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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61312
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp2increases acetylationISOTIMP2 (Homo sapiens)6480464CTDochratoxin A results in increased acetylation of TIMP2 promoterPMID:29098329
Timp2increases expressionISOTIMP2 (Homo sapiens)6480464CTDochratoxin A results in increased expression of TIMP2 mRNAPMID:29098329
Timp2multiple interactionsISOTimp2 (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of TIMP2 mRNAPMID:28710020
Timp2multiple interactionsISOTIMP2 (Homo sapiens)6480464CTD[ochratoxin A results in increased acetylation of TIMP2 promoter] which results in increased expression of TIMP2 mRNAPMID:29098329
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