RAC1 (Rac family small GTPase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: RAC1 (Rac family small GTPase 1) Chlorocebus sabaeus
Analyze
Symbol: RAC1
Name: Rac family small GTPase 1
RGD ID: 18498455
Description: ENCODES a protein that exhibits ATPase binding (ortholog); G protein activity (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN cell projection (ortholog); cytosol (ortholog); early endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,583,609 - 15,610,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actin filament organization  (ISO)
actin filament polymerization  (ISO)
anatomical structure arrangement  (ISO)
angiotensin-activated signaling pathway involved in heart process  (ISO)
auditory receptor cell morphogenesis  (ISO)
axon guidance  (ISO)
bone resorption  (ISO)
cell adhesion  (ISO)
cell migration  (IEA,ISO)
cell motility  (IEA)
cell-cell junction organization  (ISO)
cellular response to mechanical stimulus  (ISO)
cerebral cortex GABAergic interneuron development  (ISO)
cerebral cortex radially oriented cell migration  (ISO)
chemotaxis  (ISO)
cochlea morphogenesis  (ISO)
cortical cytoskeleton organization  (IEA)
cytoskeleton organization  (ISO)
dendrite development  (ISO)
dendrite morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic olfactory bulb interneuron precursor migration  (ISO)
endocytosis  (ISO)
engulfment of apoptotic cell  (IEA)
enzyme-linked receptor protein signaling pathway  (ISO)
epithelial cell morphogenesis  (ISO)
erythrocyte enucleation  (ISO)
establishment or maintenance of cell polarity  (IEA)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
homeostasis of number of cells within a tissue  (ISO)
hyperosmotic response  (ISO)
interneuron migration  (ISO)
lamellipodium assembly  (IEA,ISO)
localization within membrane  (IEA)
mast cell chemotaxis  (ISO)
midbrain dopaminergic neuron differentiation  (ISO)
motor neuron axon guidance  (IEA)
negative regulation of fibroblast migration  (IEA)
negative regulation of interleukin-23 production  (IEA)
neuron migration  (ISO)
neuron projection morphogenesis  (ISO)
non-canonical Wnt signaling pathway  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell-substrate adhesion  (IEA)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of filopodium assembly  (ISO)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of microtubule polymerization  (IEA)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of ovarian follicle development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
postsynaptic actin cytoskeleton organization  (ISO)
protein localization to plasma membrane  (ISO)
Rac protein signal transduction  (ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of cell adhesion involved in heart morphogenesis  (ISO)
regulation of cell migration  (IEA)
regulation of cell morphogenesis  (ISO)
regulation of cell shape  (IEA)
regulation of cell size  (IEA)
regulation of ERK5 cascade  (ISO)
regulation of fibroblast migration  (ISO)
regulation of lamellipodium assembly  (IEA)
regulation of neuron maturation  (ISO)
regulation of neuron migration  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of postsynapse assembly  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of respiratory burst  (IEA)
regulation of stress fiber assembly  (IEA)
regulation of synaptic vesicle endocytosis  (ISO)
response to lipopolysaccharide  (ISO)
ruffle assembly  (IEA)
ruffle organization  (IEA,ISO)
semaphorin-plexin signaling pathway  (ISO)
small GTPase-mediated signal transduction  (IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA)
substrate adhesion-dependent cell spreading  (IEA,ISO)
synaptic transmission, GABAergic  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,583,609 - 15,610,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,374,527 - 6,403,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,374,527 - 6,403,967 (+)EnsemblGRCh38hg38GRCh38
GRCh3776,414,158 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,380,651 - 6,410,123 (+)NCBINCBI36Build 36hg18NCBI36
Celera76,291,529 - 6,321,004 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,287,239 - 6,316,490 (+)NCBIHuRef
CHM1_176,413,683 - 6,443,197 (+)NCBICHM1_1
T2T-CHM13v2.076,493,927 - 6,523,370 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,460,486 - 6,489,951 (+)NCBI
Rac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,491,236 - 143,513,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,489,389 - 143,513,791 (-)EnsemblGRCm39 Ensembl
GRCm385143,505,481 - 143,528,031 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,503,634 - 143,528,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv375144,266,349 - 144,288,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,761,100 - 143,783,611 (-)NCBIMGSCv36mm8
Celera5140,552,192 - 140,574,740 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.22NCBI
Rac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,150,411 - 16,170,864 (+)NCBIGRCr8
mRatBN7.21211,037,028 - 11,057,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,844,100 - 11,864,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,467,387 - 12,487,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,647 - 11,513,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
Rac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,270,159 - 13,311,351 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,270,159 - 13,295,562 (-)NCBIChiLan1.0ChiLan1.0
RAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,267,125 - 11,296,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,591,833 - 59,621,373 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v077,039,379 - 7,068,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,559,590 - 6,599,814 (+)NCBIpanpan1.1PanPan1.1panPan2
RAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,726,259 - 11,758,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,655,494 - 11,757,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,358,080 - 13,382,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,733,309 - 11,759,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,733,323 - 11,759,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,609,365 - 11,633,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,589,106 - 11,613,379 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,817,075 - 11,841,312 (+)NCBIUU_Cfam_GSD_1.0
Rac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,822,631 - 139,837,571 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750107,689 - 122,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936750107,689 - 122,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,781,780 - 4,803,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,781,776 - 4,803,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Rac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474030,911,598 - 30,934,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474030,912,841 - 30,933,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015808   ⟹   ENSCSAP00000013736
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)Ensembl
RefSeq Acc Id: XM_008018730   ⟹   XP_008016921
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12815,583,636 - 15,610,753 (+)NCBI
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018731   ⟹   XP_008016922
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12815,583,609 - 15,610,753 (+)NCBI
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008016921 (Get FASTA)   NCBI Sequence Viewer  
  XP_008016922 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013736
  ENSCSAP00000013736.1
Reference Protein Sequences
RefSeq Acc Id: XP_008016922   ⟸   XM_008018731
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RYP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008016921   ⟸   XM_008018730
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000013736   ⟸   ENSCSAT00000015808


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017712 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015808.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
NCBI Gene RAC1 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9RYP7 ENTREZGENE, UniProtKB/TrEMBL