Mapk3 (mitogen activated protein kinase 3) - Rat Genome Database

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Gene: Mapk3 (mitogen activated protein kinase 3) Rattus norvegicus
Analyze
Symbol: Mapk3
Name: mitogen activated protein kinase 3
RGD ID: 3046
Description: Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonate metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytoplasm; and nucleoplasm. Part of protein-containing complex. Used to study several diseases, including alcohol dependence; cocaine abuse; drug dependence (multiple); gastric ulcer; and middle cerebral artery infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Erk-1; ERK1; ERT2; Esrk1; extracellular signal-regulated kinase 1; extracellular-signal-regulated kinase 1; insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK1; microtubule-associated protein 2 kinase; mitogen activated kinase 3; mitogen-activated 3; mitogen-activated 3 (MAP kinase 3, p44); mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; MNK1; p44; p44-ERK1; p44-MAPK; p44erk1; p44mapk; Prkm3; Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1); Protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mapk3RatAberrant Crypt Foci  ISOMAPK3 (Homo sapiens)13210776 RGD 
Mapk3Ratalcohol dependence treatmentIDA 401959604 RGD 
Mapk3Ratalcohol use disorder  IEP 401959334protein:increased expression:liverRGD 
Mapk3RatAlzheimer's disease treatmentISOMapk3 (Mus musculus)13800563 RGD 
Mapk3Ratcocaine abuse  IDA 401851063protein:increased phosphorylation:nucleus accumbensRGD 
Mapk3Ratcocaine dependence  IDA 401851078protein:increased phosphorylation:brainRGD 
Mapk3Ratcolon adenocarcinoma  ISOMAPK3 (Homo sapiens)13210775 RGD 
Mapk3Ratcolorectal adenocarcinoma treatmentISOMAPK3 (Homo sapiens)13210782 RGD 
Mapk3RatColorectal Neoplasms  ISOMAPK3 (Homo sapiens)13210794 RGD 
Mapk3RatDiabetic Cardiomyopathies treatmentIDA 13800893associated with Diabetes Mellitus and ExperimentalRGD 
Mapk3Ratendometrial adenocarcinoma treatmentISOMAPK3 (Homo sapiens)13703125human tumor in a mouse modelRGD 
Mapk3Ratendometrial adenocarcinoma  ISOMAPK3 (Homo sapiens)13703137protein:decreased phosphorylation:endometrium (human)RGD 
Mapk3Ratendometrial carcinoma  ISOMAPK3 (Homo sapiens)13702082protein:increased expression:endometrium (human)RGD 
Mapk3Ratendometrial carcinoma severityISOMAPK3 (Homo sapiens)13441552protein:increased phosphorylation:endometrium (human)RGD 
Mapk3RatEndometrial Neoplasms treatmentISOMAPK3 (Homo sapiens)13441559 RGD 
Mapk3RatEndometrioid Carcinomas treatmentISOMAPK3 (Homo sapiens)13441559 RGD 
Mapk3RatExperimental Colitis treatmentIDA 13800567 RGD 
Mapk3RatExperimental Diabetes Mellitus  IDA 5131482protein:decreased phosphorylation:corneaRGD 
Mapk3RatExperimental Liver Cirrhosis treatmentIEP 13800880 RGD 
Mapk3RatExperimental Mammary Neoplasms treatmentIDA 13800872 RGD 
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Original Reference(s)
Mapk3Ratautism spectrum disorder  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:18184952 and PMID:25255310
Mapk3Ratautistic disorder  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Mapk3Ratchromosome 16p11.2 deletion syndrome, 593-kb  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Proximal 16p11.2 microdeletion syndromeClinVarPMID:25741868 and PMID:31690835
Mapk3Ratchromosome 16p11.2 duplication syndrome  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16p11.2 duplication syndromeClinVarPMID:31690835
Mapk3Ratcoronin-1A deficiency  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 8ClinVarPMID:14615364 more ...
Mapk3Ratdilated cardiomyopathy  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated Cardiomyopathy and DominantClinVarPMID:28492532
Mapk3RatEpisodic Kinesigenic Dyskinesia  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Episodic kinesigenic dyskinesiaClinVarPMID:14615364 more ...
Mapk3Ratepisodic kinesigenic dyskinesia 1  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Paroxysmal kinesigenic dyskinesiaClinVarPMID:14615364 more ...
Mapk3RatGlycogen Storage Disease XII  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Red cell aldolase deficiencyClinVarPMID:14615364 more ...
Mapk3RatNeurodevelopmental Disorders  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Mapk3Ratschizophrenia  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Mapk3Ratspondylocostal dysostosis 5  ISOMAPK3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23335591 more ...
Mapk3Ratspondylocostal dysostosis 5  ISOMAPK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Spondylocostal dysostosis 5ClinVarPMID:23335591 more ...
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Original Reference(s)
Mapk3RatAnimal Disease Models  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
Mapk3RatAtrophy  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16391472
Mapk3Ratautistic disorder  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30559488
Mapk3Ratbrain ischemia  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17901229
Mapk3Ratcardiomyopathy  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:10620750
Mapk3RatCocaine-Related Disorders  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20692647
Mapk3RatCoronavirus infectious disease  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20484496
Mapk3RatDevelopmental Disabilities  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30559488
Mapk3RatExperimental Liver Neoplasms  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28100771
Mapk3RatExperimental Radiation Injuries  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22247605
Mapk3Ratextrahepatic cholestasis  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
Mapk3RatFemale Infertility  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21177758
Mapk3RatGliosis  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19402951
Mapk3RatHead and Neck Neoplasms  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15342401
Mapk3RatHyperalgesia  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12941468 and PMID:27093858
Mapk3RatHypertrophy  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12237323
Mapk3RatKidney Neoplasms  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21813464
Mapk3RatLung Neoplasms  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11884234 and PMID:12083368
Mapk3RatNeoplasm Invasiveness  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22580338
Mapk3RatNeoplasm Metastasis  ISOMAPK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22580338
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Original Reference(s)
Mapk3Rat(+)-alpha-viniferin multiple interactionsISOMapk3 (Mus musculus)6480464alpha-viniferin inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]CTDPMID:20424383
Mapk3Rat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]CTDPMID:20977430
Mapk3Rat(+)-catechin increases phosphorylationISOMapk3 (Mus musculus)6480464Catechin results in increased phosphorylation of MAPK3 proteinCTDPMID:15879681
Mapk3Rat(+)-catechin multiple interactionsISOMapk3 (Mus musculus)6480464Catechin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]CTDPMID:20883750
Mapk3Rat(+)-catechin increases phosphorylationISOMAPK3 (Homo sapiens)6480464Catechin results in increased phosphorylation of MAPK3 proteinCTDPMID:17379280
Mapk3Rat(+)-catechin multiple interactionsISOMAPK3 (Homo sapiens)6480464Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK3 protein] and Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]CTDPMID:19557821 and PMID:21882252
Mapk3Rat(+)-catechin decreases phosphorylationISOMAPK3 (Homo sapiens)6480464Catechin analog results in decreased phosphorylation of MAPK3 proteinCTDPMID:16413414
Mapk3Rat(+)-dihydromyricetin multiple interactionsEXP 6480464ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]CTDPMID:21871475
Mapk3Rat(+)-epicatechin-3-O-gallate increases phosphorylationISOMAPK3 (Homo sapiens)6480464epicatechin gallate results in increased phosphorylation of MAPK3 proteinCTDPMID:21945981
Mapk3Rat(+)-pilocarpine increases phosphorylationISOMapk3 (Mus musculus)6480464Pilocarpine results in increased phosphorylation of MAPK3 proteinCTDPMID:19402951
Mapk3Rat(+)-pilocarpine increases phosphorylationEXP 6480464Pilocarpine results in increased phosphorylation of MAPK3 proteinCTDPMID:18988310 and PMID:22824136
Mapk3Rat(+)-pilocarpine multiple interactionsEXP 6480464Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein] and ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]CTDPMID:18988310 and PMID:22824136
Mapk3Rat(+)-pilocarpine multiple interactionsISOMapk3 (Mus musculus)6480464Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein more ...CTDPMID:12091480 more ...
Mapk3Rat(+)-Pimaric acid multiple interactionsISOMAPK3 (Homo sapiens)6480464pimaric acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]CTDPMID:22705379
Mapk3Rat(+)-schisandrin B increases activityISOMapk3 (Mus musculus)6480464schizandrin B results in increased activity of MAPK3 proteinCTDPMID:21250784
Mapk3Rat(+)-schisandrin B multiple interactionsISOMapk3 (Mus musculus)6480464schizandrin B promotes the reaction [Vitamin K 3 results in increased activity of MAPK3 protein]CTDPMID:21250784
Mapk3Rat(+)-Tetrandrine multiple interactionsEXP 6480464tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]CTDPMID:22001142
Mapk3Rat(+)-Tetrandrine multiple interactionsISOMAPK3 (Homo sapiens)6480464[arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein more ...CTDPMID:31934280
Mapk3Rat(+)-Tetrandrine increases phosphorylationISOMAPK3 (Homo sapiens)6480464tetrandrine results in increased phosphorylation of MAPK3 proteinCTDPMID:31934280
Mapk3Rat(-)-anisomycin increases expressionEXP 6480464Anisomycin results in increased expression of MAPK3 protein modified formCTDPMID:25233930

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Biological Process
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Original Reference(s)
Mapk3Ratanimal organ morphogenesis acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291 PMID:11684667RGDPMID:11684667
Mapk3Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Mapk3Ratarachidonate metabolic process  IEP 1626220 RGD 
Mapk3RatBergmann glial cell differentiation acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291MGI:1346858 PMID:24431450RGDPMID:24431450
Mapk3RatBMP signaling pathway involved_inISOMAPK3 (Homo sapiens)1624291 PMID:19664780RGDPMID:19664780
Mapk3Ratcardiac neural crest cell development involved in heart development acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291MGI:1346858 PMID:18952847RGDPMID:18952847
Mapk3Ratcartilage development acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291 PMID:17644814RGDPMID:17644814
Mapk3Ratcaveolin-mediated endocytosis involved_inTAS 8553538PMID:19565474UniProt 
Mapk3Ratcaveolin-mediated endocytosis involved_inIEAARBA:ARBA000286931600115GO_REF:0000117UniProtGO_REF:0000117
Mapk3Ratcell surface receptor signaling pathway involved_inIBAFB:FBgn0003256 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk3Ratcellular response to amino acid starvation involved_inISOMAPK3 (Homo sapiens)1624291 PMID:11096076RGDPMID:11096076
Mapk3Ratcellular response to mechanical stimulus involved_inISOMAPK3 (Homo sapiens)1624291 PMID:19593445RGDPMID:19593445
Mapk3Ratcellular response to toxic substance  IDA 1582285 RGD 
Mapk3Ratcellular response to tumor necrosis factor acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291MGI:1346858 PMID:24349514RGDPMID:24349514
Mapk3Ratdecidualization  IDA 8553214 RGD 
Mapk3RatDNA damage response acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291 PMID:15383658RGDPMID:15383658
Mapk3RatDNA-templated transcription involved_inISOMapk3 (Mus musculus)1624291 PMID:7889942RGDPMID:7889942
Mapk3Ratepidermal growth factor receptor signaling pathway involved_inISOMAPK3 (Homo sapiens)1624291 PMID:24854121RGDPMID:24854121
Mapk3RatERBB2-ERBB3 signaling pathway involved_inISOMapk3 (Mus musculus)1624291 PMID:24493648RGDPMID:24493648
Mapk3RatERK1 and ERK2 cascade acts_upstream_of_or_withinISOMapk3 (Mus musculus)1624291MGI:1346858 PMID:19047410RGDPMID:19047410
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Cellular Component
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Original Reference(s)
Mapk3Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Mapk3Ratcaveola located_inTAS 8553538PMID:19565474UniProt 
Mapk3Ratcaveola located_inIEAUniProtKB-SubCell:SL-00351600115GO_REF:0000044UniProtGO_REF:0000044
Mapk3Ratcaveola located_inIDA 12907554PMID:24567387UniProt 
Mapk3Ratciliary basal body located_inISOMAPK3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Mapk3Ratcilium located_inISOMAPK3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Mapk3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Mapk3Ratcytoplasm located_inISOMapk3 (Mus musculus)1624291 PMID:11726647 and PMID:12223545RGDPMID:11726647 and PMID:12223545
Mapk3Ratcytoplasm is_active_inIBACGD:CAL0000197240 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk3Ratcytoplasm located_inIDA 12907554PMID:24567387UniProt 
Mapk3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Mapk3Ratcytoplasm is_active_inISOMAPK3 (Homo sapiens)1624291 PMID:37208329RGDPMID:37208329
Mapk3Ratcytoskeleton located_inTAS 8553538PMID:19565474UniProt 
Mapk3Ratcytosol located_inISOMapk3 (Mus musculus)1624291 PMID:22451653RGDPMID:22451653
Mapk3Ratcytosol located_inTAS 8553538PMID:19565474UniProt 
Mapk3Ratcytosol located_inTAS 1600115Reactome:R-NUL-997411ReactomeReactome:R-NUL-997411
Mapk3Ratearly endosome located_inTAS 8553538PMID:19565474UniProt 
Mapk3Ratearly endosome located_inIEAARBA:ARBA000285671600115GO_REF:0000117UniProtGO_REF:0000117
Mapk3Ratfocal adhesion located_inTAS 8553538PMID:19565474UniProt 
Mapk3Ratfocal adhesion located_inIEAUniProtKB-SubCell:SL-01181600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Mapk3RatATP binding  IDA 1626220 RGD 
Mapk3RatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mapk3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Mapk3RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Mapk3RatDNA-binding transcription factor binding enablesISOMAPK3 (Homo sapiens)1624291UniProtKB:Q9BQW3 and PMID:35939714RGDPMID:35939714
Mapk3Ratidentical protein binding enablesISOMAPK3 (Homo sapiens)1624291UniProtKB:P27361 more ...RGDPMID:16627622 and PMID:22307056
Mapk3Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Mapk3RatMAP kinase activity  IDA 1626220 RGD 
Mapk3RatMAP kinase activity enablesIEAEC:2.7.11.241600115GO_REF:0000003UniProtGO_REF:0000003
Mapk3RatMAP kinase activity enablesIEAInterPro:IPR003527 and InterPro:IPR0083491600115GO_REF:0000002InterProGO_REF:0000002
Mapk3RatMAP kinase activity enablesIEAARBA:ARBA000276891600115GO_REF:0000117UniProtGO_REF:0000117
Mapk3RatMAP kinase activity enablesISOMapk3 (Mus musculus)1624291 PMID:11841548 more ...RGDPMID:11841548 more ...
Mapk3RatMAP kinase activity enablesISOMAPK3 (Homo sapiens)1624291 PMID:8388392RGDPMID:8388392
Mapk3RatMAP kinase activity enablesIDA 8554315PMID:7889942UniProt 
Mapk3RatMAP kinase activity  IMP 8553011 RGD 
Mapk3Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Mapk3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Mapk3Ratphosphatase binding enablesISOMAPK3 (Homo sapiens)1624291UniProtKB:Q12913 and PMID:19494114RGDPMID:19494114
Mapk3Ratphosphotyrosine residue binding enablesISOMapk3 (Mus musculus)1624291 PMID:14636584RGDPMID:14636584
Mapk3Ratprotein binding  IPIArrb2 (Rattus norvegicus)5510003 RGD 
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Mapk3Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Mapk3Rataldosterone signaling pathway   IEA 6907045 KEGGrno:04960
Mapk3RatAlzheimer's disease pathway   IEA 6907045 KEGGrno:05010
Mapk3RatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
Mapk3Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Mapk3RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Mapk3Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Mapk3Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Mapk3Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Mapk3Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Mapk3Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Mapk3RatFc epsilon receptor mediated signaling pathway  IEA 6907045 KEGGrno:04664
Mapk3RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666
Mapk3Ratglioma pathway  IEA 6907045 KEGGrno:05214
Mapk3Ratglutamate signaling pathway  IEA 6907045 KEGGrno:04724
Mapk3Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Mapk3Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Mapk3Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Mapk3Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Mapk3RatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
1 to 20 of 41 rows

Imported Annotations - PID (archival)

1 to 18 of 18 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mapk3Ratceramide signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200119
Mapk3Ratendothelin signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200005
Mapk3Ratephrin - ephrin receptor bidirectional signaling axis  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200052
Mapk3Ratepidermal growth factor/neuregulin signaling pathway   ISOMAPK3 (Homo sapiens)6484113 PIDPID:200101
Mapk3Ratfibroblast growth factor signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200220
Mapk3Ratgranulocyte-macrophage colony-stimulating factor signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200019
Mapk3Ratinterleukin-2 signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200098
Mapk3RatmTOR signaling pathway   ISOMAPK3 (Homo sapiens)6484113 PIDPID:200096
Mapk3Ratplatelet-derived growth factor signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200149
Mapk3Ratsphingosine 1-phosphate signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200046
Mapk3Ratsphingosine 1-phosphate signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200054
Mapk3Ratsphingosine 1-phosphate signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200085
Mapk3Ratsphingosine 1-phosphate signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200211
Mapk3Ratsyndecan signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200156
Mapk3Ratsyndecan signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200192
Mapk3RatTrail mediated signaling pathway   ISOMAPK3 (Homo sapiens)6484113 PIDPID:200068
Mapk3Rattype II interferon signaling pathway  ISOMAPK3 (Homo sapiens)6484113 PIDPID:200129
Mapk3Ratvascular endothelial growth factor signaling pathway   ISOMAPK3 (Homo sapiens)6484113 PIDPID:200188
1 to 18 of 18 rows

1 to 20 of 96 rows
#
Reference Title
Reference Citation
1. Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Bi R, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13391-5.
2. P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Bradford MD and Soltoff SP, Biochem J 2002 Sep 15;366(Pt 3):745-55.
3. Bradykinin reduces growth factor-induced glomerular ERK1/2 phosphorylation. Cellier E, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F282-92.
4. Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: evidence for involvement of GPR30/EGFR signaling pathway. Chandra V, etal., Gynecol Oncol. 2013 May;129(2):433-42. doi: 10.1016/j.ygyno.2013.02.005. Epub 2013 Feb 8.
5. Systemic dexmedetomidine attenuates mechanical allodynia through extracellular sign db type 2 diabetic mice. Chen H, etal., Neurosci Lett. 2017 Sep 14;657:126-133. doi: 10.1016/j.neulet.2017.07.048. Epub 2017 Jul 28.
6. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
7. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Chen S, etal., J Cereb Blood Flow Metab. 2007 May;27(5):939-49. Epub 2006 Aug 30.
8. Pfaffia paniculata (Brazilian ginseng) extract modulates Mapk and mucin pathways in intestinal inflammation. Costa CARA, etal., J Ethnopharmacol. 2018 Mar 1;213:21-25. doi: 10.1016/j.jep.2017.10.009. Epub 2017 Oct 14.
9. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Desouki MM and Rowan BG, Clin Cancer Res. 2004 Jan 15;10(2):546-55.
10. Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Drew DA, etal., Proteomics. 2013 May;13(9):1428-36. doi: 10.1002/pmic.201200430. Epub 2013 Apr 4.
11. Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7ß-Aurora A pathway. Duhamel S, etal., Cell Cycle. 2016 Jun 17;15(12):1631-42. doi: 10.1080/15384101.2016.1183851. Epub 2016 May 6.
12. Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. Eggstein S, etal., Gut. 1999 Jun;44(6):834-8.
13. Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins. Esmaili-Shahzade-Ali-Akbari P, etal., Neurotoxicology. 2021 May;84:64-72. doi: 10.1016/j.neuro.2021.02.005. Epub 2021 Feb 18.
14. Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats. Fathi D, etal., Life Sci. 2021 Nov 1;284:119904. doi: 10.1016/j.lfs.2021.119904. Epub 2021 Aug 25.
15. Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. Föcking M, etal., Mol Psychiatry. 2015 Apr;20(4):424-32. doi: 10.1038/mp.2014.63. Epub 2014 Jul 22.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. Gille H, etal., EMBO J. 1995 Mar 1;14(5):951-62.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Gorin Y, etal., Biochem J. 2004 Jul 1;381(Pt 1):231-9.
20. Intranasal Lactoferrin Enhances a-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1a Pathways in an Alzheimer's Disease Mouse Model. Guo C, etal., Neuropsychopharmacology. 2017 Dec;42(13):2504-2515. doi: 10.1038/npp.2017.8. Epub 2017 Jan 12.
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1 to 10 of 52 rows
PMID:1327976   PMID:1712480   PMID:1716439   PMID:1846291   PMID:2164259   PMID:7687743   PMID:7939721   PMID:8388392   PMID:9535927   PMID:9857190   PMID:11096076   PMID:11254359  
PMID:11356865   PMID:11684667   PMID:11726647   PMID:11756441   PMID:11832339   PMID:11841548   PMID:11844932   PMID:11994045   PMID:11994544   PMID:12006386   PMID:12121979   PMID:12213812  
PMID:12223545   PMID:12349907   PMID:12435482   PMID:12535947   PMID:12623863   PMID:12645629   PMID:12663469   PMID:12699904   PMID:12730054   PMID:12783880   PMID:12800247   PMID:12810726  
PMID:12821670   PMID:12849998   PMID:12854829   PMID:12871576   PMID:12872135   PMID:12930843   PMID:12935895   PMID:12952860   PMID:12971962   PMID:14501944   PMID:14552884   PMID:14575703  
PMID:14580718   PMID:14593093   PMID:14605008   PMID:14636584   PMID:14741046   PMID:14769808   PMID:14963006   PMID:14984009   PMID:14988413   PMID:15026121   PMID:15030400   PMID:15030409  
PMID:15051723   PMID:15052686   PMID:15059773   PMID:15072963   PMID:15143154   PMID:15158083   PMID:15201339   PMID:15203192   PMID:15229233   PMID:15242988   PMID:15249196   PMID:15257182  
PMID:15262203   PMID:15297310   PMID:15314156   PMID:15322069   PMID:15365619   PMID:15371543   PMID:15383658   PMID:15489642   PMID:15498890   PMID:15537896   PMID:15569628   PMID:15573401  
PMID:15574735   PMID:15617763   PMID:15650391   PMID:15721216   PMID:15731359   PMID:15737734   PMID:15748847   PMID:15778391   PMID:15811423   PMID:15829913   PMID:15845362   PMID:15851690  
PMID:15899886   PMID:15917991   PMID:15921682   PMID:15922485   PMID:15950189   PMID:15964695   PMID:15964902   PMID:15975921   PMID:15975997   PMID:15991247   PMID:16004581   PMID:16024175  
PMID:16044092   PMID:16106045   PMID:16126724   PMID:16126730   PMID:16139272   PMID:16272159   PMID:16283431   PMID:16326014   PMID:16343798   PMID:16482086   PMID:16510265   PMID:16535835  
1 to 10 of 52 rows



Mapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
MAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,114,105 - 30,123,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,114,105 - 30,123,506 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,125,426 - 30,134,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,032,927 - 30,042,131 (-)NCBINCBI36Build 36hg18NCBI36
Build 341630,032,927 - 30,042,039NCBI
Celera1672,661,419 - 72,670,625 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,786,557 - 27,795,763 (-)NCBIHuRef
CHM1_11631,341,181 - 31,350,385 (-)NCBICHM1_1
T2T-CHM13v2.01630,396,752 - 30,405,867 (-)NCBIT2T-CHM13v2.0
Mapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,358,798 - 126,364,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,358,773 - 126,364,991 (+)EnsemblGRCm39 Ensembl
GRCm387126,759,626 - 126,765,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,759,601 - 126,765,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,903,140 - 133,909,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,550,780 - 126,556,964 (+)NCBIMGSCv36mm8
Celera7126,607,166 - 126,613,154 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Mapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
MAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,864,038 - 30,873,180 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,352,686 - 35,361,831 (+)NCBINHGRI_mPanPan1
PanPan1.11630,489,362 - 30,498,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,489,362 - 30,498,017 (-)Ensemblpanpan1.1panPan2
MAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBIUU_Cfam_GSD_1.0
Mapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,287,605 - 124,292,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,384,804 - 12,392,180 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,342,670 - 12,390,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,536,471 - 26,545,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,536,532 - 26,546,461 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,993,354 - 3,002,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,152,039 - 13,159,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,150,824 - 13,158,327 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Mapk3
26 total Variants

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:73
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000026627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 85 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat

1 to 10 of 85 rows
Prkm3-rs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,372,667 - 181,372,836 (+)MAPPERmRatBN7.2
Rnor_6.01198,198,785 - 198,198,953NCBIRnor6.0
Rnor_5.01205,178,653 - 205,178,821UniSTSRnor5.0
RGSC_v3.41185,941,056 - 185,941,224UniSTSRGSC3.4
Celera1179,028,196 - 179,028,364UniSTS
Cytogenetic Map1q36UniSTS
BI278071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,372,449 - 181,372,636 (+)MAPPERmRatBN7.2
mRatBN7.21142,352,418 - 42,352,605 (+)MAPPERmRatBN7.2
Rnor_6.01144,459,798 - 44,459,984NCBIRnor6.0
Rnor_6.01198,198,567 - 198,198,753NCBIRnor6.0
Rnor_5.01147,652,898 - 47,653,084UniSTSRnor5.0
Rnor_5.01205,178,435 - 205,178,621UniSTSRnor5.0
RGSC_v3.41185,940,838 - 185,941,024UniSTSRGSC3.4
RGSC_v3.41143,172,337 - 43,172,523UniSTSRGSC3.4
Celera1142,150,435 - 42,150,621UniSTS
Celera1179,027,978 - 179,028,164UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map1q36UniSTS
Mapk3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,352,315 - 42,353,222 (+)MAPPERmRatBN7.2
Rnor_6.01144,459,695 - 44,460,601NCBIRnor6.0
Rnor_5.01147,652,795 - 47,653,701UniSTSRnor5.0
RGSC_v3.41143,172,234 - 43,173,140UniSTSRGSC3.4
Celera1142,150,332 - 42,151,238UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map1q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000087625   ⟹   ENSRNOP00000070784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)Ensembl
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)Ensembl
RefSeq Acc Id: NM_017347   ⟹   NP_059043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,797,194 - 190,803,411 (+)NCBI
mRatBN7.21181,366,646 - 181,372,863 (+)NCBI
Rnor_6.01198,192,773 - 198,198,975 (+)NCBI
Rnor_5.01205,172,641 - 205,178,843 (+)NCBI
RGSC_v3.41185,935,044 - 185,941,245 (+)RGD
Celera1179,022,318 - 179,028,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088525   ⟹   XP_038944453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,797,189 - 190,803,410 (+)NCBI
mRatBN7.21181,366,650 - 181,372,862 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_059043 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944453 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA11604 (Get FASTA)   NCBI Sequence Viewer  
  AAA20009 (Get FASTA)   NCBI Sequence Viewer  
  AAA41123 (Get FASTA)   NCBI Sequence Viewer  
  AAA63486 (Get FASTA)   NCBI Sequence Viewer  
  AAF71666 (Get FASTA)   NCBI Sequence Viewer  
  CAA46318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026688
  ENSRNOP00000110992
GenBank Protein P21708 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_059043   ⟸   NM_017347
- UniProtKB: Q62686 (UniProtKB/Swiss-Prot),   Q4PIY8 (UniProtKB/Swiss-Prot),   P21708 (UniProtKB/Swiss-Prot),   Q9JJ13 (UniProtKB/Swiss-Prot),   A0A8L2R3C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070784   ⟸   ENSRNOT00000087625
RefSeq Acc Id: XP_038944453   ⟸   XM_039088525
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R3C3 (UniProtKB/TrEMBL)
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P21708-F1-model_v2 AlphaFold P21708 1-380 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690409
Promoter ID:EPDNEW_R934
Type:multiple initiation site
Name:Mapk3_1
Description:mitogen activated protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,192,787 - 198,192,847EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57423 BioCyc
Ensembl Genes ENSRNOG00000053583 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026688 ENTREZGENE
  ENSRNOT00000165309 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_ERK1/2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:50689 UniProtKB/Swiss-Prot
NCBI Gene 50689 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAPK3 RGD
PhenoGen Mapk3 PhenoGen
PRINTS ERK1ERK2MAPK UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053583 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2R3C3 ENTREZGENE, UniProtKB/TrEMBL
  MK03_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4PIY8 ENTREZGENE
  Q62686 ENTREZGENE
  Q9JJ13 ENTREZGENE
UniProt Secondary Q4PIY8 UniProtKB/Swiss-Prot
  Q62686 UniProtKB/Swiss-Prot
  Q9JJ13 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mapk3  mitogen activated protein kinase 3    protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)  Name updated 1299863 APPROVED
2002-06-10 Mapk3  mitogen activated protein kinase 3      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_domains protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain 70317
gene_domains protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain 70572
gene_expression enzyme specific activity decreases with age 70317
gene_expression expressed in all tissues 70317
gene_function phosphorylates protein serine/threonine residues 70317
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_process functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy 70317
gene_process mediates long-term memory and long-term potentiation (LTP) 631303
gene_process translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons 631303
gene_regulation highly responsive to extracellular proliferative stimuli 70310
gene_regulation highly responsive to extracellular proliferative stimuli 70572
gene_regulation activated by estrogen in hippocampus, downregulation by ovariectomy 70572
gene_regulation activated by Map2k1, Mek2 phosphorylation 625493
gene_regulation induced by glutamate, acetylcholine, and BDNF in neurons 631303
gene_regulation activated by Endothelin-1 (ET-1) in glomerular mesangial cells 727457
gene_regulation 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells 631303
gene_regulation ouabain induces activation in cardiac myocytes 631303
gene_regulation 1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes 631303