Gene:	Rac1 ( Rattus norvegicus ) ras-related C3 botulinum toxin substrate 1
Description:	small GTP-binding protein involved in signal transduction
Synonyms:	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1);
ArrayIDs:	5967821; 1388332_at; 1391048_at; rc_AA799542_at; rc_AI103616_at; A_44_P164804; 6216279; 1372513_at; 6346114; 5637054; AA848238_at; 5690816; 6290047; GE13970; 6108103; A_44_P395709; 5873918; 5660358;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: RAC1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Rac1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Rac1 Rat Celera Assembly 12 12831091 - 12851324     RGSC genome assembly v3.4 12 11380314 - 11400531     Cytogenetic 12 p11     genome assembly 3.1 12 11419965 - 11428962 Mus musculus Rac1 Mouse genome assembly build 36.1 5 144266349 - 144288861     Cytogenetic 5 5 G2 Homo sapiens RAC1 Human genome assembly build 36.2 7 6380651 - 6410123     Cytogenetic 7 p22   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology GTP binding,  protein binding,  nucleotide binding ...  (details...)
Biological Process	Note Reference essential for leukotriene B4 induced production of reactive oxygen species, chemotaxis, and cellular proliferation 1299245 may play a role in synaptic plasticity in brain 1299238 may play a role in cellular motility through regulation by stretch tension 1299247 enhanced the expression of a kappaB and induced the degradation of IkappaBalpha 704329 Gene Ontology endocytosis,  induction of apoptosis by extracellular signals,  cell migration ...  (details...)
Cellular Component	Note Reference colocalizes at the plasma membrane of RBL-2H3 cells in actin-rich structures with phospholipase D, ARF6, and PKC alpha following antigen stimulation 727254 Gene Ontology lamellipodium,  cell projection,  cytoplasm ...  (details...)
Disease	Ontology Heart Failure, Congestive,  Hypertrophy, Left Ventricular,  Cardiomegaly (details...)
Expression	Note Reference expressed in hippocampus and cerebellum 1299238
Pathway	Ontology p38 MAPK signaling pathway,  c-Jun N-terminal kinases MAPK signaling pathway,  Rho/Rac/Cdc42 mediated signaling pathway ...  (details...)
Regulation	Note Reference activated by treatment of cells with lipopolysaccharide (LPS) 1299246
External Links
Databases	DATABASE ID SOURCE SMART: RHO IPI PROSITE: RHO IPI UNIPARC: UPI0000DC16C8 IPI UNIPARC: UPI000000060F IPI KEGG Report: rno:363875 ENTREZGENE HomoloGene Group ID: 69035 ENTREZGENE Germonline: 619755 Pfam: Ras IPI KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 04520 ENTREZGENE KEGG Pathway: 05014 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE InterPro: Small_GTP_bd. IPI InterPro: GTPase_Rho. IPI InterPro: Ras. IPI InterPro: Ras_GTPase. IPI IPI: IPI00780227 IPI IPI: IPI00422092 IPI Ensembl Protein: ENSRNOP00000001417 IPI Ensembl Protein: ENSRNOP00000057449 IPI Entrez Gene: Rac1 ENTREZGENE UniProt: Q923X0_RAT IPI UniProt: RAC1_RAT IPI Ensembl Genes: ENSRNOG00000001068 IPI TIGRFAMs: small_GTP IPI PRINTS: RASTRNSFRMNG. IPI
Sequences	Nucleotide: CH474012 Get FASTA Search GEO Profiles Nucleotide: AF385833 Get FASTA Search GEO Profiles Nucleotide: AY491395 Get FASTA Search GEO Profiles Nucleotide: NM_134366 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: AAR84574 Get FASTA Protein: Q6RUV5 Get FASTA Protein: AAK66567 Get FASTA Protein: EDL89666 Get FASTA Protein: Q923X0 Get FASTA Protein: EDL89664 Get FASTA Protein: NP_599193 Get FASTA Protein: EDL89665 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 29157
References
Curated References	19 references in RGD related to Rac1
Other References	78 other references at PubMed related to Rac1
Database Information
RGD ID	619755
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 20-JAN-05: Rac1 ras-related C3 botulinum toxin substrate 1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) APPROVED Name updated 1299863 07-AUG-02: Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) PROVISIONAL Symbol and Name status set to provisional 70820