Related Pages:
 Gene Ontology

Related Sites:
 Ratmap
 MGI
 NCBI
 UniGene
 HomoloGene
 Entrez Gene
 Gene Index Project


Gene:
Mapk3 ( Rattus norvegicus )
mitogen activated protein kinase 3
Description:kinase involved in intracellular signalling; component of Mapk signalling pathway
Synonyms:protein kinase; p44erk1; mitogen activated kinase 3; extracellular-signal-regulated kinase 1; ERK1; Erk-1; Protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1); mitogen-activated 3 (MAP kinase 3; p44); p44; p44mapk; Prkm3; Esrk1;  
ArrayIDs:A_43_P11930; rc_AI235753_at; M61177_s_at; 6150177; 6001316; 6404149; 6676363; 6526294; 6654853; 5904848; 5698564; 6179110; 5619583; 6145006; 1387771_a_at; 5779760; 5843199; 6077451; 6387696; 5695074; A_44_P404198; 6667656; A_44_P401179; 6509059; 5908193; 6237898; GE1119195; GE20517; 6310098; 5919042; 6417006; 6107082; 6161178; 5804150;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: MAPK3     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Mapk3     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusMapk3genome assembly 3.11186084924 - 186091127
  Rat Celera Assembly1179022318 - 179028392
  RGSC genome assembly v3.41185935044 - 185941246
  Cytogenetic1q36
Mus musculusMapk3Mouse genome assembly build 36.17133903140 - 133909330
  Cytogenetic77 F3
Homo sapiensMAPK3human genome assembly1630032927 - 30042039
  Human genome assembly build 36.21630032927 - 30042131
  Cytogenetic16p11.2
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
NoteReference
phosphorylates protein serine/threonine residues70317
Gene Ontology
protein kinase activity,  transcription regulator activity,  protein serine/threonine kinase activity ...  (details...)
Biological Process
NoteReference
mediates long-term memory and long-term potentiation (LTP)631303
translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons631303
estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP)70572
functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy70317
Gene Ontology
response to DNA damage stimulus,  response to lipopolysaccharide,  response to exogenous dsRNA ...  (details...)
Cellular Component
Gene Ontology
protein complex,  nucleus,  nucleolus ...  (details...)
Phenotype
Ontology
decreased thymocyte number (details...)
Expression
NoteReference
enzyme specific activity decreases with age70317
expressed in all tissues70317
Pathway
NoteReference
17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level70572
Ontology
the extracellular signal-regulated Raf/Mek/Erk signaling pathway (details...)
Domain
NoteReference
protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain70317, 70572
Regulation
NoteReference
induced by glutamate, acetylcholine, and BDNF in neurons631303
activated by Endothelin-1 (ET-1) in glomerular mesangial cells727457
24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells631303
ouabain induces activation in cardiac myocytes631303
1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes631303
highly responsive to extracellular proliferative stimuli70310, 70572
activated by estrogen in hippocampus, downregulation by ovariectomy70572
activated by Map2k1, Mek2 phosphorylation625493
 
 External Links
Databases
DATABASEIDSOURCE
SMART:S_TKcIPI
PROSITE:PROTEIN_KINASE_STIPI
PROSITE:PROTEIN_KINASE_DOMIPI
PROSITE:PROTEIN_KINASE_ATPIPI
PROSITE:MAPKIPI
UNIPARC:UPI000019C1BFIPI
UNIPARC:UPI0000DC2219IPI
UNIPARC:UPI0000250F85IPI
KEGG Report:rno:50689ENTREZGENE
HomoloGene Group ID:55682ENTREZGENE
Germonline:3046
Pfam:PkinaseIPI
KEGG Pathway:05216ENTREZGENE
KEGG Pathway:04350ENTREZGENE
KEGG Pathway:04150ENTREZGENE
KEGG Pathway:04270ENTREZGENE
KEGG Pathway:04370ENTREZGENE
KEGG Pathway:04930ENTREZGENE
KEGG Pathway:04620ENTREZGENE
KEGG Pathway:04660ENTREZGENE
KEGG Pathway:05211ENTREZGENE
KEGG Pathway:04810ENTREZGENE
KEGG Pathway:05215ENTREZGENE
KEGG Pathway:05020ENTREZGENE
KEGG Pathway:05200ENTREZGENE
KEGG Pathway:05212ENTREZGENE
KEGG Pathway:05223ENTREZGENE
KEGG Pathway:04722ENTREZGENE
KEGG Pathway:04650ENTREZGENE
KEGG Pathway:05218ENTREZGENE
KEGG Pathway:04916ENTREZGENE
KEGG Pathway:04010ENTREZGENE
KEGG Pathway:04720ENTREZGENE
KEGG Pathway:04730ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:04912ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04540ENTREZGENE
KEGG Pathway:04510ENTREZGENE
KEGG Pathway:04666ENTREZGENE
KEGG Pathway:04664ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:05213ENTREZGENE
KEGG Pathway:04320ENTREZGENE
KEGG Pathway:05210ENTREZGENE
KEGG Pathway:05220ENTREZGENE
KEGG Pathway:04062ENTREZGENE
KEGG Pathway:05219ENTREZGENE
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04360ENTREZGENE
KEGG Pathway:05010ENTREZGENE
KEGG Pathway:04520ENTREZGENE
KEGG Pathway:05221ENTREZGENE
InterPro:Ser/Thr_prot_kinase_dom.IPI
InterPro:Ser/Thr_prot_kinase_AS.IPI
InterPro:Se/Thr_prot_kinase-like_dom.IPI
InterPro:Protein_kinase_ATP_BS.IPI
InterPro:Prot_kinase_cat_dom.IPI
InterPro:MAP_kinase_CS.IPI
InterPro:Kinase-like_dom.IPI
InterPro:Erk_1_2_MAPK.IPI
IPI:IPI00206172IPI
IPI:IPI00776948IPI
IPI:IPI00231081IPI
Ensembl Protein:ENSRNOP00000026627IPI
Ensembl Protein:ENSRNOP00000051901IPI
Entrez Gene:Mapk3ENTREZGENE
UniProt:MK03_RATIPI
UniProt:MK03_RATIPI
Ensembl Genes:ENSRNOG00000019601IPI
RatMap:44625ENTREZGENE
Superfamily-SCOP:Kinase_likeIPI
PRINTS:ERK1ERK2MAPK.IPI
Sequences
Nucleotide:M38194Get FASTASearch GEO Profiles
Nucleotide:U12008Get FASTASearch GEO Profiles
Nucleotide:S46779Get FASTASearch GEO Profiles
Nucleotide:M61177Get FASTASearch GEO Profiles
Nucleotide:X65198Get FASTASearch GEO Profiles
Nucleotide:AF155236Get FASTASearch GEO Profiles
Nucleotide:XM_001079997Get FASTASearch GEO Profiles
Nucleotide:NM_017347Get FASTASearch GEO Profiles
(View all 8 Nucleotide Accessions)
Protein:P21708Get FASTA
Protein:CAA46318Get FASTA
Protein:AAA20009Get FASTA
Protein:AAA11604Get FASTA
Protein:AAA63486Get FASTA
Protein:AAA41123Get FASTA
Protein:AAF71666Get FASTA
Protein:XP_001079997Get FASTA
Protein:NP_059043Get FASTA
(View all 9 Protein Accessions)
Clusters
UniGene:2592
 
 References
Curated References
28 references in RGD related to Mapk3
Other References
314 other references at PubMed related to Mapk3
 
 Database Information
RGD ID3046
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
10-SEP-04: Mapk3 mitogen activated protein kinase 3 protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1) APPROVED Name updated 1299863
10-JUN-02: Mapk3 mitogen activated protein kinase 3 APPROVED Symbol and Name status set to approved 70586

       

Contact Us |  About Us |  Jobs at RGD