Prkce (protein kinase C epsilon) - Rat Genome Database

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Pathways
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Gene: Prkce (protein kinase C epsilon) Ictidomys tridecemlineatus
Analyze
Symbol: Prkce
Name: protein kinase C epsilon
RGD ID: 12477271
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN cell-substrate adhesion (ortholog); cellular response to ethanol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); cardiomyopathy (ortholog); Colorectal Neoplasms (ortholog); FOUND IN glutamatergic synapse (ortholog); Golgi membrane (ortholog); neuromuscular junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,589,765 - 35,066,607 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365086,017,551 - 6,494,427 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365086,018,374 - 6,495,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
cell division  (IEA)
cell-substrate adhesion  (IEA,ISO)
cellular response to ethanol  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
insulin secretion  (IEA,ISO)
intracellular signal transduction  (ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
locomotory exploration behavior  (IEA,ISO)
macrophage activation involved in immune response  (IEA,ISO)
MAPK cascade  (IEA,ISO)
mucus secretion  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of mitochondrial calcium ion concentration  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
negative regulation of protein ubiquitination  (IEA)
negative regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of actin filament polymerization  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell-substrate adhesion  (IEA,ISO)
positive regulation of cellular glucuronidation  (IEA)
positive regulation of cytokinesis  (IEA)
positive regulation of epithelial cell migration  (IEA)
positive regulation of fibroblast migration  (IEA)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of lipid catabolic process  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mucus secretion  (IEA,ISO)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO)
positive regulation of wound healing  (IEA)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
regulation of lipid metabolic process  (IEA,ISO)
regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
response to morphine  (IEA,ISO)
synaptic transmission, GABAergic  (IEA,ISO)
TRAM-dependent toll-like receptor 4 signaling pathway  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,589,765 - 35,066,607 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365086,017,551 - 6,494,427 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365086,018,374 - 6,495,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38245,651,279 - 46,187,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl245,651,345 - 46,187,990 (+)EnsemblGRCh38hg38GRCh38
GRCh37245,878,814 - 46,415,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,732,547 - 46,268,633 (+)NCBINCBI36Build 36hg18NCBI36
Build 34245,790,693 - 46,326,779NCBI
Celera245,717,245 - 46,253,470 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef245,617,217 - 46,153,158 (+)NCBIHuRef
CHM1_1245,810,047 - 46,345,904 (+)NCBICHM1_1
T2T-CHM13v2.0245,656,327 - 46,193,193 (+)NCBIT2T-CHM13v2.0
Prkce
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391786,472,631 - 86,965,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1786,475,213 - 86,965,347 (+)EnsemblGRCm39 Ensembl
GRCm381786,167,785 - 86,657,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,167,785 - 86,657,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv371786,567,125 - 87,057,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361786,076,916 - 86,563,024 (+)NCBIMGSCv36mm8
Celera1790,540,474 - 91,038,578 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.74NCBI
Prkce
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,718,050 - 14,204,931 (-)NCBIGRCr8
mRatBN7.267,965,048 - 8,451,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,965,048 - 8,451,719 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx68,241,962 - 8,728,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,551,358 - 9,037,685 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.068,078,663 - 8,564,995 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.069,483,400 - 9,973,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.069,404,548 - 9,883,579 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.469,631,234 - 10,097,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.169,631,241 - 10,097,311 (+)NCBI
Celera67,696,161 - 8,179,574 (-)NCBICelera
Cytogenetic Map6q12NCBI
Prkce
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544112,642,697 - 13,139,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544112,642,703 - 13,142,396 (+)NCBIChiLan1.0ChiLan1.0
PRKCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21280,214,185 - 80,750,763 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A80,218,154 - 80,754,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A45,757,629 - 46,294,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A46,688,109 - 47,223,421 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A46,688,436 - 47,220,313 (+)Ensemblpanpan1.1panPan2
PRKCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11047,976,929 - 48,464,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1047,976,768 - 48,535,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1047,832,146 - 48,319,423 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01048,849,986 - 49,335,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1048,849,926 - 49,335,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11048,557,609 - 49,044,861 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01048,849,404 - 49,334,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,029,809 - 49,517,384 (+)NCBIUU_Cfam_GSD_1.0
PRKCE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl394,349,889 - 94,866,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,351,277 - 94,864,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,427,723 - 100,762,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11461,022,903 - 61,570,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1461,026,017 - 61,242,343 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604550,297,930 - 50,835,743 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkce
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473827,118,145 - 27,627,606 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473827,118,764 - 27,630,733 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000012617   ⟹   ENSSTOP00000011308
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365086,017,551 - 6,494,427 (-)Ensembl
RefSeq Acc Id: XM_005324505   ⟹   XP_005324562
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629234,589,765 - 35,065,952 (-)NCBI
SpeTri2.0NW_0049365086,018,374 - 6,494,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725839   ⟹   XP_021581514
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629234,610,822 - 35,066,607 (-)NCBI
SpeTri2.0NW_0049365086,039,431 - 6,495,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725840   ⟹   XP_021581515
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629234,589,765 - 34,918,108 (-)NCBI
SpeTri2.0NW_0049365086,018,374 - 6,346,838 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040270970   ⟹   XP_040126904
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629234,589,765 - 34,892,378 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005324562   ⟸   XM_005324505
- Peptide Label: isoform X1
- UniProtKB: I3MJI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581515   ⟸   XM_021725840
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021581514   ⟸   XM_021725839
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040126904   ⟸   XM_040270970
- Peptide Label: isoform X4
RefSeq Acc Id: ENSSTOP00000011308   ⟸   ENSSTOT00000012617
Protein Domains
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012596 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012617.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  nPKC_epsilon UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PKC_epsilon UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Prkce ENTREZGENE
PANTHER PROTEIN KINASE C EPSILON TYPE UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF PKC_delta UniProtKB/TrEMBL
  Protein_kin_C_epsilon UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt I3MJI3 ENTREZGENE, UniProtKB/TrEMBL