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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acaca
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:16643
Term: L-methionine
Definition: The L-enantiomer of methionine.
Chemical ID: MESH:D008715
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acacamultiple interactionsEXP 6480464CTD[Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACACA mRNAPMID:19566968
Acacamultiple interactionsISOAcaca (Mus musculus)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACACA mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of ACACA mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of ACACA mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]]; Smoke promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of ACACA mRNA]PMID:18952117 PMID:27773935 PMID:28973532 PMID:31678261
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