Timp2 (TIMP metallopeptidase inhibitor 2) - Rat Genome Database

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Gene: Timp2 (TIMP metallopeptidase inhibitor 2) Chinchilla lanigera
Analyze
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
RGD ID: 9010106
Description: ENCODES a protein that exhibits enzyme activator activity (ortholog); integrin binding (ortholog); metalloendopeptidase inhibitor activity (ortholog); INVOLVED IN cellular response to organic substance (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of mitotic cell cycle (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); Brain Injuries (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metalloproteinase inhibitor 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Timp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBIChiLan1.0ChiLan1.0
TIMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,852,977 - 78,925,387 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,849,059 - 76,921,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
T2T-CHM13v2.01779,747,776 - 79,820,220 (-)NCBIT2T-CHM13v2.0
Timp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,191,887 - 118,246,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11118,191,887 - 118,246,566 (-)EnsemblGRCm39 Ensembl
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,301,069 - 118,355,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBIMGSCv36mm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.09NCBI
Timp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810104,041,604 - 104,089,214 (-)NCBIGRCr8
mRatBN7.210103,541,199 - 103,590,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,531,505 - 103,590,611 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,643,337 - 108,691,010 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010108,106,467 - 108,154,150 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,463,707 - 103,511,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Celera10102,103,187 - 102,150,797 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
TIMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,901,178 - 94,974,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,731,234 - 99,804,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,928,692 - 73,001,892 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11778,476,807 - 78,495,885 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1778,476,807 - 78,495,649 (-)Ensemblpanpan1.1panPan2
TIMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,521,882 - 2,533,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha93,146,850 - 3,191,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,140,666 - 3,188,540 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.193,162,992 - 3,208,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,288,768 - 3,333,886 (+)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.093,301,440 - 3,310,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,369,678 - 3,414,817 (+)NCBIUU_Cfam_GSD_1.0
Timp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,160,813 - 3,179,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365943,232,355 - 3,244,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365943,232,433 - 3,244,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,254,493 - 3,300,834 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,254,794 - 3,300,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,294,254 - 3,340,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,819,591 - 70,850,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,819,139 - 70,850,471 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,956,134 - 42,029,058 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248018,228,357 - 8,270,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248018,228,618 - 8,270,606 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000016576   ⟹   ENSCLAP00000016412
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)Ensembl
RefSeq Acc Id: XM_005407364   ⟹   XP_005407421
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005407421 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016412
  ENSCLAP00000016412.1
Reference Protein Sequences
RefSeq Acc Id: XP_005407421   ⟸   XM_005407364
- UniProtKB: A0A8C2VN79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000016412   ⟸   ENSCLAT00000016576
Protein Domains
NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011284 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016576 ENTREZGENE
  ENSCLAT00000016576.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
  TIMP_C UniProtKB/TrEMBL
  TIMP_CS UniProtKB/TrEMBL
NCBI Gene LOC102029096 ENTREZGENE
PANTHER PTHR11844 UniProtKB/TrEMBL
  PTHR11844:SF24 UniProtKB/TrEMBL
Pfam TIMP UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
SMART NTR UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
UniProt A0A8C2VN79 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Timp2  TIMP metallopeptidase inhibitor 2  LOC102029096  metalloproteinase inhibitor 2-like  Symbol and/or name change 5135510 APPROVED