Gene:	Pik3r3 ( Rattus norvegicus ) phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Description:	regulatory subunit of phosphatidylinositol 3-kinase, a mediator of various cellular signaling mechanisms; may mediate signaling in brain and muscle
Synonyms:	phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3; phosphatidylinositol 3-kinase p55 subunit;
ArrayIDs:	1369518_at; D64047_at; A_43_P12165; 6044998; 6669358; 5666411; 5781608; 5730476; A_44_P343060; 6327433; 6004680; 5847345; 6570682; 6460843; 6655975; 6603347; 6363892; 5918257; 5873602;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PIK3R3     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pik3r3     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Pik3r3 genome assembly 3.1 5 136502719 - 136571699     Rat Celera Assembly 5 128230224 - 128297191     RGSC genome assembly v3.4 5 136497494 - 136566473     Cytogenetic 5 q36 Mus musculus Pik3r3 Mouse genome assembly build 36.1 4 115894519 - 115975661     Cytogenetic 4 4 D1 Homo sapiens PIK3R3 human genome assembly 1 46217832 - 46310334     Human genome assembly build 36.2 1 46278399 - 46370901     Cytogenetic 1 p34.1   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  1-phosphatidylinositol-3-kinase regulator activity (details...)
Biological Process	Gene Ontology insulin receptor signaling pathway (details...)
Cellular Component	Gene Ontology phosphoinositide 3-kinase complex (details...)
Expression	Note Reference ubiquitously expressed; enriched in brain 68289
Pathway	Ontology phosphatidylinositol 3-kinase-Akt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: SH2 IPI PROSITE: SH2 IPI UNIPARC: UPI00000E8767 IPI UNIPARC: UPI0001B7B4FA IPI KEGG Report: rno:60664 ENTREZGENE HomoloGene Group ID: 2690 ENTREZGENE Germonline: 621042 Pfam: SH2 IPI KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04150 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04070 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 05218 ENTREZGENE InterPro: SH2. IPI InterPro: PI3kinase_P85. IPI IPI: IPI00951573 IPI IPI: IPI00211948 IPI Ensembl Protein: ENSRNOP00000061608 IPI Ensembl Protein: ENSRNOP00000000157 IPI Gene3D-CATH: SH2 IPI Entrez Gene: Pik3r3 ENTREZGENE UniProt: P55G_RAT IPI Ensembl Genes: ENSRNOG00000000145 IPI PANTHER: PI3kinase_P85 IPI PRINTS: SH2DOMAIN. IPI PRINTS: PI3KINASEP85. IPI
Sequences	Nucleotide: CH474008 Get FASTA Search GEO Profiles Nucleotide: D64047 Get FASTA Search GEO Profiles Nucleotide: NM_022213 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: Q63789 Get FASTA Protein: BAA10927 Get FASTA Protein: EDL90282 Get FASTA Protein: NP_071549 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 44448
References
Curated References	6 references in RGD related to Pik3r3
Other References	1 other references at PubMed related to Pik3r3
Database Information
RGD ID	621042
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-SEP-08: Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) Pik3r3 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 22-FEB-08: Pik3r3 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) Pik3r3 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 20-JAN-05: Pik3r3 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 phosphatidylinositol 3-kinase p55 subunit APPROVED Name updated 1299863 07-AUG-02: Pik3r3 phosphatidylinositol 3-kinase p55 subunit PROVISIONAL Symbol and Name status set to provisional 70820