Prkce Rat Gene (protein kinase C, epsilon)

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Keyword

Gene:
Prkce ( Rattus norvegicus )
protein kinase C, epsilon
Description: has phospholipid and diacylglycerol-dependent activity; plays a role in ouabain induced Na+/K+-ATPase mediated signal transduction in cardiac myocytes
Synonyms: Pkce;
ArrayIDs: M18331_at; 1374593_at; rc_AA799421_at; M18331_g_at; M15523_s_at;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: PRKCE     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Prkce     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Prkce Rat Celera Assembly 6 7696161 - 8179565
RGSC genome assembly v3.4 6 9631243 - 10097311
Cytogenetic 6 q12
genome assembly 3.1 6 9631241 - 10097311
Mus musculus Prkce Mouse genome assembly build 36.1 17 86567930 - 87054038
Cytogenetic 17 17 E4
Homo sapiens PRKCE human genome assembly 2 45790693 - 46326779
Human genome assembly build 36.2 2 45732547 - 46268633
Cytogenetic 2 p21

View comparative maps:      NCBI MapViewer

Genome
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Browsers:

Annotation
Molecular Function

Gene Ontology

zinc ion binding,  nucleotide binding,  protein serine/threonine kinase activity ... (details...)
Biological Process

Gene Ontology

protein amino acid phosphorylation,  regulation of peptidyl-tyrosine phosphorylation,  intracellular signaling cascade (details...)
Cellular Component

Gene Ontology

nucleus,  cytoplasm,  plasma membrane (details...)
Disease

Ontology

Hypertension,  Cardiomegaly (details...)
Regulation

Note Reference

628493

Drugs

Note Reference

activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 628493

External Links
Databases
DATABASE ID SOURCE
SMART: S_TKc IPI
SMART: S_TK_X IPI
SMART: C1 IPI
SMART: C2 IPI
PROSITE: PROTEIN_KINASE_ATP IPI
PROSITE: PROTEIN_KINASE_DOM IPI
PROSITE: PROTEIN_KINASE_ST IPI
PROSITE: C2 IPI
PROSITE: AGC_KINASE_CTER IPI
PROSITE: ZF_DAG_PE_1 IPI
PROSITE: ZF_DAG_PE_2 IPI
UNIPARC: UPI000012DF6D IPI
UNIPARC: UPI00000E662B IPI
KEGG Report: rno:29340 ENTREZGENE
HomoloGene Group ID: 48343 ENTREZGENE
Germonline: 61925
Pfam: Pkinase_C IPI
Pfam: Pkinase IPI
Pfam: C2 IPI
Pfam: C1_1 IPI
KEGG Pathway: 04930 ENTREZGENE
KEGG Pathway: 04664 ENTREZGENE
KEGG Pathway: 04530 ENTREZGENE
InterPro: Ser/Thr_prot_kinase_AS. IPI
InterPro: Se/Thr_prot_kinase-like_dom. IPI
InterPro: Protein_kinase_ATP_BS. IPI
InterPro: Prot_kinase_cat_dom. IPI
InterPro: PKC. IPI
InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI
InterPro: AGC-kinase_C. IPI
InterPro: C2_Ca-dep. IPI
InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI
InterPro: C2_membr_targeting. IPI
InterPro: DAG/PE_bd. IPI
InterPro: Pkinase_C. IPI
InterPro: Prot_kin_PKC_delta. IPI
InterPro: Kinase-like_dom. IPI
InterPro: Ser/Thr_prot_kinase_dom. IPI
Ensembl Protein: ENSRNOP00000020959 IPI
IPI: IPI00209019 IPI
IPI: IPI00551781 IPI
Entrez Gene: Prkce ENTREZGENE
PIRSF: PKC_delta IPI
Ensembl Genes: ENSRNOG00000015603 IPI
UniProt: Q63432_RAT IPI
UniProt: Q6DUV1_RAT IPI
UniProt: KPCE_RAT IPI
Superfamily-SCOP: C2_CaLB IPI
Superfamily-SCOP: Kinase_like IPI
PANTHER: PKC IPI
BIND: 133998
PRINTS: DAGPEDOMAIN. IPI
Sequences
Nucleotide: M18331 Get FASTA Search GEO Profiles
Nucleotide: M15523 Get FASTA Search GEO Profiles
Nucleotide: AY642593 Get FASTA Search GEO Profiles
Nucleotide: CH473947 Get FASTA Search GEO Profiles
Nucleotide: NM_017171 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: Q6DUV1 Get FASTA
Protein: Q63432 Get FASTA
Protein: P09216 Get FASTA
Protein: AAA41872 Get FASTA
Protein: AAA41877 Get FASTA
Protein: AAT65503 Get FASTA
Protein: EDM02661 Get FASTA
Protein: NP_058867 Get FASTA
(View all 8 Protein Accessions)
Clusters
UniGene: 216481

References
Curated References
9 references in RGD related to Prkce

Other References
105 other references at PubMed related to Prkce

Database Information
RGD ID 61925
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-JUN-02: Prkce protein kinase C, epsilon APPROVED Name updated 70584

12-DEC-01: Prkce protein kinase C, epsilon APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 69665

10-DEC-01: Prkce protein kinase C, epsilon WITHDRAWN --select from list or type below-- 69665