,528 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0936,870,310 - 37,154,200 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acaca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560235,883,567 - 36,147,281 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490927,769 - 1,191,481 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936490927,769 - 1,191,483 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACACA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1238,581,457 - 38,824,712 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11238,580,916 - 38,875,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21240,200,228 - 40,401,426 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACACA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11630,374,166 - 30,704,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1630,452,343 - 30,705,004 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660771,098,931 - 1,432,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acaca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248714,105,067 - 4,412,325 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248714,103,014 - 4,364,690 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acaca
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1986,294,022 - 86,553,521 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acaca
1624 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:53
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000041140
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D17S1255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21069,130,306 - 69,130,416 (+)MAPPERmRatBN7.2
Rnor_6.01071,575,744 - 71,575,853NCBIRnor6.0
Rnor_5.01071,485,875 - 71,485,984UniSTSRnor5.0
RGSC_v3.41072,532,258 - 72,532,367UniSTSRGSC3.4
Celera1068,057,375 - 68,057,484UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF121986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF121987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB871887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB873147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB875018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB879528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB888263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB921072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC929296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC930556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC936937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC945672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC978481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041140   ⟹   ENSRNOP00000049438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1069,066,860 - 69,276,457 (+)Ensembl
Rnor_6.0 Ensembl1071,546,977 - 71,719,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088138   ⟹   ENSRNOP00000073421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1069,597,108 - 69,773,888 (+)Ensembl
mRatBN7.2 Ensembl1069,099,659 - 69,276,457 (+)Ensembl
Rnor_6.0 Ensembl1071,536,533 - 71,719,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101496   ⟹   ENSRNOP00000078963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1069,066,860 - 69,276,457 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115196   ⟹   ENSRNOP00000094595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1069,557,087 - 69,773,884 (+)Ensembl
mRatBN7.2 Ensembl1069,066,860 - 69,276,457 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116202   ⟹   ENSRNOP00000086394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1069,511,857 - 69,773,884 (+)Ensembl
mRatBN7.2 Ensembl1069,014,170 - 69,276,457 (+)Ensembl
RefSeq Acc Id: NM_022193   ⟹   NP_071529
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,580,247 - 69,773,888 (+)NCBI
mRatBN7.21069,082,796 - 69,276,453 (+)NCBI
Rnor_6.01071,519,392 - 71,719,910 (+)NCBI
Rnor_5.01071,431,885 - 71,630,271 (+)NCBI
RGSC_v3.41072,483,772 - 72,677,134 (+)RGD
Celera1068,011,070 - 68,201,435 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086752   ⟹   XP_038942680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,511,627 - 69,773,888 (+)NCBI
mRatBN7.21069,014,261 - 69,276,453 (+)NCBI
RefSeq Acc Id: XM_039086753   ⟹   XP_038942681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,511,627 - 69,773,888 (+)NCBI
mRatBN7.21069,014,261 - 69,276,453 (+)NCBI
RefSeq Acc Id: XM_039086754   ⟹   XP_038942682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,564,138 - 69,773,888 (+)NCBI
mRatBN7.21069,066,698 - 69,276,453 (+)NCBI
RefSeq Acc Id: XM_039086755   ⟹   XP_038942683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,564,138 - 69,773,888 (+)NCBI
mRatBN7.21069,066,698 - 69,276,453 (+)NCBI
RefSeq Acc Id: XM_039086757   ⟹   XP_038942685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,564,138 - 69,773,888 (+)NCBI
mRatBN7.21069,066,698 - 69,276,453 (+)NCBI
RefSeq Acc Id: XM_039086758   ⟹   XP_038942686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,511,767 - 69,773,888 (+)NCBI
mRatBN7.21069,014,504 - 69,276,453 (+)NCBI
RefSeq Acc Id: XM_063269784   ⟹   XP_063125854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,578,015 - 69,773,888 (+)NCBI
RefSeq Acc Id: XM_063269785   ⟹   XP_063125855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81069,564,137 - 69,773,888 (+)NCBI
Protein Sequences
Protein RefSeqs NP_071529 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942680 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942681 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942682 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942683 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942685 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942686 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125854 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125855 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40652 (Get FASTA)   NCBI Sequence Viewer  
  AAA40653 (Get FASTA)   NCBI Sequence Viewer  
  AAA40654 (Get FASTA)   NCBI Sequence Viewer  
  AAA40655 (Get FASTA)   NCBI Sequence Viewer  
  AAA40656 (Get FASTA)   NCBI Sequence Viewer  
  ABL63425 (Get FASTA)   NCBI Sequence Viewer  
  ABL63426 (Get FASTA)   NCBI Sequence Viewer  
  CBF60000 (Get FASTA)   NCBI Sequence Viewer  
  CBF60635 (Get FASTA)   NCBI Sequence Viewer  
  CBF61881 (Get FASTA)   NCBI Sequence Viewer  
  CBF64062 (Get FASTA)   NCBI Sequence Viewer  
  CBF68276 (Get FASTA)   NCBI Sequence Viewer  
  CBF95526 (Get FASTA)   NCBI Sequence Viewer  
  CBU85244 (Get FASTA)   NCBI Sequence Viewer  
  CBU85853 (Get FASTA)   NCBI Sequence Viewer  
  CBU86757 (Get FASTA)   NCBI Sequence Viewer  
  CBU88938 (Get FASTA)   NCBI Sequence Viewer  
  CBU93150 (Get FASTA)   NCBI Sequence Viewer  
  CBV09046 (Get FASTA)   NCBI Sequence Viewer  
  EDM05508 (Get FASTA)   NCBI Sequence Viewer  
  EDM05509 (Get FASTA)   NCBI Sequence Viewer  
  EDM05510 (Get FASTA)   NCBI Sequence Viewer  
  EDM05511 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086394
  ENSRNOP00000094595
GenBank Protein P11497 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071529   ⟸   NM_022193
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   D3ZRA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049438   ⟸   ENSRNOT00000041140
Ensembl Acc Id: ENSRNOP00000073421   ⟸   ENSRNOT00000088138
RefSeq Acc Id: XP_038942680   ⟸   XM_039086752
- Peptide Label: isoform X1
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   A0A8I6A239 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942681   ⟸   XM_039086753
- Peptide Label: isoform X2
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942686   ⟸   XM_039086758
- Peptide Label: isoform X3
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   D3ZRA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942683   ⟸   XM_039086755
- Peptide Label: isoform X3
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   D3ZRA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942682   ⟸   XM_039086754
- Peptide Label: isoform X3
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   D3ZRA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942685   ⟸   XM_039086757
- Peptide Label: isoform X3
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   D3ZRA3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094595   ⟸   ENSRNOT00000115196
Ensembl Acc Id: ENSRNOP00000086394   ⟸   ENSRNOT00000116202
Ensembl Acc Id: ENSRNOP00000078963   ⟸   ENSRNOT00000101496
RefSeq Acc Id: XP_063125855   ⟸   XM_063269785
- Peptide Label: isoform X4
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   A0A8I5ZM24 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125854   ⟸   XM_063269784
- Peptide Label: isoform X3
- UniProtKB: P97902 (UniProtKB/Swiss-Prot),   P11497 (UniProtKB/Swiss-Prot),   A1EC79 (UniProtKB/Swiss-Prot),   D3ZRA3 (UniProtKB/TrEMBL)
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   CoA carboxyltransferase C-terminal   CoA carboxyltransferase N-terminal   Lipoyl-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11497-F1-model_v2 AlphaFold P11497 1-2345 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621248 AgrOrtholog
BioCyc Gene G2FUF-23845 BioCyc
BioCyc Pathway PWY0-1264 [biotin-carboxyl carrier protein assembly] BioCyc
  PWY66-429 [fatty acid biosynthesis initiation (mitochondria)] BioCyc
BioCyc Pathway Image PWY0-1264 BioCyc
  PWY66-429 BioCyc
Ensembl Genes ENSRNOG00000034013 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000115196 ENTREZGENE
  ENSRNOT00000116202 ENTREZGENE
Gene3D-CATH 2-enoyl-CoA Hydratase, Chain A, domain 1 UniProtKB/Swiss-Prot
  2.40.50.100 UniProtKB/Swiss-Prot
  3.30.1490.20 UniProtKB/Swiss-Prot
  3.40.50.20 UniProtKB/Swiss-Prot
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot
  Biotin dependent carboxylase carboxyltransferase UniProtKB/Swiss-Prot
  PreATP-grasp domain UniProtKB/Swiss-Prot
InterPro ACCA UniProtKB/Swiss-Prot
  ACCA_BT UniProtKB/Swiss-Prot
  AcCoA_carboxyl UniProtKB/Swiss-Prot
  AcCoA_COase_cen UniProtKB/Swiss-Prot
  ATP-grasp UniProtKB/Swiss-Prot
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot
  BC-like_N UniProtKB/Swiss-Prot
  Biotin_BS UniProtKB/Swiss-Prot
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot
  Biotin_COase_C UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot
  COA_CT_C UniProtKB/Swiss-Prot
  COA_CT_N UniProtKB/Swiss-Prot
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot
  Rudment_hybrid_motif UniProtKB/Swiss-Prot
  Single_hybrid_motif UniProtKB/Swiss-Prot
KEGG Report rno:60581 UniProtKB/Swiss-Prot
NCBI Gene 60581 ENTREZGENE
PANTHER ACETYL-COA CARBOXYLASE 1 UniProtKB/Swiss-Prot
  ACETYL-COA CARBOXYLASE, ISOFORM A UniProtKB/Swiss-Prot
Pfam ACC_central UniProtKB/Swiss-Prot
  ACCA_BT UniProtKB/Swiss-Prot
  Biotin_carb_C UniProtKB/Swiss-Prot
  Biotin_carb_N UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  Carboxyl_trans UniProtKB/Swiss-Prot
  CPSase_L_D2 UniProtKB/Swiss-Prot
PhenoGen Acaca PhenoGen
PROSITE ATP_GRASP UniProtKB/Swiss-Prot
  BIOTIN UniProtKB/Swiss-Prot
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot
  COA_CT_CTER UniProtKB/Swiss-Prot
  COA_CT_NTER UniProtKB/Swiss-Prot
  CPSASE_1 UniProtKB/Swiss-Prot
  CPSASE_2 UniProtKB/Swiss-Prot
  PS50979 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000034013 RatGTEx
SMART Biotin_carb_C UniProtKB/Swiss-Prot
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF51230 UniProtKB/Swiss-Prot
  SSF51246 UniProtKB/Swiss-Prot
  SSF52096 UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot
UniProt A0A0G2K5G8_RAT UniProtKB/TrEMBL
  A0A8I5ZM24 ENTREZGENE
  A0A8I6A239 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJY1_RAT UniProtKB/TrEMBL
  A1EC79 ENTREZGENE
  A6HHK3_RAT UniProtKB/TrEMBL
  A6HHK5_RAT UniProtKB/TrEMBL
  ACACA_RAT UniProtKB/Swiss-Prot
  D3ZRA3 ENTREZGENE
  P11497 ENTREZGENE
  P97902 ENTREZGENE
UniProt Secondary A1EC79 UniProtKB/Swiss-Prot
  P97902 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acaca  acetyl-CoA carboxylase alpha  Acaca  acetyl-coenzyme A carboxylase alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Acaca  acetyl-coenzyme A carboxylase alpha  Acac  acetyl-coenzyme A carboxylase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Acac  acetyl-coenzyme A carboxylase      Symbol and Name status set to provisional 70820 PROVISIONAL