Nr4a2 (nuclear receptor subfamily 4, group A, member 2) - Rat Genome Database

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Gene: Nr4a2 (nuclear receptor subfamily 4, group A, member 2) Rattus norvegicus
Analyze
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
RGD ID: 3202
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; and retina development in camera-type eye. Acts upstream of or within response to inorganic substance and response to insecticide. Part of chromatin. Biomarker of Parkinsonism and epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear orphan receptor HZF-3; nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor subfamily 4 group A member 2 variant TINUR; nur related protein 1; NUR-related factor 1; Nurr1; orphan nuclear receptor NURR1; orphan receptor; regenerating liver nuclear receptor 1; RNR-1; RNR1; SL-322
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,098,739 - 62,115,926 (-)NCBIGRCr8
mRatBN7.2341,689,847 - 41,707,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,028,318 - 45,033,797 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,613,078 - 53,618,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,404,666 - 51,410,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,111,258 - 43,128,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0348,183,106 - 48,192,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4338,866,205 - 38,871,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1338,763,218 - 38,769,911 (-)NCBI
Celera339,783,304 - 39,788,777 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
Carnosol  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dabigatran  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diheptyl phthalate  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geraniol  (ISO)
glafenine  (ISO)
glutathione  (EXP)
glycidol  (EXP)
GW 1929  (EXP)
heroin  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP)
lithium hydride  (ISO)
lucanthone  (ISO)
maneb  (EXP)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
N(6)-butyryl-cAMP  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
PCB138  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phencyclidine  (ISO)
phenformin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picoxystrobin  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (ISO)
probenecid  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetradecane  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
torcetrapib  (ISO)
triacsin C  (ISO)
trichostatin A  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IEA,ISO)
cellular response to corticotropin-releasing hormone stimulus  (IBA,IEA,ISO,ISS)
cellular response to oxidative stress  (IEA,ISO)
central nervous system neuron differentiation  (IBA,IEA,ISO)
central nervous system projection neuron axonogenesis  (IEA,ISO)
cerebral cortex development  (IEP)
DNA-templated transcription  (ISO,ISS)
dopamine biosynthetic process  (IEA,ISO)
dopamine metabolic process  (ISO)
dopaminergic neuron differentiation  (IBA,IEA,ISO,ISS)
fat cell differentiation  (IEA,ISO,ISS)
gene expression  (ISO)
general adaptation syndrome  (IEA,ISO)
habenula development  (IEA,ISO)
intracellular receptor signaling pathway  (IEA)
learning or memory  (IMP)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nervous system development  (ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (ISO)
neuron maturation  (IEA,ISO)
neuron migration  (IEA,ISO)
obsolete cellular response to extracellular stimulus  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
post-embryonic development  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of respiratory gaseous exchange  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to amphetamine  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to inorganic substance  (IDA)
response to insecticide  (IDA)
retina development in camera-type eye  (IEP)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component
chromatin  (IDA)
cytoplasm  (IEA)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival. Barneda-Zahonero B, etal., J Biol Chem. 2012 Mar 30;287(14):11351-62. doi: 10.1074/jbc.M111.272427. Epub 2012 Jan 31.
2. Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory. Colón-Cesario WI, etal., Learn Mem. 2006 Nov-Dec;13(6):734-44. doi: 10.1101/lm.407706.
3. Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity. Eells JB, etal., PLoS One. 2015 Apr 9;10(4):e0119280. doi: 10.1371/journal.pone.0119280. eCollection 2015.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Green AL, etal., Neuropharmacology. 2017 Oct;125:189-196. doi: 10.1016/j.neuropharm.2017.07.020. Epub 2017 Jul 22.
7. Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. Kandil EA, etal., Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1141-1150. doi: 10.1111/1440-1681.13162. Epub 2019 Sep 9.
8. Identification of a new brain-specific transcription factor, NURR1. Law SW, etal., Mol Endocrinol. 1992 Dec;6(12):2129-35.
9. Expression patterns of Nurr1 in rat retina development. Li Y, etal., J Mol Histol. 2012 Dec;43(6):633-9. doi: 10.1007/s10735-012-9433-z. Epub 2012 Jun 20.
10. Expression of Nurr1 during rat brain and spinal cord development. Li Y, etal., Neurosci Lett. 2011 Jan 13;488(1):49-54. doi: 10.1016/j.neulet.2010.10.078. Epub 2010 Nov 5.
11. Developmental Vitamin D (DVD) Deficiency Reduces Nurr1 and TH Expression in Post-mitotic Dopamine Neurons in Rat Mesencephalon. Luan W, etal., Mol Neurobiol. 2018 Mar;55(3):2443-2453. doi: 10.1007/s12035-017-0497-3. Epub 2017 Apr 1.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Rapid increase of Nurr1 expression in the substantia nigra after 6-hydroxydopamine lesion in the striatum of the rat. Ojeda V, etal., J Neurosci Res 2003 Sep 1;73(5):686-97.
15. HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures. Pena de Ortiz S and Jamieson GA Jr, Brain Res Mol Brain Res. 1996 May;38(1):1-13.
16. Expression of nuclear hormone receptors within the rat hippocampus: identification of novel orphan receptors. Pena de Ortiz S, etal., Brain Res Mol Brain Res 1994 May;23(3):278-83.
17. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Rajan S, etal., Nat Chem Biol. 2020 Aug;16(8):876-886. doi: 10.1038/s41589-020-0553-6. Epub 2020 May 25.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors. Sacchetti P, etal., J Biol Chem 2002 Sep 20;277(38):35088-96.
22. RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. Scearce LM, etal., J Biol Chem 1993 Apr 25;268(12):8855-61.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures. Xing G, etal., Brain Res Mol Brain Res 1997 Jul;47(1-2):251-61.
25. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. Xu PY, etal., Neurology 2002 Mar 26;58(6):881-4.
Additional References at PubMed
PMID:7877627   PMID:8889548   PMID:8961274   PMID:9092472   PMID:9520484   PMID:9608532   PMID:10465447   PMID:10523643   PMID:10585298   PMID:11113533   PMID:11517332   PMID:11749040  
PMID:12385813   PMID:12787064   PMID:12849735   PMID:12915123   PMID:14528447   PMID:14622207   PMID:14671317   PMID:14742729   PMID:15009684   PMID:15155786   PMID:15485875   PMID:15591535  
PMID:15716272   PMID:16313515   PMID:16723737   PMID:16782508   PMID:17034791   PMID:17077287   PMID:17184956   PMID:17394463   PMID:17506860   PMID:18388149   PMID:18463503   PMID:18772553  
PMID:18815614   PMID:18945812   PMID:18951485   PMID:19133164   PMID:19144721   PMID:19150624   PMID:19321449   PMID:19362551   PMID:19429166   PMID:19515692   PMID:19906978   PMID:20533997  
PMID:20566846   PMID:21663595   PMID:22525717   PMID:22627286   PMID:23566817   PMID:23624190   PMID:24399192   PMID:24584059   PMID:24940803   PMID:25815475   PMID:26497037   PMID:26873851  
PMID:27219004   PMID:27435855   PMID:27553040   PMID:27687740   PMID:27826104   PMID:29145474   PMID:29152652   PMID:29450981   PMID:29565514   PMID:30634592   PMID:30949504   PMID:31000586  
PMID:31087449   PMID:31175960   PMID:31287373   PMID:31317490   PMID:32238479   PMID:33864663   PMID:34774582   PMID:35365988   PMID:37621064  


Genomics

Comparative Map Data
Nr4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,098,739 - 62,115,926 (-)NCBIGRCr8
mRatBN7.2341,689,847 - 41,707,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,028,318 - 45,033,797 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,613,078 - 53,618,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,404,666 - 51,410,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,111,258 - 43,128,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0348,183,106 - 48,192,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4338,866,205 - 38,871,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1338,763,218 - 38,769,911 (-)NCBI
Celera339,783,304 - 39,788,777 (-)NCBICelera
Cytogenetic Map3q21NCBI
NR4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382156,324,437 - 156,332,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2156,324,437 - 156,342,348 (-)EnsemblGRCh38hg38GRCh38
GRCh372157,180,949 - 157,189,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362156,889,195 - 156,897,446 (-)NCBINCBI36Build 36hg18NCBI36
Build 342157,006,458 - 157,014,708NCBI
Celera2150,794,299 - 150,802,639 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2149,066,205 - 149,074,545 (-)NCBIHuRef
CHM1_12157,187,025 - 157,195,368 (-)NCBICHM1_1
T2T-CHM13v2.02156,777,128 - 156,785,409 (-)NCBIT2T-CHM13v2.0
Nr4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39256,996,845 - 57,014,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl256,996,842 - 57,014,015 (-)EnsemblGRCm39 Ensembl
GRCm38257,106,830 - 57,124,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl257,106,830 - 57,124,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv37256,959,637 - 56,976,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36256,923,542 - 56,930,641 (-)NCBIMGSCv36mm8
Celera258,866,926 - 58,883,671 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Nr4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,937,794 - 16,945,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544916,928,780 - 16,944,536 (+)NCBIChiLan1.0ChiLan1.0
NR4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21358,993,305 - 59,002,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,004,662 - 59,016,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,584,835 - 43,593,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,828,823 - 160,837,162 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,826,091 - 160,837,162 (-)Ensemblpanpan1.1panPan2
NR4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,546,237 - 2,554,559 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,547,421 - 2,552,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha362,678,764 - 2,696,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,664,920 - 2,682,769 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,665,580 - 2,671,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,663,962 - 2,681,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,724,009 - 2,741,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,763,654 - 2,781,495 (-)NCBIUU_Cfam_GSD_1.0
Nr4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303119,697,239 - 119,705,622 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,912,047 - 21,920,486 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,912,118 - 21,920,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1563,487,731 - 63,495,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11563,487,051 - 63,506,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21570,671,034 - 70,689,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11041,715,092 - 41,724,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1041,715,086 - 41,723,685 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040157,834,500 - 157,843,891 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247329,581,779 - 9,589,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247329,572,160 - 9,589,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr4a2
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:60
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000041394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat

Markers in Region
D3Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,690,710 - 41,690,851 (+)MAPPERmRatBN7.2
Rnor_6.0343,112,122 - 43,112,262NCBIRnor6.0
Rnor_5.0348,183,970 - 48,184,110UniSTSRnor5.0
RGSC_v3.4338,866,394 - 38,866,534UniSTSRGSC3.4
Celera339,783,493 - 39,783,633UniSTS
Cytogenetic Map3q12UniSTS
RH138091  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,690,619 - 41,690,749 (+)MAPPERmRatBN7.2
Rnor_6.0343,112,031 - 43,112,160NCBIRnor6.0
Rnor_5.0348,183,879 - 48,184,008UniSTSRnor5.0
RGSC_v3.4338,866,303 - 38,866,432UniSTSRGSC3.4
Celera339,783,402 - 39,783,531UniSTS
RH 3.4 Map3538.0UniSTS
Cytogenetic Map3q12UniSTS
PMC109903P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,691,611 - 41,692,285 (+)MAPPERmRatBN7.2
Rnor_6.0343,113,023 - 43,113,696NCBIRnor6.0
Rnor_5.0348,184,871 - 48,185,544UniSTSRnor5.0
RGSC_v3.4338,867,295 - 38,867,968UniSTSRGSC3.4
Celera339,784,394 - 39,785,067UniSTS
Cytogenetic Map3q12UniSTS
Nr4a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,691,415 - 41,691,642 (+)MAPPERmRatBN7.2
Rnor_6.0343,112,827 - 43,113,053NCBIRnor6.0
Rnor_5.0348,184,675 - 48,184,901UniSTSRnor5.0
RGSC_v3.4338,867,099 - 38,867,325UniSTSRGSC3.4
Celera339,784,198 - 39,784,424UniSTS
Cytogenetic Map3q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58
Low 3 41 47 31 19 31 7 7 16 35 41 11 7
Below cutoff 2 10 10 10 1 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AW534944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB606493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ092634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000041394   ⟹   ENSRNOP00000043812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl341,689,851 - 41,697,877 (-)Ensembl
Rnor_6.0 Ensembl343,111,240 - 43,119,159 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078001   ⟹   ENSRNOP00000072142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl341,691,186 - 41,695,926 (-)Ensembl
Rnor_6.0 Ensembl343,112,597 - 43,117,337 (-)Ensembl
RefSeq Acc Id: NM_019328   ⟹   NP_062201
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,099,414 - 62,104,887 (-)NCBI
mRatBN7.2341,690,522 - 41,695,995 (-)NCBI
Rnor_6.0343,111,933 - 43,117,406 (-)NCBI
Rnor_5.0348,183,106 - 48,192,467 (-)NCBI
RGSC_v3.4338,866,205 - 38,871,678 (-)RGD
Celera339,783,304 - 39,788,777 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234201   ⟹   XP_006234263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,106,684 (-)NCBI
mRatBN7.2341,689,847 - 41,697,856 (-)NCBI
Rnor_6.0343,111,933 - 43,122,218 (-)NCBI
Rnor_5.0348,183,106 - 48,192,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591997   ⟹   XP_017447486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,115,926 (-)NCBI
mRatBN7.2341,689,847 - 41,707,036 (-)NCBI
Rnor_6.0343,111,933 - 43,128,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105737   ⟹   XP_038961665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,106,303 (-)NCBI
mRatBN7.2341,689,847 - 41,697,444 (-)NCBI
RefSeq Acc Id: XM_039105738   ⟹   XP_038961666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,098,739 - 62,106,684 (-)NCBI
mRatBN7.2341,689,847 - 41,697,790 (-)NCBI
RefSeq Acc Id: XM_063284415   ⟹   XP_063140485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,100,483 - 62,106,684 (-)NCBI
RefSeq Acc Id: XM_063284416   ⟹   XP_063140486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,100,483 - 62,106,684 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062201   ⟸   NM_019328
- UniProtKB: O35865 (UniProtKB/Swiss-Prot),   Q07917 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234263   ⟸   XM_006234201
- Peptide Label: isoform X1
- UniProtKB: O35865 (UniProtKB/Swiss-Prot),   Q07917 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447486   ⟸   XM_017591997
- Peptide Label: isoform X1
- UniProtKB: O35865 (UniProtKB/Swiss-Prot),   Q07917 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043812   ⟸   ENSRNOT00000041394
RefSeq Acc Id: ENSRNOP00000072142   ⟸   ENSRNOT00000078001
RefSeq Acc Id: XP_038961666   ⟸   XM_039105738
- Peptide Label: isoform X2
- UniProtKB: Q07917 (UniProtKB/Swiss-Prot),   O35865 (UniProtKB/Swiss-Prot),   Q3LZI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961665   ⟸   XM_039105737
- Peptide Label: isoform X1
- UniProtKB: Q07917 (UniProtKB/Swiss-Prot),   O35865 (UniProtKB/Swiss-Prot),   A6JF46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140486   ⟸   XM_063284416
- Peptide Label: isoform X4
- UniProtKB: Q3LZI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140485   ⟸   XM_063284415
- Peptide Label: isoform X3
- UniProtKB: Q3LZI7 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07917-F1-model_v2 AlphaFold Q07917 1-598 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692082
Promoter ID:EPDNEW_R2607
Type:initiation region
Name:Nr4a2_1
Description:nuclear receptor subfamily 4, group A, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0343,119,258 - 43,119,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3202 AgrOrtholog
BioCyc Gene G2FUF-49671 BioCyc
Ensembl Genes ENSRNOG00000005600 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041394.4 UniProtKB/TrEMBL
  ENSRNOT00000078001 ENTREZGENE
  ENSRNOT00000078001.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_orph_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NURR_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54278 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54278 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr4a2 PhenoGen
PRINTS NUCLEARECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NURRNUCRCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005600 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233109
UniProt A0A0G2JSV4_RAT UniProtKB/TrEMBL
  A6JF46 ENTREZGENE, UniProtKB/TrEMBL
  NR4A2_RAT UniProtKB/Swiss-Prot
  O35865 ENTREZGENE
  Q07917 ENTREZGENE
  Q3LZI4 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI5 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI7 ENTREZGENE, UniProtKB/TrEMBL
  Q3LZI8_RAT UniProtKB/TrEMBL
  Q3LZI9_RAT UniProtKB/TrEMBL
UniProt Secondary O35865 UniProtKB/Swiss-Prot
  Q3LZI6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr4a2  nuclear receptor subfamily 4, group A, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction heterodimerizes with retinoic X receptor (RXR)and binds direct repeat response elements 727393