Ccr5 (C-C motif chemokine receptor 5) - Rat Genome Database

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Gene: Ccr5 (C-C motif chemokine receptor 5) Rattus norvegicus
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Symbol: Ccr5
Name: C-C motif chemokine receptor 5
RGD ID: 620596
Description: Enables protein kinase binding activity. Involved in several processes, including negative regulation of axon extension; positive regulation of cytokine production; and response to bacterium. Located in cell surface and endosome. Used to study Alzheimer's disease and plague. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5); PARTICIPATES IN interleukin-12 signaling pathway; chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; Ckr5; Cmkbr5; MIP-1 alpha receptor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,629,097 - 132,660,980 (+)NCBIGRCr8
mRatBN7.28123,752,423 - 123,757,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,343,076 - 129,348,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,542,196 - 127,547,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,360,117 - 125,365,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
allergic contact dermatitis  (IEP)
Alzheimer's disease  (IMP,ISO)
anterior uveitis  (IEP)
Arterial Injury  (IEP)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Birth Injuries  (IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP)
brain ischemia  (IEP)
breast cancer  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (IEP)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO,ISS)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (IEP)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Seizures  (IMP)
fallopian tube disease  (ISO)
Fever  (IMP,ISO)
Flaviviridae Infections  (ISO)
gallbladder cancer  (ISO)
glaucoma  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
hypertension  (IEP,ISO)
Inflammation  (IEP)
interstitial lung disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
keratoconjunctivitis sicca  (ISO)
leishmaniasis  (ISO)
Liver Injury  (IMP)
Lymphatic Metastasis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
multiple sclerosis  (ISO)
Mycoplasma Infections  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
optic neuritis  (ISO)
Oral Lichen Planus  (ISO)
orchitis  (IEP)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
plague  (IAGP)
pleural tuberculosis  (ISO)
pneumonia  (ISO)
posterior uveitis  (ISO)
Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respirovirus Infections  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sjogren's syndrome  (ISO)
status epilepticus  (IEP)
syphilis  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (IEP,ISO)
type 1 diabetes mellitus 22  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
Ulcer  (ISO)
urticaria  (ISO)
uveitis  (IEP)
visceral leishmaniasis  (ISO)
West Nile fever  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-naphthylamine  (ISO)
3-chlorophenol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ancriviroc  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
Cirsimarin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
D-penicillamine  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
enniatin  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
formaldehyde  (ISO)
graphene oxide  (ISO)
indole-3-methanol  (ISO)
isopentenyl diphosphate  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
maraviroc  (ISO)
mechlorethamine  (EXP)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mycotoxin  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
proanthocyanidin  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SCH 23390  (EXP)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
staurosporine  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
calcium ion transport  (ISO)
calcium-mediated signaling  (IBA,ISO)
cell chemotaxis  (IBA)
cell-cell signaling  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
chemokine-mediated signaling pathway  (IEA)
chemotaxis  (IEA)
defense response  (ISO)
defense response to bacterium  (IEP)
fat cell differentiation  (IEP)
forebrain development  (IEP)
G protein-coupled receptor signaling pathway  (ISO)
immune response  (IBA,IEA)
inflammatory response  (IBA,IEA)
inflammatory response to antigenic stimulus  (IEP)
leukocyte migration  (TAS)
MAPK cascade  (ISO)
negative regulation of axon extension  (IMP)
negative regulation of macrophage apoptotic process  (IEA,ISO)
negative regulation of neural precursor cell proliferation  (IMP)
positive regulation of cell killing  (IMP)
positive regulation of cell-cell adhesion  (IMP)
positive regulation of cytosolic calcium ion concentration  (IBA,IMP)
positive regulation of fever generation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron differentiation  (IMP)
positive regulation of tumor necrosis factor production  (IMP)
regulation of cell migration  (IMP)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
response to cholesterol  (ISO)
response to ionizing radiation  (IEP)
response to lipopolysaccharide  (IEP)
signaling  (ISO)

Cellular Component
cell surface  (IDA,ISO)
cytoplasm  (IBA)
endosome  (IDA,ISO)
external side of plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CCR5 Polymorphism as a Protective Factor for Hepatocellular Carcinoma in Hepatitis B Virus-Infected Iranian Patients Abdolmohammadi R, etal., Asian Pac J Cancer Prev. 2016 Oct 1;17(10):4643-4646.
2. Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis. Ahad MA, etal., Mol Vis. 2007 Mar 23;13:388-96.
3. Effects of the CCR5-Delta32 mutation on antiviral treatment in chronic hepatitis C. Ahlenstiel G, etal., J Hepatol. 2003 Aug;39(2):245-52.
4. Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea. Ahn SH, etal., J Med Virol. 2006 Dec;78(12):1564-71. doi: 10.1002/jmv.20739.
5. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy. Al-Abdulhadi SA and Al-Rabia MW, Ann Saudi Med. 2010 Mar-Apr;30(2):115-22.
6. Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact. Almeida-Suhett CP, etal., J Neurotrauma. 2014 Apr 1;31(7):683-90. doi: 10.1089/neu.2013.3029. Epub 2014 Mar 3.
7. Sustained inhibition of corneal neovascularization by genetic ablation of CCR5. Ambati BK, etal., Invest Ophthalmol Vis Sci 2003 Feb;44(2):590-3.
8. M- and T-tropic HIVs promote apoptosis in rat neurons. Bachis A, etal., J Neuroimmune Pharmacol. 2009 Mar;4(1):150-60. Epub 2008 Nov 26.
9. Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion. Barr EL, etal., J Microbiol Immunol Infect. 2005 Aug;38(4):244-54.
10. CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1/ T(H)2 in ocular surface disorders. Baudouin C, etal., J Allergy Clin Immunol. 2005 Sep;116(3):614-9.
11. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
12. Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. Bixler GV, etal., BMC Med Genomics. 2011 May 15;4:40. doi: 10.1186/1755-8794-4-40.
13. Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. Bogdanski P, etal., Int J Clin Pharmacol Ther. 2007 Oct;45(10):563-7.
14. T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease. Boin F, etal., Arthritis Rheum. 2008 Apr;58(4):1165-74.
15. Chemokine and chemokine receptor expression analysis in target organs of acute graft-versus-host disease. Bouazzaoui A, etal., Genes Immun. 2009 Dec;10(8):687-701. Epub 2009 Jul 2.
16. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Bracke KR, etal., Clin Exp Allergy. 2007 Oct;37(10):1467-79.
17. Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis. Brajao de Oliveira K, etal., J Cutan Pathol. 2007 Jan;34(1):27-32.
18. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Braunersreuther V, etal., Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):373-9. Epub 2006 Nov 30.
19. Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Breunis WB, etal., Clin Exp Immunol. 2007 Oct;150(1):83-90. Epub 2007 Aug 2.
20. Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. Brozyna S, etal., COPD. 2009 Feb;6(1):4-16.
21. Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Allergol Immunopathol (Madr). 2013 May 30. pii: S0301-0546(13)00103-1. doi: 10.1016/j.aller.2013.02.003.
22. Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. Burns JC, etal., J Infect Dis. 2005 Jul 15;192(2):344-9. Epub 2005 Jun 8.
23. Increased macrophage inflammatory protein-1alpha and macrophage inflammatory protein-1beta levels in bronchoalveolar lavage fluid of patients affected by different stages of pulmonary sarcoidosis. Capelli A, etal., Am J Respir Crit Care Med. 2002 Jan 15;165(2):236-41.
24. CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis. Capelli A, etal., Eur Respir J. 2005 Apr;25(4):701-7.
25. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. Carr DJ, etal., J Gen Virol. 2006 Mar;87(Pt 3):489-99.
26. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
27. CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver. Choi DY, etal., Arch Toxicol. 2015 Feb;89(2):211-20. doi: 10.1007/s00204-014-1253-3. Epub 2014 Apr 27.
28. Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium. Chung JI, etal., Osteoarthritis Cartilage. 2012 Jan 24.
29. Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemia. Cowell RM, etal., J Neuroimmunol. 2006 Apr;173(1-2):155-65. Epub 2006 Mar 3.
30. Culture and differentiation of preadipocytes in two-dimensional and three-dimensional in vitro systems. Daya S, etal., Differentiation. 2007 Jun;75(5):360-70. Epub 2007 Feb 5.
31. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
32. Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE. Eltayeb S, etal., J Neuroinflammation. 2007 May 7;4:14.
33. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Fadel SA, etal., Eur J Immunol. 2008 Dec;38(12):3376-87.
34. The chemokine receptor CCR5 deletion mutation is associated with MS in HLA-DR4-positive Russians. Favorova OO, etal., Neurology 2002 Nov 26;59(10):1652-5.
35. Female-specific association of C-C chemokine receptor 5 gene polymorphisms with Lofgren's syndrome. Fischer A, etal., J Mol Med. 2008 May;86(5):553-61. Epub 2008 Mar 1.
36. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
37. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Glass WG, etal., Virology. 2001 Sep 15;288(1):8-17. doi: 10.1006/viro.2001.1050.
38. Controls for lung dendritic cell maturation and migration during respiratory viral infection. Grayson MH, etal., J Immunol. 2007 Aug 1;179(3):1438-48.
39. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. Gremy O, etal., World J Gastroenterol. 2006 Aug 21;12(31):4996-5004.
40. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
41. Expression of cell adhesion molecules, chemokines and chemokine receptors involved in leukocyte traffic in rats undergoing autoimmune orchitis. Guazzone VA, etal., Reproduction. 2012 May;143(5):651-62. Epub 2012 Feb 20.
42. Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome. Gulati A, etal., Arch Ophthalmol. 2006 May;124(5):710-6.
43. Chemokine receptor expression in rat adjuvant-induced arthritis. Haas CS, etal., Arthritis Rheum. 2005 Dec;52(12):3718-30.
44. Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Habasque C, etal., Mol Hum Reprod 2002 May;8(5):419-25.
45. Short communication: Influence of active tuberculosis on chemokine and chemokine receptor expression in HIV-infected persons. Hanna LE, etal., AIDS Res Hum Retroviruses. 2005 Dec;21(12):997-1002.
46. Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity. Hartmann B, etal., Inflamm Res. 2006 Aug;55(8):322-34.
47. Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation. Hildebrandt GC, etal., Blood. 2005 Mar 15;105(6):2249-57. Epub 2004 Nov 16.
48. Abnormal expression of chemokine receptors in Behcet's disease: relationship to intracellular Th1/Th2 cytokines and to clinical manifestations. Houman H, etal., J Autoimmun. 2004 Nov;23(3):267-73.
49. Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus. Hu JY, etal., Cytokine. 2013 Apr;62(1):141-5. doi: 10.1016/j.cyto.2013.01.020. Epub 2013 Mar 9.
50. A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. Huik K, etal., PLoS One. 2016 Jun 15;11(6):e0156850. doi: 10.1371/journal.pone.0156850. eCollection 2016.
51. Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus. Hull J, etal., J Infect Dis. 2003 Sep 15;188(6):904-7. Epub 2003 Sep 9.
52. Expression of chemokine receptors CXCR4, CCR2, CCR5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain. Ji JF, etal., Neurosci Lett. 2004 Jan 30;355(3):236-40.
53. Increased expression of RANTES, CCR3 and CCR5 in the lesional skin of patients with atopic eczema. Kato Y, etal., Int Arch Allergy Immunol. 2006;139(3):245-57. Epub 2006 Jan 30.
54. Chemokine receptor 5 big up tri, open32 allele in patients with severe pandemic (H1N1) 2009. Keynan Y, etal., Emerg Infect Dis. 2010 Oct;16(10):1621-2.
55. Induction of RANTES and CCR5 through NF-kappaB activation via MAPK pathway in aged rat gingival tissues. Kim HK, etal., Biotechnol Lett. 2006 Jan;28(1):17-23.
56. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Kohlmeier JE, etal., Immunity. 2008 Jul 18;29(1):101-13.
57. Pathogenesis of herpetic stromal keratitis in CCR5- and/or CXCR3-deficient mice. Komatsu K, etal., Curr Eye Res. 2008 Sep;33(9):736-49. doi: 10.1080/02713680802344716.
58. Decreased pain responses of C-C chemokine receptor 5 knockout mice to chemical or inflammatory stimuli. Lee YK, etal., Neuropharmacology. 2013 Apr;67:57-65. doi: 10.1016/j.neuropharm.2012.10.030. Epub 2012 Nov 9.
59. Effects of neferine on CCL5 and CCR5 expression in SCG of type 2 diabetic rats. Li G, etal., Brain Res Bull. 2013 Jan;90:79-87. doi: 10.1016/j.brainresbull.2012.10.002. Epub 2012 Oct 9.
60. mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
61. Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis. Lindner E, etal., BMC Med Genet. 2007 Jun 12;8:33.
62. [Imbalanced T cell-specific transcription factors T-bet and GATA-3 contributes to type 2 T helper cell polarization in asthmatic patients]. Liu CT, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2004 Jun;27(6):398-402.
63. Immunosuppression with a combination of triptolide and cyclosporin A in rat vascularized groin flap allotransplantation. Liu F, etal., Plast Reconstr Surg. 2013 Mar;131(3):343e-50e. doi: 10.1097/PRS.0b013e31827c6daa.
64. Maraviroc attenuates trauma-hemorrhage-induced hepatic injury through PPAR gamma-dependent pathway in rats. Liu FC, etal., PLoS One. 2013 Oct 18;8(10):e78861. doi: 10.1371/journal.pone.0078861. eCollection 2013.
65. Regulation of CCL5 expression in smooth muscle cells following arterial injury. Liu H, etal., PLoS One. 2012;7(1):e30873. doi: 10.1371/journal.pone.0030873. Epub 2012 Jan 23.
66. Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Lohmann T, etal., Diabetes. 2002 Aug;51(8):2474-80.
67. Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. Louboutin JP, etal., FASEB J. 2010 Oct 12.
68. Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. Ma B, etal., J Clin Invest. 2005 Dec;115(12):3460-72. Epub 2005 Nov 10.
69. CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats. Machado RR, etal., Brain Res. 2007 Jun 9;.
70. The CCR5 delta 32 polymorphism (rs333) is not associated with Sjogren's syndrome or Type 1 Diabetes in Colombians. Maier-Moore JS, etal., Clin Immunol. 2013 Aug;148(2):206-8. doi: 10.1016/j.clim.2013.05.010. Epub 2013 May 24.
71. Toll like receptor 2 and CC chemokine receptor 5 cluster in the lipid raft enhances the susceptibility of Leishmania donovani infection in macrophages. Majumdar SB, etal., Indian J Exp Biol. 2014 Jan;52(1):17-29.
72. Association of CCR2-CCR5 haplotypes and CCL3L1 copy number with Kawasaki Disease, coronary artery lesions, and IVIG responses in Japanese children. Mamtani M, etal., PLoS One. 2010 Jul 7;5(7):e11458. doi: 10.1371/journal.pone.0011458.
73. Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats. Manczak M, etal., J Autoimmun. 2002 Jun;18(4):259-70.
74. CCR5 expression influences the progression of human breast cancer in a p53-dependent manner. Manes S, etal., J Exp Med. 2003 Nov 3;198(9):1381-9.
75. Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines. Mateo T, etal., J Immunol. 2006 May 1;176(9):5577-86.
76. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, etal., PLoS One. 2012;7(10):e47930. doi: 10.1371/journal.pone.0047930. Epub 2012 Oct 24.
77. Chemokine (C-C motif) Receptor 5 Is an Important Pathological Regulator in the Development and Maintenance of Neuropathic Pain. Matsushita K, etal., Anesthesiology. 2014 Feb 28.
78. Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy. Melli G, etal., Brain. 2006 May;129(Pt 5):1330-8. Epub 2006 Mar 14.
79. Immunoregulatory role of nitric oxide in Kilham rat virus-induced autoimmune diabetes in DR-BB rats. Mendez II, etal., J Immunol. 2004 Jul 15;173(2):1327-35.
80. CCR5 and CCR2 gene polymorphisms in hypertensive patients. Mettimano M, etal., Br J Biomed Sci. 2003;60(1):19-21.
81. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
82. Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Milliken D, etal., Clin Cancer Res. 2002 Apr;8(4):1108-14.
83. Association of chemokine receptor 5 (CCR5) delta32 mutation with Behcet's disease is dependent on gender in Iranian patients. Mojtahedi Z, etal., Clin Exp Rheumatol. 2006 Sep-Oct;24(5 Suppl 42):S91-4.
84. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. Moreira AP, etal., J Immunol. 2008 Mar 1;180(5):3049-56.
85. CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice. Moreno C, etal., Hepatology. 2005 Oct;42(4):854-62. doi: 10.1002/hep.20865.
86. Chemokine-receptor upregulation and disease severity in respiratory syncytial virus infection. Morrison PT, etal., Clin Immunol. 2008 Jul;128(1):85-93. Epub 2008 Apr 25.
87. RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects. Nakajima K, etal., Diabetes Care. 2003 Mar;26(3):892-8.
88. Regulation of CC chemokine receptor 5 in hepatitis G virus infection. Nattermann J, etal., AIDS. 2003 Jul 4;17(10):1457-62. doi: 10.1097/01.aids.0000076271.76134.58.
89. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
90. CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects. Nigro L, etal., Med Microbiol Immunol. 2007 Dec;196(4):253-5. Epub 2007 Apr 25.
91. Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. O'Grady SP, etal., Syst Biol Reprod Med. 2010 Aug;56(4):292-302.
92. Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice. Ohnuma A, etal., Exp Toxicol Pathol. 2009 Sep 15.
93. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
94. Attenuation of rodent neuropathic pain by an orally active peptide, RAP-103, which potently blocks CCR2- and CCR5-mediated monocyte chemotaxis and inflammation. Padi SS, etal., Pain. 2012 Jan;153(1):95-106. doi: 10.1016/j.pain.2011.09.022. Epub 2011 Oct 26.
95. Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. Pai JK, etal., Atherosclerosis. 2006 May;186(1):132-9. Epub 2005 Aug 1.
96. C-C chemokine receptor type 5 deficiency exacerbates alcoholic fatty liver disease through pro-inflammatory cytokines and chemokines-induced hepatic inflammation. Park JH, etal., J Gastroenterol Hepatol. 2017 Jun;32(6):1258-1264. doi: 10.1111/jgh.13657.
97. Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation. Park MH, etal., Exp Cell Res. 2009 Oct 1;315(16):2715-26. Epub 2009 Jun 24.
98. Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis. Pashenkov M, etal., Clin Exp Immunol. 2002 Mar;127(3):519-26.
99. CC chemokine receptor 5 and interleukin-1 receptor antagonist gene polymorphisms in patients with primary Sjogren's syndrome. Petrek M, etal., Clin Exp Rheumatol. 2002 Sep-Oct;20(5):701-3.
100. CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction. Petrkova J, etal., J Intern Med. 2005 Jun;257(6):564-6.
101. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
102. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
103. Differential upregulation of chemokine receptors on CD56 NK cells and their transmigration to the site of infection in tuberculous pleurisy. Pokkali S, etal., FEMS Immunol Med Microbiol. 2009 Apr;55(3):352-60. Epub 2009 Jan 12.
104. Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. Pollok-Kopp B, etal., J Biol Chem 2003 Jan 24;278(4):2190-8.
105. Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout mice. Potteaux S, etal., Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1858-63. Epub 2006 Jun 8.
106. Negative association between the chemokine receptor CCR5-Delta32 polymorphism and rheumatoid arthritis: a meta-analysis. Prahalad S Genes Immun. 2006 Apr;7(3):264-8.
107. Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. Prahalad S, etal., Genes Immun. 2006 Sep;7(6):468-75. Epub 2006 Jun 15.
108. Association of TGFbeta1, TNFalpha, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians. Prasad P, etal., BMC Med Genet. 2007 Apr 12;8:20.
109. GOA pipeline RGD automated data pipeline
110. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
111. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
112. Effect of the chemokine receptor CCR5 in the development of American cutaneous leishmaniasis in a Southern Brazilian population. Ribas AD, etal., Mol Med Rep. 2013 Jul;8(1):189-94. doi: 10.3892/mmr.2013.1452. Epub 2013 Apr 30.
113. HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Ronaldson PT and Bendayan R, Mol Pharmacol. 2006 Sep;70(3):1087-98. Epub 2006 Jun 21.
114. Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Rosi S, etal., Neuroscience. 2005;134(2):671-6.
115. CC chemokine receptor 5 gene polymorphisms in beryllium disease. Sato H, etal., Eur Respir J. 2010 Aug;36(2):331-8. Epub 2010 Jan 14.
116. CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis. Sato H, etal., Eur Respir J. 2010 Feb;35(2):324-30. Epub 2009 Aug 13.
117. Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. Sato N, etal., J Immunol. 1999 Nov 15;163(10):5519-25.
118. Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation. Sbrana S, etal., Cytometry B Clin Cytom. 2005 May;65(1):14-21.
119. Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. Schaier M, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F769-80. Epub 2009 Jun 17.
120. CCR1 and CCR5 promote hepatic fibrosis in mice. Seki E, etal., J Clin Invest. 2009 Jul;119(7):1858-70.
121. CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. Serra AM, etal., Am J Pathol. 2012 Aug;181(2):719-27. doi: 10.1016/j.ajpath.2012.04.009. Epub 2012 Jun 4.
122. Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Shahrara S, etal., Arthritis Rheum. 2003 Dec;48(12):3568-83.
123. Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. Sheffield JS, etal., J Infect Dis. 2007 Nov 15;196(10):1509-16. Epub 2007 Oct 31.
124. Role of CC-chemokine receptor 5 on myocardial ischemia-reperfusion injury in rats. Shen B, etal., Mol Cell Biochem. 2013 Jun;378(1-2):137-44. doi: 10.1007/s11010-013-1604-z. Epub 2013 Mar 3.
125. CD8 chemokine receptors in chronic obstructive pulmonary disease. Smyth LJ, etal., Clin Exp Immunol. 2008 Oct;154(1):56-63. Epub 2008 Aug 22.
126. Chemokine ligand (CCL)-3 promotes an integrated febrile response when injected within pre-optic area (POA) of rats and induces calcium signaling in cells of POA microcultures but not TNF-alpha or IL-6 synthesis. Soares DM, etal., Brain Behav Immun. 2013 Nov;34:120-9. doi: 10.1016/j.bbi.2013.08.005. Epub 2013 Aug 30.
127. Psoriasis patients exhibit impairment of the high potency CCR5(+) T regulatory cell subset. Soler DC, etal., Clin Immunol. 2013 Oct;149(1):111-8. doi: 10.1016/j.clim.2013.06.007. Epub 2013 Jul 6.
128. Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain. Spleiss O, etal., J Neurosci Res 1998 Jul 1;53(1):16-28.
129. CCR5 Delta32 polymorphism: associated with gallbladder cancer susceptibility. Srivastava A, etal., Scand J Immunol. 2008 May;67(5):516-22.
130. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
131. RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans. Suffee N, etal., Angiogenesis. 2012 Dec;15(4):727-44. doi: 10.1007/s10456-012-9285-x. Epub 2012 Jun 30.
132. Cytokine and chemokine transcription profile during Mycoplasma pulmonis infection in susceptible and resistant strains of mice: macrophage inflammatory protein 1beta (CCL4) and monocyte chemoattractant protein 2 (CCL8) and accumulation of CCR5+ Th cells. Sun X, etal., Infect Immun. 2006 Oct;74(10):5943-54.
133. A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Suzaki Y, etal., Eur Respir J. 2008 Apr;31(4):783-9. Epub 2007 Dec 19.
134. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. Tan MC, etal., J Immunol. 2009 Feb 1;182(3):1746-55.
135. Differential sensitivities of pyrogenic chemokine fevers to CC chemokine receptor 5 antibodies. Tavares E and Minano FJ, Fundam Clin Pharmacol. 2004 Apr;18(2):163-9.
136. Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid. Teleshova N, etal., J Neurol. 2002 Jun;249(6):723-9.
137. RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke. Tokami H, etal., Brain Res. 2013 Jun 23;1517:122-32. doi: 10.1016/j.brainres.2013.04.022. Epub 2013 Apr 18.
138. CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar. Tollenaere C, etal., Infect Genet Evol. 2008 Dec;8(6):891-7. Epub 2008 Jul 25.
139. Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis. Trinh L, etal., Mol Vis. 2008;14:2428-34. Epub 2008 Dec 19.
140. CCR5 Delta 32 mutation, Mycoplasma pneumoniae infection, and asthma. Ungvari I, etal., J Allergy Clin Immunol. 2007 Jun;119(6):1545-7. Epub 2007 Apr 18.
141. Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors. Vassiliadis S, etal., JOP 2002 May;3(3):66-75.
142. CCR5 antagonist blocks metastasis of basal breast cancer cells. Velasco-Velazquez M, etal., Cancer Res. 2012 Aug 1;72(15):3839-50. doi: 10.1158/0008-5472.CAN-11-3917. Epub 2012 May 25.
143. Immune regulation and vascular inflammation in genetic hypertension. Viel EC, etal., Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H938-44. Epub 2009 Dec 31.
144. Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis. Vilela MC, etal., BMC Neurosci. 2013 Feb 7;14:19. doi: 10.1186/1471-2202-14-19.
145. Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. Walker JK, etal., Am J Respir Cell Mol Biol. 2006 Jun;34(6):711-8. Epub 2006 Feb 10.
146. CC chemokine receptor 5 delta32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia. Wasmuth HE, etal., J Mol Med (Berl). 2004 Jan;82(1):64-9. doi: 10.1007/s00109-003-0505-0. Epub 2003 Dec 13.
147. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Woitas RP, etal., Gastroenterology. 2002 Jun;122(7):1721-8.
148. Cytokine expression after vaginal distention of different durations in virgin Sprague-Dawley rats. Wood HM, etal., J Urol. 2008 Aug;180(2):753-9. Epub 2008 Jun 13.
149. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Xia MQ, etal., Am J Pathol. 1998 Jul;153(1):31-7.
150. Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis. Yang CH, etal., Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1339-47.
151. Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behcet's disease. Yang X, etal., Eur J Immunogenet. 2004 Feb;31(1):11-4.
152. Inhibition of chemokine receptor CCR2 and CCR5 expression contributes to simvastatin-induced attenuation of cardiac allograft vasculopathy. Yin R, etal., J Heart Lung Transplant. 2007 May;26(5):485-93.
153. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China. Zhang C, etal., J Int Med Res. 2018 Feb;46(2):739-751. doi: 10.1177/0300060517730174. Epub 2017 Sep 20.
154. Genetic variations in CC chemokine receptors and hypertension. Zhang M, etal., Am J Hypertens. 2006 Jan;19(1):67-72.
155. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. Zhang RX, etal., J Investig Allergol Clin Immunol. 2007;17(5):329-36.
156. Association of chemotactic factor receptor 5 gene with breast cancer. Zhang Y, etal., Genet Mol Res. 2013 Nov 7;12(4):5289-300. doi: 10.4238/2013.November.7.4.
157. The significance for chronic rejection of cardiac allograft of regulated upon activation normal T-cell cytokine and its CCR5 receptor. Zhao H, etal., Transplant Proc. 2013 Mar;45(2):635-8. doi: 10.1016/j.transproceed.2012.03.065.
158. Relative importance of CCR5 and antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis. Zhou Y, etal., J Rheumatol. 2003 Jul;30(7):1541-7.
159. Characterization of the expression of macrophage inflammatory protein-1alpha (MIP-1alpha) and C-C chemokine receptor 5 (CCR5) after kainic acid-induced status epilepticus (SE) in juvenile rats. Zhu XB, etal., Neuropathol Appl Neurobiol. 2012 Oct;38(6):602-16. doi: 10.1111/j.1365-2990.2012.01251.x.
Additional References at PubMed
PMID:8631787   PMID:8699119   PMID:9139699   PMID:9655467   PMID:10383387   PMID:10521508   PMID:10528159   PMID:10679098   PMID:11278962   PMID:12032188   PMID:12421915   PMID:16208318  
PMID:16301745   PMID:16841089   PMID:18230715   PMID:18632580   PMID:19008373   PMID:19523456   PMID:21515370   PMID:22353418   PMID:23610400   PMID:23620790   PMID:24086760   PMID:25300256  
PMID:26550961   PMID:26740279   PMID:26983670   PMID:27848062   PMID:31574524   PMID:32446198   PMID:34774582   PMID:34843718  


Genomics

Comparative Map Data
Ccr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,629,097 - 132,660,980 (+)NCBIGRCr8
mRatBN7.28123,752,423 - 123,757,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,343,076 - 129,348,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,542,196 - 127,547,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,360,117 - 125,365,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,370,142 - 46,376,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,370,946 - 46,376,206 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,411,633 - 46,417,697 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,386,637 - 46,392,701 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,348,960 - 46,355,024 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,455,276 - 46,461,340 (+)NCBIHuRef
CHM1_1346,361,630 - 46,367,689 (+)NCBICHM1_1
T2T-CHM13v2.0346,385,976 - 46,392,040 (+)NCBIT2T-CHM13v2.0
Ccr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,921,557 - 123,934,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,921,580 - 123,947,736 (+)EnsemblGRCm39 Ensembl
GRCm389124,121,543 - 124,127,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,121,543 - 124,147,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,036,282 - 124,041,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9124,872,533 - 124,878,180 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
CCR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,330,233 - 46,335,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,335,001 - 46,340,376 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,273,096 - 46,278,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,377,564 - 47,383,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,380,321 - 47,381,379 (+)Ensemblpanpan1.1panPan2
CCR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,293,288 - 42,297,952 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,294,996 - 42,297,952 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,210,909 - 42,213,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,775,514 - 42,780,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,775,514 - 42,780,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,018,434 - 42,021,393 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,419,865 - 42,422,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,700,801 - 42,703,760 (-)NCBIUU_Cfam_GSD_1.0
CCR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,383,303 - 29,387,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,382,383 - 29,387,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,546,545 - 32,551,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,803,794 - 7,818,112 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,335,032 - 159,341,705 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccr5
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000075564
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat

Markers in Region
Cmkbr5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,756,008 - 123,756,165 (+)MAPPERmRatBN7.2
Rnor_6.08133,214,070 - 133,214,226NCBIRnor6.0
Rnor_5.08132,366,250 - 132,366,406UniSTSRnor5.0
RGSC_v3.48128,910,743 - 128,910,899UniSTSRGSC3.4
Celera8122,851,258 - 122,851,414UniSTS
Cytogenetic Map8q32UniSTS
PMC122923P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,755,127 - 123,755,373 (+)MAPPERmRatBN7.2
Rnor_6.08133,213,189 - 133,213,434NCBIRnor6.0
Rnor_5.08132,365,369 - 132,365,614UniSTSRnor5.0
RGSC_v3.48128,909,862 - 128,910,107UniSTSRGSC3.4
Celera8122,850,377 - 122,850,622UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 91 90 59 25 59 6 216 95 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000075564   ⟹   ENSRNOP00000066146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8133,197,032 - 133,214,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082774   ⟹   ENSRNOP00000073121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)Ensembl
Rnor_6.0 Ensembl8133,210,473 - 133,215,614 (+)Ensembl
RefSeq Acc Id: NM_053960   ⟹   NP_446412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,843 - 132,634,958 (+)NCBI
mRatBN7.28123,752,423 - 123,757,538 (+)NCBI
Rnor_6.08133,210,484 - 133,215,599 (+)NCBI
Rnor_5.08132,362,664 - 132,367,779 (+)NCBI
RGSC_v3.48128,907,157 - 128,912,272 (+)RGD
Celera8122,847,673 - 122,852,786 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264783   ⟹   XP_063120853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: XM_063264784   ⟹   XP_063120854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: XR_010053918
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: XR_010053919
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: NP_446412   ⟸   NM_053960
- UniProtKB: Q68G28 (UniProtKB/TrEMBL),   A6I4D3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073121   ⟸   ENSRNOT00000082774
Ensembl Acc Id: ENSRNOP00000066146   ⟸   ENSRNOT00000075564
RefSeq Acc Id: XP_063120853   ⟸   XM_063264783
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120854   ⟸   XM_063264784
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08556-F1-model_v2 AlphaFold O08556 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696416
Promoter ID:EPDNEW_R6941
Type:initiation region
Name:Ccr5_1
Description:chemokine (C-C motif) receptor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08133,210,484 - 133,210,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620596 AgrOrtholog
BioCyc Gene G2FUF-28594 BioCyc
Ensembl Genes ENSRNOG00000049115 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055002419 UniProtKB/Swiss-Prot
  ENSRNOG00060023387 UniProtKB/Swiss-Prot
  ENSRNOG00065000760 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082774.2 UniProtKB/TrEMBL
  ENSRNOT00055003842 UniProtKB/Swiss-Prot
  ENSRNOT00060040498 UniProtKB/Swiss-Prot
  ENSRNOT00065001050 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109679 IMAGE-MGC_LOAD
InterPro Chemokine_CCR5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117029 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93260 IMAGE-MGC_LOAD
NCBI Gene 117029 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CCR5 RGD
PhenoGen Ccr5 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049115 RatGTEx
  ENSRNOG00055002419 RatGTEx
  ENSRNOG00060023387 RatGTEx
  ENSRNOG00065000760 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I4D3 ENTREZGENE, UniProtKB/TrEMBL
  A6I4D4_RAT UniProtKB/TrEMBL
  CCR5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G28 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Ccr5  C-C motif chemokine receptor 5  Ccr5  chemokine (C-C motif) receptor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ccr5  chemokine (C-C motif) receptor 5    chemokine (C-C) receptor 5  Name updated 1299863 APPROVED
2004-09-10 Ccr5  chemokine (C-C) receptor 5  Cmkbr5    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cmkbr5  chemokine (C-C) receptor 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated by GPCR kinase (GRK)- and protein kinase C (PKC) following RANTES/CCL5 binding to receptor 632395
gene_regulation expression upregulated following bacterial infection 632396
gene_regulation downregulation of receptor is induced by interleukin-1beta 632389