Gene:	Prkcz ( Rattus norvegicus ) protein kinase C, zeta
Description:	atypical protein kinase C which participates in the insulin, neuregulin and angiotensin II signaling pathways; involved in insulin resistance via regulation of glucose import into muscle cells and in long term memory via regulation of long-term potentiation
Synonyms:	14 - 3 - 3 - zeta isoform; r14-3-3; Pkcz; 14-3-3-zetaisoform;
ArrayIDs:	6354957; 1370197_a_at; 5973179; J04532_at; 6197226; 6031957; 6679958; 6549921; M18332_s_at; 5861983; 6175967; 6715974; 6415008; 6442725; 6011659; 5803344; 6188161; A_44_P406474; 5816890; 5777573; 6086087; 6245751; 6269789;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PRKCZ     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Prkcz     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Prkcz genome assembly 3.1 5 172072319 - 172179534     Rat Celera Assembly 5 164023257 - 164132959     RGSC genome assembly v3.4 5 172061825 - 172172793     Cytogenetic 5 q36 Mus musculus Prkcz Mouse genome assembly build 36.1 4 154634229 - 154735500     Cytogenetic 4 4 E2 Homo sapiens PRKCZ human genome assembly 1 2014070 - 2148996     Human genome assembly build 36.2 1 1971769 - 2106694     Cytogenetic 1 p36.33-p36.2   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology zinc ion binding,  protein kinase activity,  protein kinase binding ...  (details...)
Biological Process	Note Reference mediates basal and IGF-1-dependent mitogenesis 61695, 70640 enhances PDX-1 transcription factor binding activity after stimulation of IGF-1 in RIN 1046-38 cells 61695, 70640 Gene Ontology vesicle transport along microtubule,  positive regulation of cell proliferation,  negative regulation of insulin receptor signaling pathway ...  (details...)
Cellular Component	Gene Ontology tight junction,  membrane raft,  cytoplasm ...  (details...)
Disease	Ontology Hypertrophy, Left Ventricular,  Insulin Resistance,  Hyperglycemia (details...)
Phenotype	Ontology enhanced long term potentiation,  abnormal conditioned taste aversion behavior,  hyperglycemia ...  (details...)
Expression	Note Reference expressed in pancreatic islets 70640
Pathway	Ontology vascular endothelial growth factor signaling pathway,  epidermal growth factor/neuregulin signaling pathway,  Angiotensin II signaling pathway ...  (details...)
Regulation	Note Reference induced by IL-1 and TNF-alpha; calcium- and diacylglycerol-insensitive 729628
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI SMART: S_TK_X IPI SMART: PB1 IPI SMART: C1 IPI PROSITE: ZF_DAG_PE_2 IPI PROSITE: ZF_DAG_PE_1 IPI PROSITE: PROTEIN_KINASE_ST IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: AGC_KINASE_CTER IPI UNIPARC: UPI000012DF77 IPI UNIPARC: UPI000059E27F IPI KEGG Report: rno:25522 ENTREZGENE HomoloGene Group ID: 55681 ENTREZGENE Germonline: 3399 Pfam: PB1 IPI Pfam: Pkinase IPI Pfam: Pkinase_C IPI Pfam: C1_1 IPI KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04530 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04144 ENTREZGENE InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI InterPro: Pkinase_C. IPI InterPro: PKC_zeta. IPI InterPro: PKC. IPI InterPro: OPR_PB1. IPI InterPro: Kinase-like_dom. IPI InterPro: DAG/PE_bd. IPI InterPro: AGC-kinase_C. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI Ensembl Protein: ENSRNOP00000021285 IPI Ensembl Protein: ENSRNOP00000060633 IPI IPI: IPI00950364 IPI IPI: IPI00212818 IPI Entrez Gene: Prkcz ENTREZGENE PIRSF: PKC_zeta IPI Ensembl Genes: ENSRNOG00000015480 IPI UniProt: Q9JLP6_RAT IPI UniProt: KPCZ_RAT IPI RatMap: 41407 ENTREZGENE Superfamily-SCOP: Kinase_like IPI PANTHER: PKC IPI PRINTS: DAGPEDOMAIN. IPI
Sequences	Nucleotide: AF149215 Get FASTA Search GEO Profiles Nucleotide: M18332 Get FASTA Search GEO Profiles Nucleotide: J04532 Get FASTA Search GEO Profiles Nucleotide: CH473968 Get FASTA Search GEO Profiles Nucleotide: U27191 Get FASTA Search GEO Profiles Nucleotide: AF149214 Get FASTA Search GEO Profiles Nucleotide: AF149212 Get FASTA Search GEO Profiles Nucleotide: NM_022507 Get FASTA Search GEO Profiles (View all 8 Nucleotide Accessions) Protein: AAF68171 Get FASTA Protein: Q9JLP6 Get FASTA Protein: P09217 Get FASTA Protein: NP_071952 Get FASTA Protein: EDL81293 Get FASTA Protein: AAA41878 Get FASTA Protein: AAA41934 Get FASTA Protein: EDL81295 Get FASTA Protein: EDL81294 Get FASTA (View all 9 Protein Accessions)
Clusters	UniGene: 1109
References
Curated References	33 references in RGD related to Prkcz
Other References	80 other references at PubMed related to Prkcz
Database Information
RGD ID	3399
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 23-JUL-01: Prkcz 14 - 3 - 3 - zeta isoform WITHDRAWN Name withdrawn 67952