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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acaca
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acacadecreases expressionISOAcaca (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of ACACA mRNAPMID:31152847
Acacadecreases expressionISOACACA (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of ACACA proteinPMID:24527689
Acacadecreases phosphorylationISOACACA (Homo sapiens)6480464CTDCadmium Chloride results in decreased phosphorylation of ACACA proteinPMID:33127495
Acacamultiple interactionsISOAcaca (Mus musculus)6480464CTD[Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of ACACA mRNA; [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of ACACA mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of ACACA mRNAPMID:23921151 PMID:27814245
Acacamultiple interactionsISOACACA (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACACA mRNAPMID:36602393
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