Icam1 (intercellular adhesion molecule 1) - Rat Genome Database

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Gene: Icam1 (intercellular adhesion molecule 1) Rattus norvegicus
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Symbol: Icam1
Name: intercellular adhesion molecule 1
RGD ID: 2857
Description: Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to dexamethasone stimulus; and gonad development. Located in cell surface and extracellular space. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Graves ophthalmopathy; Graves' disease; biliary atresia; and inflammatory bowel disease (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; eicosanoid signaling pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; (+)-Tetrandrine; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD54; ICAM; ICAM-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,829,688 - 27,841,618 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,829,161 - 27,841,617 (+)EnsemblGRCr8
mRatBN7.2819,553,063 - 19,565,438 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,553,645 - 19,565,438 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,573,091 - 23,584,847 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,870,936 - 21,882,706 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,783,338 - 19,795,094 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,035,287 - 22,047,049 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)Ensemblrn6Rnor6.0
Rnor_5.0822,092,155 - 22,103,917 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,040,177 - 20,051,939 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,948,090 - 20,959,852 (+)NCBICelera
RGSC_v3.1820,040,176 - 20,051,939 (+)NCBI
RH 3.4 Map8206.11RGD
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP,IMP)
acute kidney failure  (IEP)
Acute Lung Injury  (IEP,ISO)
acute necrotizing pancreatitis  (IEP)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Animal Hepatitis  (ISO)
arteriosclerosis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Brain Death  (IEP)
brain edema  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchus carcinoma  (ISO)
bullous pemphigoid  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (IEP)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Bronchitis  (IEP)
Chronic Intermittent Hypoxia  (IEP)
chronic obstructive pulmonary disease  (ISO)
chronic ulcer of skin  (ISO)
colitis  (IEP)
Colonic Neoplasms  (ISO)
contact dermatitis  (ISO)
Crohn's disease  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (IDA,ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse large B-cell lymphoma  (ISO)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
Enteritis  (IEP)
Eosinophilic Myocarditis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
Experimental Colitis  (IEP,IMP)
Experimental Diabetes Mellitus  (IEP,ISO)
Fibrosis  (IEP)
gestational diabetes  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss, Noise-Induced  (IMP)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (IEP)
hyperhomocysteinemia  (IEP)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (IEP)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (IDA,IEP,ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (IEP)
Intimal Hyperplasia  (IMP)
iridocyclitis  (ISO)
Jaundice  (IEP)
Kidney Neoplasms  (ISO)
leukostasis  (ISO)
liver cirrhosis  (IEP,ISO)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP,IMP)
localized scleroderma  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (ISO)
Lymphocytic Myocarditis  (ISO)
malaria  (ISO,ISS)
melanoma  (ISO)
Mercury Poisoning  (IEP)
mesenteric vascular occlusion  (IMP)
metabolic dysfunction-associated steatohepatitis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (IEP,ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (IMP)
nephrosis  (ISO)
newborn respiratory distress syndrome  (IEP,ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (IEP,ISO)
paracoccidioidomycosis  (ISO)
Penetrating Wounds  (IEP)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
pneumonia  (IEP)
pre-eclampsia  (IMP)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (IMP)
Prinzmetal angina  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (IEP)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (IEP,IMP)
retinal disease  (ISO)
retinopathy of prematurity  (IEP)
rheumatic fever  (ISO)
rheumatic myocarditis  (ISO)
sciatic neuropathy  (IEP)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP)
Sjogren's syndrome  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (IMP)
stroke  (IMP,ISO)
Subarachnoid Hemorrhage  (IEP)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IEP)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (IDA,ISO)
venous insufficiency  (ISO)
Viral Myocarditis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-linalyl acetate  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,10-phenanthroline  (ISO)
1,8-cineole  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitroiodobenzene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
4-octylphenol  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
acrylamide  (EXP)
acteoside  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
Aeol 10150  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allicin  (ISO)
alloxan  (ISO)
alpha-naphthoflavone  (EXP)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
AM6545  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
anagliptin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
argatroban  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspalathin  (ISO)
astemizole  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atropine  (ISO)
Azoxymethane  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-eudesmol  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bongkrekic acid  (ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
Brusatol  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
candesartan  (EXP)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
capsazepine  (ISO)
capsiate  (ISO)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
Carboxyatractyloside  (ISO)
carnosine  (ISO)
Carnosol  (EXP,ISO)
carrageenan  (EXP)
CDP-choline  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
ceruletide  (ISO)
chenodeoxycholic acid  (ISO)
chloramine T  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloroquine  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
citral  (ISO)
citric acid  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
cloricromen  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclizine  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
dabrafenib  (ISO)
daunorubicin  (EXP)
DDE  (ISO)
Decursin  (ISO)
deguelin  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desflurane  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
digoxin  (ISO)
Dimaprit  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
donepezil hydrochloride  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
emodin  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ergosterol  (EXP)
Erionite  (ISO)
erythromycin A  (ISO)
estrone  (EXP)
etacrynic acid  (ISO)
ethanol  (ISO)
Ethyl icosapentate  (ISO)
etoricoxib  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
famotidine  (ISO)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
fasudil  (EXP)
fenamidone  (ISO)
fenbuconazole  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferrous oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
filipin III  (ISO)
flavokawain B  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
flurbiprofen  (EXP)
fluticasone  (ISO)
fluvoxamine  (EXP,ISO)
formaldehyde  (EXP,ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumaric acid  (ISO)
gadolinium trichloride  (ISO)
galangin  (ISO)
galanthamine  (EXP)
gallic acid  (EXP)
Garcinol  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geranial  (ISO)
geraniol  (EXP,ISO)
Ginkgolide C  (EXP)
ginsenoside C-K  (ISO)
glafenine  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidyl methacrylate  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
GW 3965  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (ISO)
halothane  (EXP,ISO)
helenalin  (ISO)
herbimycin  (ISO)
hesperetin  (EXP)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
Honokiol  (EXP)
hydralazine  (ISO)
hydrazines  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (EXP)
hydroxysafflor yellow A  (EXP,ISO)
hydroxytyrosol  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
icatibant  (EXP)
imidurea  (ISO)
imiquimod  (ISO)
imisopasem manganese  (EXP)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
Isoangustone A  (ISO)
isocarbophos  (EXP)
isoflurane  (EXP,ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketamine  (ISO)
ketorolac  (EXP)
ketotifen  (ISO)
Kukoamine B  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
leukotriene D4  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lopinavir  (ISO)
losartan  (EXP,ISO)
lucanthone  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
magnesium atom  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (EXP)
Methanandamide  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylene blue  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methylthiouracil  (ISO)
mevalonic acid  (ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP)
miquelianin  (ISO)
Mitoquinone  (ISO)
MitoTEMPO  (ISO)
Mizolastine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (EXP)
Morroniside  (ISO)
Muraglitazar  (EXP)
Mycotrienin I  (ISO)
Mycotrienin II  (ISO)
myricitrin  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-desethylamiodarone  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP)
Nandrolone decanoate  (EXP)
naringin  (ISO)
nebivolol  (ISO)
nectandrin B  (ISO)
nefazodone  (EXP)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
ochratoxin A  (EXP,ISO)
octanoic acid  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleuropein  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
pelargonidin  (ISO)
pentanal  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (EXP)
peptidoglycan  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (EXP)
phthalic anhydride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
piperazine  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
PR-39  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
Quinotrierixin  (ISO)
Quinupristin-dalfopristin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
sarpogrelate  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium chloride  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
Soman  (EXP,ISO)
stattic  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP,ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
tacrolimus hydrate  (EXP,ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (EXP,ISO)
telmisartan  (EXP,ISO)
tepoxalin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
Tetramethylthiourea  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thenoyltrifluoroacetone  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
tibolone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Torularhodin  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
Trienomycin A  (ISO)
trierixin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
xi-3-(4-Isopropylphenyl)-2-methylpropanal  (ISO)
Y-27632  (EXP,ISO)
zerumbone  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (IMP)
cell adhesion  (IBA,IEA,ISO)
cell adhesion mediated by integrin  (ISO)
cell-cell adhesion  (IDA,IEA,IMP)
cell-cell adhesion mediated by integrin  (ISO)
cellular response to alkaloid  (IEP)
cellular response to amyloid-beta  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucose stimulus  (IEA,IEP,ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IEP)
cellular response to nutrient levels  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
cellular senescence  (IEP)
establishment of endothelial barrier  (ISO)
establishment of endothelial intestinal barrier  (IMP)
establishment of Sertoli cell barrier  (IDA)
immune response  (IEA)
leukocyte adhesion to vascular endothelial cell  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration  (ISO,TAS)
membrane to membrane docking  (ISO)
negative regulation of calcium ion transport  (IDA)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (IMP)
ovarian follicle development  (IEP)
positive regulation of actin filament polymerization  (IDA)
positive regulation of cellular extravasation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of GTPase activity  (IDA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of vasoconstriction  (IMP)
regulation of activated T cell proliferation  (ISO)
regulation of cell shape  (IMP)
regulation of ruffle assembly  (ISO)
response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (IEP)
response to amino acid  (IEP)
response to amphetamine  (IEP)
response to copper ion  (IEP)
response to ethanol  (IEP)
response to gonadotropin  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to ionizing radiation  (IEP)
response to lipopolysaccharide  (IEP)
response to sulfur dioxide  (IEP)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
T cell antigen processing and presentation  (ISO)
T cell extravasation  (ISO)

Cellular Component

Molecular Function

References

References - curated
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34. Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. Farhood A, etal., J Leukoc Biol. 1995 Mar;57(3):368-74.
35. The transcription factor ETS-1 mediates proinflammatory responses and neointima formation in carotid artery endoluminal vascular injury. Feng W, etal., Hypertension. 2010 Jun;55(6):1381-8. Epub 2010 Apr 5.
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37. ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjogrens syndrome-like MRL/lpr mice. Gao J, etal., Exp Eye Res. 2004 Apr;78(4):823-35.
38. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
39. Anti-inflammatory Effect of Triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on Rat Model of Chronic Bronchitis. Ge JF, etal., Am J Chin Med. 2009;37(2):309-21.
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42. Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation. Haddad el-B, etal., J Immunol 2002 Jul 15;169(2):974-82.
43. Prediction of residual valvular lesions in rheumatic heart disease: role of adhesion molecules. Hafez M, etal., Pediatr Cardiol. 2013 Mar;34(3):583-90. doi: 10.1007/s00246-012-0501-7. Epub 2012 Sep 18.
44. Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats. Hamada Y, etal., J Neurochem. 1996 Apr;66(4):1525-31.
45. Concomitant upregulation of nuclear factor-kB activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat model. Hang CH, etal., Neurol India. 2005 Sep;53(3):312-7.
46. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. Hanrahan EO, etal., J Clin Oncol. 2010 Jan 10;28(2):193-201. Epub 2009 Nov 30.
47. Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. Hattori T, etal., Curr Eye Res. 2010 Feb;35(2):146-54. doi: 10.3109/02713680903447918.
48. Lower bone mineral density in children with type 1 diabetes is associated with poor glycemic control and higher serum ICAM-1 and urinary isoprostane levels. Heilman K, etal., J Bone Miner Metab. 2009;27(5):598-604. Epub 2009 Apr 17.
49. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Higano CS, etal., Cancer. 2009 Aug 15;115(16):3670-9.
50. In vivo evaluation of retinal injury after transient ischemia in hypertensive rats. Hirose F, etal., Hypertension. 2004 May;43(5):1098-102. Epub 2004 Mar 8.
51. Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule 1. Hobden JA, etal., Infect Immun. 1999 Feb;67(2):972-5.
52. Effects of monoclonal antibodies to adhesion molecules on eosinophilic myocarditis in Toxocara canis-infected CBA/J mice. Hokibara S, etal., Clin Exp Immunol. 1998 Nov;114(2):236-44.
53. Leukocyte adhesion and hepatic microvascular responses to intestinal ischemia/reperfusion in rats. Horie Y, etal., Gastroenterology. 1996 Sep;111(3):666-73.
54. Adhesion molecule expression in psoriatic skin lesions and the influence of cyclosporin A. Horrocks C, etal., Clin Exp Immunol. 1991 Apr;84(1):157-62.
55. Role of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 during nonsuppurative destructive cholangitis in a mouse graft-versus-host disease model. Howell CD, etal., Hepatology. 1999 Mar;29(3):766-76.
56. ICAM-1 polymorphisms and development of cutaneous malignant melanoma. Howell WM, etal., Int J Immunogenet. 2005 Dec;32(6):367-73.
57. Association of soluble intercellular adhesion molecule-1 with insulin resistance and metabolic syndrome in Taiwanese. Hsu LA, etal., Metabolism. 2009 Jul;58(7):983-8.
58. Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. Hu X, etal., J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):162-76. doi: 10.1177/1074248412465015. Epub 2012 Nov 8.
59. Dipyrithione attenuates oleic acid-induced acute lung injury. Huang H, etal., Pulm Pharmacol Ther. 2010 Oct 2.
60. Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. Huang YW, etal., Cancer Res. 1995 Feb 1;55(3):610-6.
61. Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. Ibrahim A, etal., Nutrition. 2012 Jul;28(7-8):799-802. doi: 10.1016/j.nut.2011.10.008. Epub 2012 Jan 20.
62. Increased levels of circulating intercellular adhesion molecule-1 in patients with localized scleroderma. Ihn H, etal., J Am Acad Dermatol. 1994 Oct;31(4):591-5.
63. Late persistent expressions of ICAM-1 and VCAM-1 on myocardial tissue in children with lymphocytic myocarditis. Ino T, etal., Cardiovasc Res. 1997 May;34(2):323-8.
64. S-nitroso-human-albumin: a new therapeutic approach in endotoxic shock. Jakubowski A Pol Arch Med Wewn. 2009 Jul-Aug;119(7-8):501-4.
65. Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-kappaB signaling pathway. Jiang Q, etal., Mol Cell Endocrinol. 2010 Jul 30.
66. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Jing H, etal., J Surg Res. 2012 Jul;176(1):63-73. doi: 10.1016/j.jss.2011.09.001. Epub 2011 Sep 29.
67. Glutathione depletion prevents lipopolysaccharide-induced local skin inflammation. Jones JJ, etal., Arch Surg. 1997 Nov;132(11):1165-9; discussion 1170.
68. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Joussen AM, etal., Am J Pathol 2002 Feb;160(2):501-9.
69. Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma. Jungraithmayr W, etal., Respirology. 2008 Nov;13(7):1022-7. Epub 2008 Aug 26.
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214. SO(2) inhalation modulates the expression of pro-inflammatory and pro-apoptotic genes in rat heart and lung. Yun Y, etal., J Hazard Mater. 2010 Sep 24.
215. Effects of intercellular adhesion molecule-1 on renal damage in spontaneously hypertensive rats. Zhang DW, etal., Ren Fail. 2012;34(7):915-20. doi: 10.3109/0886022X.2012.692751. Epub 2012 Jun 8.
216. Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats. Zhang HT, etal., Eur J Pharmacol. 2014 Oct 5;740:233-9. doi: 10.1016/j.ejphar.2014.07.033. Epub 2014 Jul 24.
217. [Effect of eye-acupuncture on cerebral intracellular adhesion molecule-1 expression in rats with acute cerebral ischemia-reperfusion injury]. Zhang LD, etal., Zhen Ci Yan Jiu. 2011 Dec;36(6):409-13.
218. Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Zhang RL, etal., Stroke. 1999 Mar;30(3):624-9.
219. Pentoxifylline inhibits intercellular adhesion molecule-1 (ICAM-1) and lung injury in experimental phosgene-exposure rats. Zhang XD, etal., Inhal Toxicol. 2010 Sep;22(11):889-95. doi: 10.3109/08958378.2010.493900.
220. Susceptibility to active decompensated cirrhosis is associated with polymorphisms of intercellular adhesion molecule-1 (ICAM-1) in chronic HBV carriers. Zhang XQ, etal., J Viral Hepat. 2008 Mar;15(3):173-8. doi: 10.1111/j.1365-2893.2007.00931.x.
221. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Zhang Y, etal., Int J Cardiol. 2010 Sep 17.
222. Effect of different concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats. Zhao S, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Sep;35(9):921-7.
223. Blockade of ICAM-1 improves the outcome of polymicrobial sepsis via modulating neutrophil migration and reversing immunosuppression. Zhao YJ, etal., Mediators Inflamm. 2014;2014:195290. doi: 10.1155/2014/195290. Epub 2014 May 6.
224. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
225. Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats. Zhou H, etal., Exp Biol Med (Maywood). 2010 Oct 1;235(10):1236-43. Epub 2010 Sep 1.
226. The protective effects of Lipoxin A(4) during the early phase of severe acute pancreatitis in rats. Zhou M, etal., Scand J Gastroenterol. 2010 Oct 18.
227. High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma. Zhu PP, etal., World J Gastroenterol. 2015 Jun 21;21(23):7254-63. doi: 10.3748/wjg.v21.i23.7254.
Additional References at PubMed
PMID:1448173   PMID:2477710   PMID:2479693   PMID:2538243   PMID:8562500   PMID:9290466   PMID:10528208   PMID:10601245   PMID:10903502   PMID:11078691   PMID:11880280   PMID:12061795  
PMID:12082081   PMID:12126535   PMID:12131776   PMID:12133872   PMID:12196270   PMID:12208882   PMID:12675845   PMID:12763482   PMID:12902516   PMID:14580850   PMID:14973438   PMID:15198126  
PMID:15201548   PMID:15215195   PMID:15240134   PMID:15249579   PMID:15489334   PMID:15598973   PMID:15624701   PMID:15742404   PMID:15754395   PMID:15860735   PMID:15946255   PMID:16199477  
PMID:16229173   PMID:16286275   PMID:16328103   PMID:16343550   PMID:16489637   PMID:16512644   PMID:16629649   PMID:16647725   PMID:16809613   PMID:16874877   PMID:16901988   PMID:16937496  
PMID:16973387   PMID:17033093   PMID:17336102   PMID:17344467   PMID:17369472   PMID:17590487   PMID:17670746   PMID:17690033   PMID:17991463   PMID:18326823   PMID:18379124   PMID:18400211  
PMID:18508964   PMID:18511851   PMID:18665080   PMID:18684012   PMID:18726687   PMID:18759008   PMID:18765197   PMID:18983774   PMID:19056867   PMID:19073885   PMID:19074435   PMID:19133316  
PMID:19241963   PMID:19581412   PMID:19666350   PMID:19697769   PMID:19726347   PMID:19856505   PMID:19946888   PMID:19997643   PMID:20079284   PMID:20150963   PMID:20197615   PMID:20335145  
PMID:20439489   PMID:20458337   PMID:20663304   PMID:20687137   PMID:20936719   PMID:20979835   PMID:21071702   PMID:21121367   PMID:21158154   PMID:21162227   PMID:21180061   PMID:21184129  
PMID:21194567   PMID:21276792   PMID:21423176   PMID:21448983   PMID:21464573   PMID:21472687   PMID:21683791   PMID:21724992   PMID:21764683   PMID:21860531   PMID:22333058   PMID:22351665  
PMID:22845610   PMID:23264465   PMID:23372835   PMID:23620790   PMID:23831969   PMID:23981064   PMID:24043249   PMID:24289084   PMID:24702024   PMID:25054130   PMID:25708190   PMID:25769821  
PMID:26351298   PMID:26419651   PMID:26531813   PMID:26838785   PMID:26853250   PMID:26923576   PMID:27072237   PMID:27525872   PMID:27559042   PMID:27782122   PMID:27889748   PMID:28089144  
PMID:28712960   PMID:30557594   PMID:30887556   PMID:31442237   PMID:32572407   PMID:34147590   PMID:35218622   PMID:35851539   PMID:37901475   PMID:37952156  


Genomics

Comparative Map Data
Icam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,829,688 - 27,841,618 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,829,161 - 27,841,617 (+)EnsemblGRCr8
mRatBN7.2819,553,063 - 19,565,438 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,553,645 - 19,565,438 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,573,091 - 23,584,847 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,870,936 - 21,882,706 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,783,338 - 19,795,094 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,035,287 - 22,047,049 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)Ensemblrn6Rnor6.0
Rnor_5.0822,092,155 - 22,103,917 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,040,177 - 20,051,939 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,948,090 - 20,959,852 (+)NCBICelera
RGSC_v3.1820,040,176 - 20,051,939 (+)NCBI
RH 3.4 Map8206.11RGD
Cytogenetic Map8q13NCBI
ICAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,271,120 - 10,286,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,271,093 - 10,286,615 (+)Ensemblhg38GRCh38
GRCh371910,381,796 - 10,397,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,242,779 - 10,258,291 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341910,242,778 - 10,258,291NCBI
Celera1910,276,917 - 10,292,687 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,965,426 - 9,977,270 (+)NCBIHuRef
CHM1_11910,381,783 - 10,397,556 (+)NCBICHM1_1
T2T-CHM13v2.01910,397,229 - 10,412,727 (+)NCBIT2T-CHM13v2.0
Icam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,927,236 - 20,940,110 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,927,281 - 20,940,113 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,015,940 - 21,028,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,015,985 - 21,028,817 (+)Ensemblmm10GRCm38
MGSCv37920,820,404 - 20,833,241 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,766,362 - 20,779,199 (+)NCBIMGSCv36mm8
Celera918,284,644 - 18,297,383 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.69NCBI
Icam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,561,714 - 1,574,755 (+)Ensembl
ChiLan1.0NW_0049554951,561,464 - 1,573,282 (+)NCBIChiLan1.0ChiLan1.0
ICAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,184,919 - 15,203,585 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,183,529 - 14,202,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,821,402 - 9,837,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,484,414 - 10,500,605 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,484,414 - 10,500,605 (+)EnsemblpanPan2panpan1.1
ICAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,818,715 - 50,827,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,818,715 - 50,827,914 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2050,688,470 - 50,697,454 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,340,345 - 51,349,327 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,340,352 - 51,349,346 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,546,484 - 50,555,463 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,975,237 - 50,984,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,216,377 - 51,225,401 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Icam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,727,534 - 209,738,599 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659616,752 - 627,174 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936659616,570 - 627,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ICAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,097,122 - 69,108,205 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1269,097,136 - 69,107,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,431,462 - 69,442,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ICAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,320,991 - 9,338,125 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,322,550 - 9,338,263 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607410,702,922 - 10,719,213 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Icam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,432,550 - 2,453,071 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,432,584 - 2,451,997 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Icam1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1817,279,224 - 17,290,965 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Icam1
79 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:95
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000028066
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH94539  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,565,254 - 19,565,417 (+)MAPPERmRatBN7.2
Rnor_6.0822,046,877 - 22,047,039NCBIRnor6.0
Rnor_5.0822,103,745 - 22,103,907UniSTSRnor5.0
RGSC_v3.4820,051,767 - 20,051,929UniSTSRGSC3.4
Celera820,959,680 - 20,959,842UniSTS
RH 3.4 Map8206.11UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000028066   ⟹   ENSRNOP00000028066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,829,161 - 27,841,617 (+)Ensembl
mRatBN7.2 Ensembl819,553,645 - 19,565,438 (+)Ensembl
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136567   ⟹   ENSRNOP00000108356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,829,821 - 27,841,617 (+)Ensembl
RefSeq Acc Id: NM_012967   ⟹   NP_037099
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,829,845 - 27,841,607 (+)NCBI
mRatBN7.2819,553,669 - 19,565,427 (+)NCBI
Rnor_6.0822,035,287 - 22,047,049 (+)NCBI
Rnor_5.0822,092,155 - 22,103,917 (+)NCBI
RGSC_v3.4820,040,177 - 20,051,939 (+)RGD
Celera820,948,090 - 20,959,852 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264947   ⟹   XP_063121017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,829,688 - 27,841,618 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037099 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121017 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81837 (Get FASTA)   NCBI Sequence Viewer  
  BAA00759 (Get FASTA)   NCBI Sequence Viewer  
  EDL78334 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028066
GenBank Protein Q00238 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037099   ⟸   NM_012967
- Peptide Label: precursor
- UniProtKB: Q00238 (UniProtKB/Swiss-Prot),   A6JNN2 (UniProtKB/TrEMBL),   A0A8L2QF25 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028066   ⟸   ENSRNOT00000028066
RefSeq Acc Id: XP_063121017   ⟸   XM_063264947
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QF25 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108356   ⟸   ENSRNOT00000136567
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00238-F1-model_v2 AlphaFold Q00238 1-545 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695772
Promoter ID:EPDNEW_R6296
Type:single initiation site
Name:Icam1_1
Description:intercellular adhesion molecule 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,035,267 - 22,035,327EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2857 AgrOrtholog
BioCyc Gene G2FUF-31444 BioCyc
Ensembl Genes ENSRNOG00000020679 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028066 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7122397 IMAGE-MGC_LOAD
InterPro ICAM UniProtKB/Swiss-Prot
  ICAM1_3_5_D2 UniProtKB/Swiss-Prot
  ICAM_N UniProtKB/Swiss-Prot
  ICAM_VCAM UniProtKB/Swiss-Prot
  ICAM_VCAM_N UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
KEGG Report rno:25464 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93596 IMAGE-MGC_LOAD
NCBI Gene 25464 ENTREZGENE
PANTHER INTERCELLULAR ADHESION MOLECULE UniProtKB/Swiss-Prot
  INTERCELLULAR ADHESION MOLECULE 1 UniProtKB/Swiss-Prot
Pfam ICAM1_3_5_D2 UniProtKB/Swiss-Prot
  ICAM_N UniProtKB/Swiss-Prot
  Ig_2 UniProtKB/Swiss-Prot
PhenoGen Icam1 PhenoGen
PRINTS ICAM UniProtKB/Swiss-Prot
  ICAMVCAM1 UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020679 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A8L2QF25 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M185_RAT UniProtKB/TrEMBL
  A6JNN2 ENTREZGENE, UniProtKB/TrEMBL
  ICAM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2000-05-25 Icam1  intercellular adhesion molecule 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs ebselen,a seleno-organic compound, prevents increase in mRNA levels in response to lipopolysaccharide (LPS)-induced lung injury 628391
gene_physical_interaction interaction with leukocyte receptors mediates adhesion and emigration of leukocytes 68698
gene_process regulates opioid-mediated analgesia and is important in intrinsic pain management in injured tissues 628391
gene_process endothelial protein mediating adhesion and extravasation of leukocytes 628354
gene_process decreased expression associated with tumorigenicity 729319
gene_regulation enhanced expression on vascular endothelium accompanied by immigration of opium containng immune cells in injured tissue 628391