Timp2 (TIMP metallopeptidase inhibitor 2) - Rat Genome Database

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Gene: Timp2 (TIMP metallopeptidase inhibitor 2) Rattus norvegicus
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Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
RGD ID: 61312
Description: Enables integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including negative regulation of proteolysis; positive regulation of neuron differentiation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2); INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metalloproteinase inhibitor 2; MGC105282; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810104,041,604 - 104,089,214 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10104,041,604 - 104,089,214 (-)EnsemblGRCr8
mRatBN7.210103,541,199 - 103,590,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,531,505 - 103,590,611 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,643,337 - 108,691,010 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010108,106,467 - 108,154,150 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,463,707 - 103,511,317 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10102,103,187 - 102,150,797 (-)NCBICelera
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3,4-dihydrocoumarin  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ambroxol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
batimastat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betulin  (EXP)
betulinic acid  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
calcitriol  (ISO)
candesartan  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
chloroquine  (ISO)
choline  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DAPT  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
fenofibrate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gallic acid  (EXP)
Geniposide pentaacetate  (EXP)
genistein  (ISO)
glucose  (ISO)
Gly-His-Lys  (EXP)
graphene oxide  (ISO)
HET0016  (ISO)
hexachlorobenzene  (EXP)
hinokiflavone  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
indinavir  (ISO)
indometacin  (EXP)
inulin  (ISO)
Isoangustone A  (ISO)
juglone  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
LY294002  (ISO)
melatonin  (EXP)
menadione  (ISO)
mesalamine  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylphenidate  (EXP)
metoprolol  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
naproxen  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
NORCANTHARIDIN  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oroxylin A  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
plumbagin  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prazosin  (EXP)
progesterone  (ISO)
propanal  (ISO)
propofol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
Shikonin  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
solasodine  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
Ulipristal  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
3. Cardiac remodeling after long term norepinephrine treatment in rats. Briest W, etal., Cardiovasc Res 2001 Nov;52(2):265-73.
4. Cloning and regulation of rat tissue inhibitor of metalloproteinases-2 in osteoblastic cells. Cook TF, etal., Arch Biochem Biophys 1994 Jun;311(2):313-20.
5. Cellular localization of tissue inhibitors of metalloproteinases in the rat ovary throughout pseudopregnancy. Curry TE Jr and Wheeler SE, Biol Reprod 2002 Dec;67(6):1943-51.
6. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
7. Effect of losartan on the mRNA expressions of MT3-MMP and TIMP-2 in diabetic kidneys. Ding HL, etal., Rev Diabet Stud. 2005 Winter;2(4):216-20. Epub 2006 Feb 10.
8. Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
9. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
10. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes.] Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury. Gipson TS, etal., J Immunol. 1999 Mar 15;162(6):3653-62.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
15. Purification, cDNA cloning, and developmental changes in the steady-state mRNA level of rat testicular tissue inhibitor of metalloproteases-2 (TIMP-2). Grima J, etal., J Androl 1996 May-Jun;17(3):263-75.
16. Osteoblasts and osteocytes express MMP2 and -8 and TIMP1, -2, and -3 along with extracellular matrix molecules during appositional bone formation. Hatori K, etal., Anat Rec A Discov Mol Cell Evol Biol 2004 Apr;277(2):262-71.
17. Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats. Hu YB, etal., J Gene Med. 2007 Mar;9(3):217-29.
18. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
19. Differential regulation of tissue inhibitor of metalloproteinase mRNA expression in response to intracranial injury. Jaworski DM Glia. 2000 Apr;30(2):199-208.
20. Serum levels of matrix metalloproteinases MMP-2 and MMP-9 and their tissue natural inhibitors in breast tumors. Jinga D, etal., Roum Arch Microbiol Immunol. 2004 Jul-Dec;63(3-4):141-58.
21. Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease. Kang HS, etal., Neurosurgery. 2006 Jun;58(6):1074-80; discussion 1074-80.
22. Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
23. Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model: role of pro-inflammatory cytokines. Krizanac-Bengez L, etal., Am J Physiol Cell Physiol. 2006 Oct;291(4):C740-9. Epub 2006 May 17.
24. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
25. The roles of MMP-2/TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats. Li Q, etal., Acta Cardiol. 2007 Oct;62(5):485-91.
26. Evidence that MMP-2 and TIMP-2 are at play in the FSH-induced changes in Sertoli cells. Longin J and Le Magueresse-Battistoni B, Mol Cell Endocrinol 2002 Mar 28;189(1-2):25-35.
27. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Lorenzl S, etal., J Neurol Sci. 2003 Mar 15;207(1-2):71-6.
28. MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Mendes O, etal., Clin Exp Metastasis. 2007;24(5):341-51. Epub 2007 May 16.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Expression of TIMP-1 and TIMP-2 in rats with hepatic fibrosis. Nie QH, etal., World J Gastroenterol. 2004 Jan;10(1):86-90.
32. Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction. Noji Y, etal., Circ J. 2004 Apr;68(4):355-60.
33. Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
34. Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal. Perez-Martinez L and Jaworski DM, J Neurosci. 2005 May 18;25(20):4917-29.
35. Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors. Pulukuri SM, etal., Oncogene. 2007 Aug 9;26(36):5229-37. Epub 2007 Feb 26.
36. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
40. Cloning of the rat tissue inhibitor of metalloproteinases type 2 (TIMP-2) gene: analysis of its expression in normal and transformed thyroid cells. Santoro M, etal., Exp Cell Res 1994 Aug;213(2):398-403.
41. Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3-sensitive proteolysis. Shuo T, etal., J Neurochem. 2007 Sep;102(5):1561-8. Epub 2007 May 26.
42. Expression of matrix metalloproteases (MMP-2, MT1 -MMP) and their tissue inhibitor (TIMP-2) by rat sertoli cells in culture: implications for spermatogenesis. Slongo ML, etal., Biol Chem 2002 Jan;383(1):235-9.
43. Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
44. [mRNA expression analysis of metastatic markers in clear-cell renal cell carcinoma] Struckmann K, etal., Verh Dtsch Ges Pathol. 2005;89:178-83.
45. Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats. Takahashi I, etal., J Mol Histol. 2005 Jun;36(5):355-66. Epub 2005 Oct 6.
46. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Trudel D, etal., Hum Pathol. 2008 Mar 7;.
47. Serum tissue inhibitor of metalloproteinase-2 (TIMP-2) and matrix metalloproteinase-2 in complex with the inhibitor (MMP-2:TIMP-2) as prognostic markers in bladder cancer. Vasala K and Turpeenniemi-Hujanen T, Clin Biochem. 2007 Jun;40(9-10):640-4. Epub 2007 Feb 8.
48. Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy. von Moers A, etal., Acta Neuropathol (Berl). 2005 Mar;109(3):285-93. Epub 2004 Dec 23.
49. [Effect of interferon-gamma on transforming growth factor beta/Smad signal pathway and expression of matrix metalloproteinase-2 and tissue inhibitors of matrix metalloproteinase-2 in cultured rat mesangial cells] Xue AM, etal., Zhonghua Bing Li Xue Za Zhi. 2007 Jun;36(6):405-9.
50. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
51. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Zhao YG, etal., Cancer Res. 2004 Jan 15;64(2):590-8.
52. Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Zhao YG, etal., Mol Reprod Dev 2002 Jun;62(2):149-58.
53. [Changes of matrix metalloproteinase 2,9 and tissue inhibitor of metalloproteinase 1, 2, 3 expression level in aged rat lung.] Zhao ZJ, etal., Beijing Da Xue Xue Bao. 2008 Feb 18;40(1):101-104.
Additional References at PubMed
PMID:1309971   PMID:9573338   PMID:10827175   PMID:10827176   PMID:11869290   PMID:12477932   PMID:12950084   PMID:12970340   PMID:15489334   PMID:18000599   PMID:18415800   PMID:18558556  
PMID:18675881   PMID:18935914   PMID:18983773   PMID:19184368   PMID:20103929   PMID:20226641   PMID:21141515   PMID:21782897   PMID:22045123   PMID:22092673   PMID:22110735   PMID:22974613  
PMID:23376485   PMID:23383440   PMID:23886643   PMID:23979707   PMID:24006456   PMID:24073280   PMID:24685074   PMID:24970341   PMID:25028660   PMID:26047379   PMID:26258010   PMID:26601648  
PMID:27322513   PMID:27323108   PMID:29075637   PMID:29302675   PMID:29308554   PMID:29955613   PMID:31392726   PMID:34830409  


Genomics

Comparative Map Data
Timp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810104,041,604 - 104,089,214 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10104,041,604 - 104,089,214 (-)EnsemblGRCr8
mRatBN7.210103,541,199 - 103,590,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,531,505 - 103,590,611 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,643,337 - 108,691,010 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010108,106,467 - 108,154,150 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,463,707 - 103,511,317 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10102,103,187 - 102,150,797 (-)NCBICelera
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Cytogenetic Map10q32.3NCBI
TIMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,852,977 - 78,925,387 (-)Ensemblhg38GRCh38
GRCh371776,849,059 - 76,921,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
T2T-CHM13v2.01779,747,776 - 79,820,220 (-)NCBIT2T-CHM13v2.0
Timp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,191,887 - 118,246,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11118,191,887 - 118,246,566 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,301,069 - 118,355,740 (-)Ensemblmm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBIMGSCv36mm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.09NCBI
Timp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)Ensembl
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBIChiLan1.0ChiLan1.0
TIMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,901,178 - 94,974,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,731,234 - 99,804,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,928,692 - 73,001,892 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11778,476,807 - 78,495,885 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1778,476,807 - 78,495,649 (-)EnsemblpanPan2panpan1.1
TIMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,521,882 - 2,533,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha93,146,850 - 3,191,997 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.093,140,666 - 3,188,540 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.193,162,992 - 3,208,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,288,768 - 3,333,886 (+)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.093,301,440 - 3,310,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,369,678 - 3,414,817 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Timp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,160,813 - 3,179,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365943,232,355 - 3,244,241 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365943,232,433 - 3,244,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,254,493 - 3,300,834 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1123,254,794 - 3,300,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,294,254 - 3,340,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,819,591 - 70,850,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,819,139 - 70,850,471 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607741,956,134 - 42,029,058 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248018,228,357 - 8,270,982 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248018,228,618 - 8,270,606 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Timp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1965,703,117 - 65,752,768 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Timp2
291 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:191
Interacting mature miRNAs:216
Transcripts:ENSRNOT00000004290
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
Timp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,590,354 - 103,590,484 (+)MAPPERmRatBN7.2
Rnor_6.010107,385,816 - 107,385,945NCBIRnor6.0
Rnor_5.010107,020,814 - 107,020,943UniSTSRnor5.0
Celera10102,150,541 - 102,150,670UniSTS
Cytogenetic Map10q32.3UniSTS
Ddc8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,568,065 - 103,568,480 (+)MAPPERmRatBN7.2
Rnor_6.010107,363,534 - 107,363,948NCBIRnor6.0
Rnor_5.010106,998,532 - 106,998,946UniSTSRnor5.0
Celera10102,128,259 - 102,128,673UniSTS
Cytogenetic Map10q32.3UniSTS
Timp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,553,466 - 103,553,573 (+)MAPPERmRatBN7.2
Rnor_6.010107,348,935 - 107,349,041NCBIRnor6.0
Rnor_5.010106,983,933 - 106,984,039UniSTSRnor5.0
Celera10102,113,660 - 102,113,766UniSTS
Cytogenetic Map10q32.3UniSTS
Timp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,556,030 - 103,556,135 (+)MAPPERmRatBN7.2
Rnor_6.010107,351,499 - 107,351,603NCBIRnor6.0
Rnor_5.010106,986,497 - 106,986,601UniSTSRnor5.0
Celera10102,116,224 - 102,116,328UniSTS
Cytogenetic Map10q32.3UniSTS
Timp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,545,903 - 103,546,023 (+)MAPPERmRatBN7.2
mRatBN7.23163,247,412 - 163,248,931 (+)MAPPERmRatBN7.2
Rnor_6.010107,341,373 - 107,341,492NCBIRnor6.0
Rnor_6.03172,549,698 - 172,551,216NCBIRnor6.0
Rnor_5.010106,976,371 - 106,976,490UniSTSRnor5.0
Rnor_5.03178,596,824 - 178,598,342UniSTSRnor5.0
Celera10102,106,097 - 102,106,216UniSTS
Celera3162,420,887 - 162,422,405UniSTS
Cytogenetic Map10q32.3UniSTS
Timp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,543,868 - 103,544,040 (+)MAPPERmRatBN7.2
Rnor_6.010107,339,340 - 107,339,511NCBIRnor6.0
Rnor_5.010106,974,338 - 106,974,509UniSTSRnor5.0
Celera10102,104,062 - 102,104,233UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ409332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S82718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004290   ⟹   ENSRNOP00000004290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10104,041,604 - 104,089,214 (-)Ensembl
mRatBN7.2 Ensembl10103,542,994 - 103,590,611 (-)Ensembl
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046213   ⟹   ENSRNOP00000043063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10104,064,545 - 104,084,291 (-)Ensembl
mRatBN7.2 Ensembl10103,567,973 - 103,581,747 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097016   ⟹   ENSRNOP00000088520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,567,973 - 103,580,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104887   ⟹   ENSRNOP00000086221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,531,505 - 103,580,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105725   ⟹   ENSRNOP00000087019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,567,973 - 103,580,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118911   ⟹   ENSRNOP00000096720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10104,054,640 - 104,068,504 (-)Ensembl
mRatBN7.2 Ensembl10103,563,736 - 103,590,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119828   ⟹   ENSRNOP00000086076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,567,973 - 103,580,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123373   ⟹   ENSRNOP00000111326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10104,041,604 - 104,074,768 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140857   ⟹   ENSRNOP00000100507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10104,064,545 - 104,084,291 (-)Ensembl
RefSeq Acc Id: NM_021989   ⟹   NP_068824
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,041,604 - 104,089,214 (-)NCBI
mRatBN7.210103,542,994 - 103,590,611 (-)NCBI
Rnor_6.010107,338,465 - 107,386,072 (-)NCBI
Rnor_5.010106,973,463 - 107,021,070 (-)NCBI
RGSC_v3.410108,310,473 - 108,358,821 (-)RGD
Celera10102,103,187 - 102,150,797 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085773   ⟹   XP_038941701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,042,364 - 104,076,570 (-)NCBI
mRatBN7.210103,541,199 - 103,577,752 (-)NCBI
RefSeq Acc Id: XM_063268830   ⟹   XP_063124900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,088,652 (-)NCBI
RefSeq Acc Id: XM_063268831   ⟹   XP_063124901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,075,528 (-)NCBI
RefSeq Acc Id: XM_063268832   ⟹   XP_063124902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,088,652 (-)NCBI
RefSeq Acc Id: XM_063268833   ⟹   XP_063124903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,088,652 (-)NCBI
RefSeq Acc Id: XM_063268834   ⟹   XP_063124904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,088,652 (-)NCBI
RefSeq Acc Id: XM_063268835   ⟹   XP_063124905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,088,652 (-)NCBI
RefSeq Acc Id: XM_063268836   ⟹   XP_063124906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,076,115 (-)NCBI
RefSeq Acc Id: XM_063268837   ⟹   XP_063124907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,066,652 - 104,088,652 (-)NCBI
RefSeq Acc Id: XM_063268838   ⟹   XP_063124908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,042,364 - 104,074,702 (-)NCBI
RefSeq Acc Id: XM_063268839   ⟹   XP_063124909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,042,364 - 104,076,550 (-)NCBI
RefSeq Acc Id: XM_063268840   ⟹   XP_063124910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,042,364 - 104,076,271 (-)NCBI
RefSeq Acc Id: XM_063268841   ⟹   XP_063124911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810104,042,364 - 104,076,550 (-)NCBI
RefSeq Acc Id: NP_068824   ⟸   NM_021989
- Peptide Label: precursor
- UniProtKB: Q546J4 (UniProtKB/Swiss-Prot),   P30121 (UniProtKB/Swiss-Prot),   A6HL48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004290   ⟸   ENSRNOT00000004290
RefSeq Acc Id: XP_038941701   ⟸   XM_039085773
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000087019   ⟸   ENSRNOT00000105725
Ensembl Acc Id: ENSRNOP00000088520   ⟸   ENSRNOT00000097016
Ensembl Acc Id: ENSRNOP00000086221   ⟸   ENSRNOT00000104887
Ensembl Acc Id: ENSRNOP00000043063   ⟸   ENSRNOT00000046213
Ensembl Acc Id: ENSRNOP00000086076   ⟸   ENSRNOT00000119828
Ensembl Acc Id: ENSRNOP00000096720   ⟸   ENSRNOT00000118911
RefSeq Acc Id: XP_063124909   ⟸   XM_063268839
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063124911   ⟸   XM_063268841
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063124910   ⟸   XM_063268840
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063124908   ⟸   XM_063268838
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A3D8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124900   ⟸   XM_063268830
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124907   ⟸   XM_063268837
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124904   ⟸   XM_063268834
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124903   ⟸   XM_063268833
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124902   ⟸   XM_063268832
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124905   ⟸   XM_063268835
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124906   ⟸   XM_063268836
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124901   ⟸   XM_063268831
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100507   ⟸   ENSRNOT00000140857
Ensembl Acc Id: ENSRNOP00000111326   ⟸   ENSRNOT00000123373
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30121-F1-model_v2 AlphaFold P30121 1-220 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61312 AgrOrtholog
BioCyc Gene G2FUF-22519 BioCyc
Ensembl Genes ENSRNOG00000003148 Ensembl
  ENSRNOG00000033143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000089169 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004290 ENTREZGENE
  ENSRNOT00000004290.5 UniProtKB/Swiss-Prot
  ENSRNOT00000123373 ENTREZGENE
  ENSRNOT00000140857 ENTREZGENE
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7303706 IMAGE-MGC_LOAD
InterPro Netrin_domain UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
  TIMP_C UniProtKB/Swiss-Prot
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report rno:29543 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105282 IMAGE-MGC_LOAD
NCBI Gene 29543 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF24 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot
PhenoGen Timp2 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003148 RatGTEx
  ENSRNOG00000033143 RatGTEx
  ENSRNOG00000089169 RatGTEx
SMART NTR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
UniProt A0A8I6A3D8 ENTREZGENE
  A0ABK0M2Y4_RAT UniProtKB/TrEMBL
  A6HL48 ENTREZGENE, UniProtKB/TrEMBL
  P30121 ENTREZGENE
  Q546J4 ENTREZGENE
  TIMP2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q546J4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Timp2  TIMP metallopeptidase inhibitor 2  Timp2  tissue inhibitor of metalloproteinase 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Timp2  tissue inhibitor of metalloproteinase 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis Sertoli and Leydig cells 730126