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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61312
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp2increases expressionISOTIMP2 (Homo sapiens)6480464CTDGlucose results in increased expression of TIMP2 proteinPMID:21367880
Timp2multiple interactionsISOTIMP2 (Homo sapiens)6480464CTD[Glucose co-treated with Air Pollutants] results in decreased expression of TIMP2 mRNA; [Glucose co-treated with Particulate Matter] results in decreased expression of TIMP2 mRNA; isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]PMID:21367880 PMID:26179980
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