GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Timp2 | decreases expression | ISO | TIMP2 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of TIMP2 mRNA; Estradiol results in decreased expression of TIMP2 protein | PMID:19167446 PMID:19956873 PMID:33631300 | Timp2 | multiple interactions | ISO | TIMP2 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]; [Estradiol co-treated with Norethindrone Acetate] results in increased expression of TIMP2 mRNA; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein] | PMID:19956873 PMID:22217510 | | ||||||||||||||||||||||
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